Purpose: This study aims to identify the level of subjective noise perception among School Meal Facility Workers and analyze the relationship between subjective noise perception and insomnia, as well as the factors affecting insomnia. Methods: School meal facility workers were surveyed from November 1 to December 31, 2021, and 717 people were selected as participants for the study. Using SPSS/WIN 25.0, t-test, x 2 test, and multiple logistic regression analysis were conducted. The Korean Insomnia Severity Index (ISI-K) was used to evaluate insomnia. Results: The variables that showed significant differences in insomnia in general characteristics, health-related characteristics, subjective health perception, and subjective noise perception of the study participants were mental disorders such as subjective health perception, work stress, depression, etc., gastrointestinal disorders, and subjective noise perception, among which subjective health perception, mental disorders such as depression, and subjective noise perception were analyzed as factors influencing insomnia. Conclusion To improve the quality of insomnia and sleep among school meal facility workers, there is a need to improve healthcare, emotional management, and noisy work environments.

Purpose: This study aims to identify the level of subjective noise perception among School Meal Facility Workers and analyze the relationship between subjective noise perception and insomnia, as well as the factors affecting insomnia. Methods: School meal facility workers were surveyed from November 1 to December 31, 2021, and 717 people were selected as participants for the study. Using SPSS/WIN 25.0, t-test, x 2 test, and multiple logistic regression analysis were conducted. The Korean Insomnia Severity Index (ISI-K) was used to evaluate insomnia. Results: The variables that showed significant differences in insomnia in general characteristics, health-related characteristics, subjective health perception, and subjective noise perception of the study participants were mental disorders such as subjective health perception, work stress, depression, etc., gastrointestinal disorders, and subjective noise perception, among which subjective health perception, mental disorders such as depression, and subjective noise perception were analyzed as factors influencing insomnia. Conclusion To improve the quality of insomnia and sleep among school meal facility workers, there is a need to improve healthcare, emotional management, and noisy work environments.

Purpose: This study aims to identify the level of subjective noise perception among School Meal Facility Workers and analyze the relationship between subjective noise perception and insomnia, as well as the factors affecting insomnia. Methods: School meal facility workers were surveyed from November 1 to December 31, 2021, and 717 people were selected as participants for the study. Using SPSS/WIN 25.0, t-test, x 2 test, and multiple logistic regression analysis were conducted. The Korean Insomnia Severity Index (ISI-K) was used to evaluate insomnia. Results: The variables that showed significant differences in insomnia in general characteristics, health-related characteristics, subjective health perception, and subjective noise perception of the study participants were mental disorders such as subjective health perception, work stress, depression, etc., gastrointestinal disorders, and subjective noise perception, among which subjective health perception, mental disorders such as depression, and subjective noise perception were analyzed as factors influencing insomnia. Conclusion To improve the quality of insomnia and sleep among school meal facility workers, there is a need to improve healthcare, emotional management, and noisy work environments.

Purpose: This study aims to identify the level of subjective noise perception among School Meal Facility Workers and analyze the relationship between subjective noise perception and insomnia, as well as the factors affecting insomnia. Methods: School meal facility workers were surveyed from November 1 to December 31, 2021, and 717 people were selected as participants for the study. Using SPSS/WIN 25.0, t-test, x 2 test, and multiple logistic regression analysis were conducted. The Korean Insomnia Severity Index (ISI-K) was used to evaluate insomnia. Results: The variables that showed significant differences in insomnia in general characteristics, health-related characteristics, subjective health perception, and subjective noise perception of the study participants were mental disorders such as subjective health perception, work stress, depression, etc., gastrointestinal disorders, and subjective noise perception, among which subjective health perception, mental disorders such as depression, and subjective noise perception were analyzed as factors influencing insomnia. Conclusion To improve the quality of insomnia and sleep among school meal facility workers, there is a need to improve healthcare, emotional management, and noisy work environments.

Purpose: This study aims to identify the level of subjective noise perception among School Meal Facility Workers and analyze the relationship between subjective noise perception and insomnia, as well as the factors affecting insomnia. Methods: School meal facility workers were surveyed from November 1 to December 31, 2021, and 717 people were selected as participants for the study. Using SPSS/WIN 25.0, t-test, x 2 test, and multiple logistic regression analysis were conducted. The Korean Insomnia Severity Index (ISI-K) was used to evaluate insomnia. Results: The variables that showed significant differences in insomnia in general characteristics, health-related characteristics, subjective health perception, and subjective noise perception of the study participants were mental disorders such as subjective health perception, work stress, depression, etc., gastrointestinal disorders, and subjective noise perception, among which subjective health perception, mental disorders such as depression, and subjective noise perception were analyzed as factors influencing insomnia. Conclusion To improve the quality of insomnia and sleep among school meal facility workers, there is a need to improve healthcare, emotional management, and noisy work environments.

This study aimed to investigate the effects of vitamin and antioxidant supplements in the prevention of bladder cancer using a meta-analysis of randomized controlled trials (RCTs). Fourteen RCTs were included in the final analysis. In a fixed-effect meta-analysis, vitamin and antioxidant supplements showed no preventive effect for bladder cancer (relative risk [RR] = 1.04; 95% confidence interval [CI] 0.92–1.17; I² = 39.7%). Also, there was no preventive effect of these supplements in the subgroup meta-analyses by various factors such as type of supplements, type of cancer prevention, methodological quality, providers of supplements, type of control group, and number of participants. Among the subgroup analyses by type of supplements, beta-carotene supplementation alone marginally increased the risk of bladder cancer (RR = 1.44; 95% CI 1.00–2.09; I² = 0.0%; n = 3). The current meta-analysis found that vitamin and antioxidant supplements have no preventive effect against bladder cancer.

The importance of anaplastic lymphoma kinase (ALK) as an oncogene in non-small cell lung cancer (NSCLC) has emerged as a major concern due to a dramatic clinical effect of targeted therapy. As compared with the research for targeted therapy, the study about clinicopathological characteristics for ALK positive NSCLC hasn't been worked enough. Here, we describe a 35-year-old woman diagnosed with stage IVb NSCLC with ALK rearrangement. During evaluating her disease, a metastatic lesion to uterine cervix was found. Although lung cancer metastasis to female genital tract is rare, we also present case series that show a metastasis to the female genital tract in NSCLC with ALK rearrangement. These case series could suggest that ALK positive NSCLC has distinct metastatic pattern.
Adenocarcinoma* ; Adult ; Carcinoma, Non-Small-Cell Lung ; Cervix Uteri* ; Female ; Glycogen Storage Disease Type VI ; Humans ; Lung Neoplasms ; Lung* ; Lymphoma* ; Neoplasm Metastasis* ; Oncogenes ; Phosphotransferases*

Duodenal diverticulitis is a rare complication of the duodenal diverticulum. Its rarity is due to the relatively large diameter of the duodenum, which makes the intraluminal flow of sterile liquid duodenal contents fluent. Additionally, nonspecific signs and symptoms of duodenal diverticulitis make it very difficult to diagnose properly. We describe a patient presenting with abdominal pain, nausea, and leukocytosis, with diverticulitis of the third portion of the duodenum caused by the impaction of a foreign body, who was diagnosed and treated with enteroscopy.
Abdominal Pain ; Diverticulitis ; Diverticulum ; Double-Balloon Enteroscopy ; Duodenum ; Foreign Bodies ; Humans ; Leukocytosis ; Nausea

BACKGROUND/AIMS: Proton pump inhibitor-responsive esophageal eosinophilia (PPI-REE) is a newly recognized form of eosinophilic esophagitis (EoE) that responds to PPI therapy. It remains unclear whether PPI-REE represents a subphenotype of gastroesophageal reflux disease, a subphenotype of EoE, or its own distinct entity. The aim was to evaluate the clinicopathologic features of PPI-REE. METHODS: Six patients were diagnosed with PPI-REE based on symptoms, endoscopic abnormalities, esophageal eosinophilia with > or =15 eosinophils/high-power field, and a response to PPI treatment. Symptoms and endoscopic and pathological findings were evaluated. RESULTS: The median follow-up duration was 12 months. Presenting symptoms included dysphagia, heartburn, chest pain, foreign body sensation, acid reflux, and sore throat. All patients had typical endoscopic findings of EoE such as esophageal rings, linear furrows, nodularity, and whitish plaques. Three patients had a concomitant allergic disorder, and one had reflux esophagitis. Four patients exhibited elevated serum IgE, and five had positive skin prick tests. All patients experienced symptomatic resolution within 4 weeks and histologic resolution within 8 weeks after starting PPI therapy. There was no symptomatic recurrence. CONCLUSIONS: PPI therapy induced rapid resolution of symptoms and eosinophil counts in patients with PPI-REE. Large-scale studies with long-term follow-up are warranted.
Adult ; Asian Continental Ancestry Group ; Chest Pain/etiology ; Deglutition Disorders/etiology ; Diagnosis, Differential ; Eosinophilic Esophagitis/complications/*drug therapy/*pathology ; Esophagus/pathology ; Female ; Follow-Up Studies ; Gastroesophageal Reflux/etiology ; Heartburn/etiology ; Humans ; Male ; Middle Aged ; Pharyngitis/etiology ; Phenotype ; Proton Pump Inhibitors/*therapeutic use ; Republic of Korea ; Retrospective Studies ; Sensation Disorders/etiology ; Treatment Outcome ; Young Adult

Background: There have been some domestic and overseas cases of anti-D alloimmunization caused by the transfusion of serologically D-negative blood. However, it is difficult to distinguish between true D-negative and DEL variants using conventional serologic typing. Therefore, we established the RHD genotyping algorithm for the detection of DEL variants and applied this algorithm to serologic D negative donors who voluntarily consented to testing. Methods: From September 2016 to December 2020, 216 RHD negative donors who were C＋ and/or E+ in previous serologic typing were recruited. The screening test was PCR amplification of the RHD exons 4, 7, 10, and a promotor. Based on the results of PCR screening, true D-negative samples and RHD variants (including DEL) were discriminated. When the result was a RHD variant, exon 9 was sequenced to identify the nucleotide changes. Full sequencing was performed if no mutations were detected at exon 9. Results: Among the 216 participants, 39 cases with the C−E−c＋e＋ phenotypes that did not meet the recruitment criteria were excluded from data analysis. Among the remaining 177 samples, 68 cases (38.4%) were RHD total deletions, 35 cases (19.8%) were RHD-CE-D hybrids, and 74 cases (41.8%) were RHD variants. Among the cases of RHD variants, 73 cases (98.6%) had c.1227G＞A substitutions and were confirmed as Asian-type DEL. Conclusion Seventy-four cases of serologic D negative donors were reclassified as RHD variants by RHD genotyping. This is believed to have contributed to the improvement of transfusion safety by lowering the risk of anti-D alloimmunization in D-negative patients.