The value of prophylactic cranial irradiation (PCI) for small cell lung cancer (SCLC) remains controversial. From Nov.1987 to Jan. 1993, thirty-one patients with small cell lung cancer received PCI. PCI was given for complete remission SCLC patients after chemotherapy and chest radiotherapy. The total dose of PCI was 40Gy in 26 cases, 30～

Objective To investigate the infection of Xuebijing injection on inflammatory factor of large sized avulsion patients.Methods 70 patients being selected with large sized avulsion were randomly recruited into a treatment group(35 patients)and a control group(35 patients).The control group received traditional comprehensive treatment.On this basis,Xucbijing injection was injected to the treatment group on admission day,and Xuebijing injection 50 ml in 0.9%NaCl solution 100 ml was,intravenously infused for 60 min once,2 times daily,up to 7 d.TNF-α,IL-6,CRP,WBC and NEU%of the two groups were respectively detected before treatment and 7 days after the treatment.Exudation of wound surface was also observed.Results After 7 days of treatment,there was significant difierence in the treatment group compared with pretreatment(P＜0.01).There was statistical difference between two groups after 7 days of treatment(P＜0.01).Exudation of wound surface of the treatment group was less than the control group's.Conclusion Xuebijing injection has antagonistic effect on inflammatory factor of large sized avulsion patients and can lessen exudation of wound surface.

Objective To investigate the relationship between hypoxia inducible factor-1?、angiopoietin2 and vascular endothelial growth factor and angiogenesis in hepatocellular carcinoma(HCC).Methods The(expression) of hypoxia inducible factor-1?、angiopoietin2 and vascular endothelial growth factor mRNA was(detected) in 52 HCC surgical specimens.And microvessel density(MVD) in tissue specimens of patients with coexpression of the parameters was examined.Results Of the 52 surgical specimens,36 cases had over(expression) of HIF-?、angiopoietin and VEGF protein,and coexpression of HIF-? and angiopoietin and VEGF mRNA in 38 of 52 cases.The expression of HIF-?、angiopoietin was related with the expression of VEGF(r_1= 0.783,P

Objective To investigate the diagnosis and treatment of malignant fibrous histiocytoma (MFH) in abdominal cavity. Methods The clinical manifestations, imaging examination, pathology, methodology, effect of treatment and prognosis of 28 MFH patients were retrospectively analyzed. Results Tumors were in the retroperitoneal space in 17 cases, within abdominal cavity in 6, in mesentery in 3 cases, and in the abdominal wall in 2 cases. The clinical symptoms were body weight loss, abdominal pain and mass. B ultrasonography and CT scanning showed mass in the abdomen. 24 cases were with multiplefoci,4 cases were with a single mass. Seventeen cases underwent complete tumor resection,11 cases with partial resection, 16 cases received postoperative chemotherapy and 14 cases with postoperative radiotherapy. The overall survival rate of 1-, 3- and 5- year was 76.9%,26.9% and 3.9%,respectively. Conclusion MFH is most often located in retroperitoneal space, surgical resection was the treatment of choice. The prognosis in patients with MFH might be improved by complete resection combined with chemotherapy or/ and radiotherapy.

BACKGROUND:Moxibustion products produced in moxibustion, such as moxa smoke, are one of hotspots in moxibustion research. Metabonomics can be used to more comprehensively and systematicaly study the effects of moxibustion products on the body.
OBJECTIVE:To investigate the efect of diferent concentrations of moxibustion products on urine metabonomics of rats.
METHODS:Forty Sprague-Dawley rats were randomly divided into normal control group, low-dose moxibustion products group, middle-dose moxibustion products group, high-dose moxibustion products group, high-dose moxibustion products recovery group. In the latter four groups, rats from each group were exposed to the mixture of moxibustion products and pure gas at ratios of 0.4:2.0, 0.8:2.0, 1.6:2.0, 1.6:2.0, respectively, 4 hours daily, 5 days weekly, totaly for 60 days. After 60-day high-dose moxibustion products stimulation, rats in the high-dose moxibustion products recovery group were raised in normal air for 21 days. Rats in the normal control group were raised in normal air for 60 days without any moxibustion products. Then we analyzed the changes of urine metabonomics in al group rats.
RESULTS AND CONCLUSION: Totaly 108 metabolites were identified in the urine of rats using gas chromatography/time-of-flight mass spectrometry, and 64 metabolites were verified by standard library. There were some positive correlations between changes of typical metabolites and moxibustion product concentrations. The metabolites in the urine were most different between the high-dose moxibustion products group and normal control group. Twenty-two differential metabolites, such as glucuronic acid and vitamin C were mainly involved in 15 sugar and amino acid metabolic pathways, such as ascorbate and aldarate metabolism. These findings indicated that energy metabolism, detoxification and anoxidation increased in rats stimulated by moxibustion products.

Objective　To investigate the therapeutic effect and safety of PBSCT combined with high dose chemotherapy in the treatment of small cell lung cancer(SCLC). Methods　From March, 1994 to June, 1999, high dose chemotherapy combined with PBSCT was carried out in 20 patients with SCLC. Eight patients were in CR status while twelve patients were for salvaging therapy. Allo-PBSCT was performed in 1 patient and Auto-PBSCT in 19 patients. After mobilization of stem cell, mononeuclear cell (MNC) was collected for ≥3.0×108／kg, CD34＋ cell≥2.0×106／kg. The high dose chemotherapy included carboplatin 350?mg／m2×3 days, VP-16 120?mg／m2×5 days, and E-ADM 40?mg／m2×2 days. Results　Encouraging results were achieved in 8 patients who were in CR status. Seven of the eight patients survived after Auto-PBSCT. One patients survived more than 1 year, 4 cases over 2 years, and 3 cases over 3 years. Of the 3 patients, 2 survived more than 4 years. In the group of salvaging therapy, response was good, however there was no long-term survival and median remission time was only 3.5 months. Conclusion　High dose chemotherapy combined with PBSCT in the treatment of SCLC with CR status is feasible and safe, although the side effects are severe too. It is worth further studying on clinical practice.

Objective: To observe the effect of moxibustion on the colonic mucosal barrier of rats with ulcerative colitis (UC) induced by dextran sulfate sodium (DSS). Methods: Forty male Sprague-Dawley rats were randomly divided into a normal group and a modeling group, with 20 rats in each group. Rats in the modeling group were subjected to preparing experimental UC models by drinking 4％ DSS for seven consecutive days. Two modeled rats and two normal rats were randomly selected for model identification. After the success of UC model was confirmed, the remaining 18 modeled rats were randomly divided into three groups, a model group, a model + herbal cake-partitioned moxibustion group, and a model + mild moxibustion group, with six rats in each group; the remaining normal rats were randomly divided into three groups, a normal group, a normal + herbal cake-partitioned moxibustion group, and a normal + mild moxibustion group, with six rats in each group. After 7 d of intervention with the herbal cake-partitioned moxibustion or the mild moxibustion, hematoxylin-eosin (HE) staining technique was used to observe the pathological changes of colon tissue under a light microscope; Western blotting and/or immunohistochemical techniques were used to detect the protein expression levels of Occludin, Claudin, junction adhesion molecular 1 (JAM1), mucin 2 (MUC2), and transforming growth factor beta1 (TGF-β1) in rat colon tissue. Results: Compared with the normal group, the colon tissue was severely damaged, the pathological score was significantly increased, and the protein expression levels of Occludin, Claudin, JAM1, MUC2, and TGF-β1 were significantly decreased in the model group (P<0.01); while there were no significant differences in the colonic histopathological score, protein expression levels of Occludin, Claudin, JAM1, MUC2, and TGF-β1 in the normal + herbal cake-partitioned moxibustion group and the normal + mild moxibustion group (P>0.05). Compared with the model group, the model + herbal cake-partitioned moxibustion group and the model + mild moxibustion group showed repaired colon tissue, ulcer healing, significantly reduced pathological score, and significantly increased protein expression levels of JAM1, MUC2, and TGF-β1 (P<0.05); the Occludin protein expression level in the colon tissue of the model + mild moxibustion group was increased (P<0.01). Conclusion: Neither herbal cake-partitioned moxibustion nor mild moxibustion influences the colonic histopathology and intestinal mucosal barrier-related protein expression in the normal rats; both herbal cake-partitioned moxibustion and mild moxibustion can up-regulate the protein expression levels of JAM1, MUC2, and TGF-β1 in the colon tissue of UC rats. Mild moxibustion can up-regulate Occludin protein expression. This may be a mechanism of moxibustion in reducing colonic mucosa inflammation in UC.

Objective:To investigate the two-dimensional ultrasound ,color Doppler ultrasound and ultrasonic elastography fea-tures of breast phylloides tumors .Methods :Sixteen cases of breast phylloides tumors proved by pathology were retrospectively analyzed .Results:In all cases ,there was a single tumor .Postoperative pathological results proved benign ,borderline and ma-lignant breast phylloides tumor in 8 ,4 and 4 cases ,respectively ;and the mean diameters of them were 30 mm ,41 mm and 38 mm ,respectively .Twelve lesions were lobulated and 4 oval in 16 tumers .The tumor margins were circumscribed in all cases , and 2 malignant lesions had incomplete capsules .Intramural clefts and high echo separations were found in 12 lesions .All le-sions had posterior enhancement .Grade II-III blood flow were seen in 7 benign lesions ,3 borderline lesions and 4 malignant le-sions .In ultrasontic elastography fifteen lesions had horizontal red/yellow stripes ,8 lesions had more than ten red/yellow stripes ,2 borderline lesions and 2 malignant lesions had a mosaic pattern of red and green in the centre and blue “ring sign”in the periphery .There were 7 ,3 ,2 lesions scored as 1 ,and 1 ,1 ,2 lesions scored as 3 on ultrasonic elastography for benign , borderline and malignant phylloides tumors ,respectively .Conclusions:The breast phylloides tumors mostly present as lobulated , well circumscribed ,intramural cleft ,high echo separations ,posterior enhancement and abundant blood flow on ultrasound . Many horizontal red/yellow stripes are typical appearance of breast phylloides tumors on elastography .Incomplete capsule , scored as 3 on elastography or blue“ring sign” in the periphery suggest borderline and malignancy phylloides tumors .

Objective :To investigate ultrasonographic features of neuroendocrine carcinoma of breast . Methods :The ultrasonographic features of twenty-nine patients with neuroendocrine carcinoma of breast confirmed by pathology were retrospectively analyzed .Among them ,twenty-five cases were invasive neuroendocrine carcinomas while the other four cases were neuroendocrine carcinomas in situ .Results :Twenty-six lesions were hypoechoic while the other three were isoechoic . Twenty-three lesions were heterogeneous while the other 6 were homogeneous .The shape was irregular in twenty-three masses and regular in 6 masses . Microcalcification was found in 11 masses while hyperechoic halo was found in 1 mass . Hypervascular ,isovascular ,hypovascular and avascular images were found in 15 ,9 ,3 ,and 2 masses ,respectively .Eight masses were examined by ultrasound elastography .According to elastography score ,1 ,3 ,and 4 points were found in 1 ,2 , and 5 masses , respectively . The accuracy rate of ultrasonographic diagnosis for breast mass was 97% (28/29 ) . And the accuracy rate of ultrasonographic diagnosis for ipsilateral axillary lymph node metastases was 75% (9/12 ) .Conclusions :Features such as heterogeneous echo ,irregular shape ,microcalcification inside mass ,hypervascular image and high score on elastography are frequent for neuroendocrine carcinoma of breast .The combined application of gray-scale ultrasound ,color Doppler ultrasound and ultrasound elastography may be conducive to the differential diagnosis of lesion .

Objective :To investigate the imaging features of metaplastic breast carcinoma by grayscale ultrasound , color Doppler ultrasound and ultrasound elastography .Methods :Imaging data of metaplastic breast carcinoma of twenty cases proved by pathology were retrospectively analyzed .Results :There were eighteen masses with hypoecho and 2 masses with medium echo .Ten masses showed heterogeneous echo and the other ten showed homogeneous echo .The shape was irregular in 13 masses ,oval in 4 masses and microlobulated in 3 masses .The margin was circumscribed in 15 masses and indistinct in 5 masses .Microcalcifications were found in 6 masses .Echo free space was found in 9 masses .There were 18 cases with posterior acoustic enhancement , one case with invariable posterior echo and one case with posterior attenuation . Hypervascular , isovascular ,and avascular masses were found in 14 ,4 ,and 2 cases ,respectively .The mean resistance index was 0 .77 .Four masses were examined by ultrasound elastography .One mass was scored as 3 and 3 masses were scored as 4 .The accuracy rate of ultrasonic diagnosis for breast mass was 85% (17/20) .And the accuracy rate of ultrasonic diagnosis for ipsilateral axillary lymph nodes was 75% (3/4) .Conclusions :Irregular shape ,posterior acoustic enhancement ,cystic spaces ,microcalcifications , hypervascular mass and high elastography score are the most frequent ultrasonic features for metaplastic breast carcinoma .The combination application of grayscale ultrasound ,color Doppler ultrasound and ultrasound elastography may be conducive to the etiologic diagnosis of lesion .