1.Study on the immunogenicity of adeno-vector vaccine against H5N1 influenza A virus
Xiaoguang ZHANG ; KUIbiao LI ; Jing MA ; Naifu WANG ; Xiaomei ZHANG ; Yunhu SANG ; Fie DONG ; Hong XU ; Yi ZENG
Chinese Journal of Experimental and Clinical Virology 2009;23(2):97-99
Objective To construct adenovirus vector vaccine against H5N1 influenza virus and study on the immunogeuicity. Methods In this study, we amplified hemagglutinin (HA) gene sequence of H5N1 influenza virus (A/Anhui/1/2005), then constructed an adenovirus vector vaccine (Adv-HA), followed by tests in BALB/c mice for the immunogenicity with the vaccine and immunization strategies. Results The recombinate Adv-HA vaccine could effectively induce both humoral and cellular immunity against human H5N1 influenza virus. Conclusion The Adv-HA vaccination against H5N1 influenza is a potential strategy and worthy of further investigation.
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