PURPOSE: To examine the effect of the exercise.behavior modification therapy one the obesity control and self-esteem of the obese female college students. METHOD: Data was collected from March 10, 2006 to June 10, 2006. The research design was adopted randomized control group (EG=exercise group) pretest-posttest experimental (E . BG=exercise . behavior modification therapy group) design. The subjects were nursing students at T college. A total of 37 obese female college students(BMI: over 27mg/m2) were selected for this research. The exercise program was executed for 12 weeks and 4 days a week, and the behavior modification was therapy performed for 12 weeks and 60 minutes per week. The data were analyzed with the SPSS Win 12.0 program through the Mann-Whitney test. RESULT: BMI(Z=-3.049, p=.002) of the E . BG was significantly different from the EG. The Total Cholesterol(Z=-1.162, p=.250) of the E . BG was not significantly different from the EG. The self-esteem(Z=-3.196, p=.001) of the E.BG was significantly different from the EG. CONCLUSION: The exercise . behavior modification therapy was more effective than the exercise therapy in improving the obesity and self-esteem of the obese female college students.
Behavior Therapy ; Exercise Therapy ; Female ; Humans ; Obesity* ; Research Design ; Self Concept ; Students, Nursing

PURPOSE: This study attempted to identify differences in elders' health status, quality of life, and satisfaction with customized home visiting health service depending on connection to volunteerism. METHODS: A total of 400 subjects participated in this research. Data were collected from May to August of 2009 and the measurement tool used for this study was the house visiting health service recording sheet recommended by the Ministry of Health. RESULTS: According to the results of this research on elders' health status in customized home visiting health service depending on connection to volunteerism, elders connected to volunteerism positively showed a high level in functional health status areas such as daily life performance ability, instrumental daily life performance ability and Joint exercise capacity, and in the quality of life area. CONCLUSION: The results of this study can be utilized as complementary information when resources and networks are used for the effective management of house visiting health service subjects.
Health Services* ; House Calls* ; Joints ; Quality of Life* ; Volunteers*

PURPOSE: This study was performed to examine parenting attitude and stress according to personality type in elementary school students' mothers. METHODS: The subjects consisted of 206 mothers of students. The measurement instrument was the questionnaire consisting of Korean-version MBTI and PSI test. Data was collected from March 15th to April 15th, 2008. RESULTS: Among personality types by function, ST type was most, occupying 60.2%. Among personality types by temperament, SJ type was most, occupying 59.2%. The score of affective attitude was highest among the parenting attitudes. Parenting attitude was significantly different according to age, education, economic status, number of children, planned pregnancy, factor of stress, and family type. Parenting stress was significantly different according to planned pregnancy and factor of stress. In parenting attitudes by personality types, affective attitude was significantly different. Parenting stress was significantly different according to personality type by function. There was a negative correlation between affective and autonomic attitudes and parenting stress. There was a positive correlation between rejective attitude and parenting stress. CONCLUSION: It would be essential to provide dynamic developmental programs for increasing the children's social ability, and nursing intervention, education and counseling programs for decreasing parenting stress through understanding mothers' personality type.
Child ; Counseling ; Education ; Family Planning Services ; Humans ; Mothers* ; Nursing ; Parenting* ; Parents* ; Temperament ; Surveys and Questionnaires

PURPOSE: The study was conducted in order to identify factors influencing depression and quality of life in elderly customized home visiting health services. METHODS: A total of 442 people participated as the subjects of this study. Data were collected during the period from June to September in 2010 and the measurement tool used for this study was the customized home visiting health service recording sheet recommended by the Ministry of Health. Data were analyzed using t-test, one-way ANOVA, Pearson correlation coefficients, and stepwise multiple regression with SPSS/WIN 17.0. RESULTS: Depression was correlated negatively with quality of life. According to the results of this research, factors influencing depression in elderly customized home visiting health services were quality of life, customized home visiting health service period, and IADL. Factors influencing quality of life in elderly customized home visiting health services were depression, joint exercise capacity, age, connection to volunteerism, IADL and ADL. CONCLUSION: The results of this study can be leveraged as complementary information for the effective management of customized home visiting health service subjects. Moreover, the results can be used as a reference for future studies.
Activities of Daily Living ; Aged* ; Depression* ; Health Services* ; House Calls* ; Humans ; Joints ; Quality of Life* ; Volunteers

Aucubin is a small compound naturally found in traditional medicinal herbs with primarily anti-inflammatory and protective effects. In the nervous system, aucubin is reported to be neuroprotective by enhancing neuronal survival and inhibiting apoptotic cell death in cultures and disease models. Our previous data, however, suggest that aucubin facilitates neurite elongation in cultured hippocampal neurons and axonal regrowth in regenerating sciatic nerves. Here, we investigated whether aucubin facilitates the differentiation of neural precursor cells (NPCs) into specific types of neurons. In NPCs cultured primarily from the rat embryonic hippocampus, aucubin significantly elevated the number of GAD65/67 immunoreactive cells and the expression of GAD65/67 proteins was upregulated dramatically by more than three-fold at relatively low concentrations of aucubin (0.01 µM to 10 µM). The expression of both NeuN and vGluT1 of NPCs, the markers for neurons and glutamatergic cells, respectively, and the number of vGluT1 immunoreactive cells also increased with higher concentrations of aucubin (1 µM and 10 µM), but the ratio of the increases was largely lower than GAD expression and GAD immunoreactive cells. The GABAergic differentiation of pax6-expressing late NPCs into GABA-producing cells was further supported in cortical NPCs primarily cultured from transgenic mouse brains, which express recombinant GFP under the control of pax6 promoter. The results suggest that aucubin can be developed as a therapeutic candidate for neurodegenerative disorders caused by the loss of inhibitory GABAergic neurons.
Animals ; Axons ; Brain ; Cell Death ; GABAergic Neurons* ; Hippocampus ; Mice ; Mice, Transgenic ; Nervous System ; Neurites ; Neurodegenerative Diseases ; Neurons ; Plants, Medicinal ; Rats ; Sciatic Nerve

Aucubin is an iridoid glycoside with a wide range of biological activities, including anti-inflammatory, anti-microbial, anti-algesic as well as anti-tumor activities. Recently, it has been shown that aucubin prevents neuronal death in the hippocampal CA1 region in rats with diabetic encephalopathy. In addition, it has protective effects on H2O2-induced apoptosis in PC12 cells. We have shown here that aucubin promotes neuronal differentiation and neurite outgrowth in neural stem cells cultured primarily from the rat embryonic hippocampus. We also investigated whether aucubin facilitates axonal elongation in the injured peripheral nervous system. Aucubin promoted lengthening and thickness of axons and re-myelination at 3 weeks after sciatic nerve injury. These results indicate that administration of aucubin improved nerve regeneration in the rat model of sciatic nerve injury, suggesting that aucubin may be a useful therapeutic compound for the human peripheral nervous system after various nerve injuries.
Animals ; Apoptosis ; Axons* ; CA1 Region, Hippocampal ; Hippocampus ; Humans ; Models, Animal ; Nerve Regeneration ; Neural Stem Cells* ; Neurites* ; Neurons ; PC12 Cells ; Peripheral Nervous System ; Rats ; Regeneration* ; Sciatic Nerve*

The 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP), a protein of unknown function in vivo, is abundantly expressed in myelinating glia in two isoforms, CNP1 and CNP2. In this study, immunoblot analysis showed that CNP1 is the major isoform in adult forebrain, and that both isoforms are included in the postsynaptic density (PSD) fraction and tyrosine-phosphorylated at the basal level. However, subcellular distribution and detergent extraction data showed that CNP is nonspecifically associated with the PSD fraction. Immunocytochemistry revealed that CNP is detected, in a weak but punctate pattern, in dissociated rat hippocampal neurons of 3 days to 2 weeks in vitro. The CNP-positive punctae were distributed throughout soma and dendrites, and distinct from PSD95-positive ones. Immunoblot analysis indicated that CNP is also expressed in neuronal stem cell lines, HiB5 and F11. Interestingly, in addition to the known two isoforms, a new CNP isoform of MW 45 kDa was expressed in these cell lines and was the major type of isoform in F11 cells. Taken together, our data suggest that CNP is expressed in the early stage of in vitro development and nonspecifically included in the adult rat PSD fraction.
2',3'-Cyclic-Nucleotide Phosphodiesterases/*metabolism ; Aging/physiology ; Animals ; Cells, Cultured ; Hippocampus/cytology/metabolism ; Immunohistochemistry ; Nerve Tissue Proteins/*metabolism ; Neurons/metabolism ; Phosphotyrosine/metabolism ; Prosencephalon/cytology/*metabolism ; Rats ; Rats, Sprague-Dawley ; Substrate Specificity

PURPOSE: We analyzed a series of patients who had undergone laparoscopic partial nephrectomies (LPNs) and open partial nephrectomies (OPNs) to compare outcomes of the two procedures in patients with pathologic T1a renal cell carcinomas (RCCs). MATERIALS AND METHODS: From January 1998 to May 2009, 417 LPNs and 345 OPNs were performed on patients with small renal tumors in 15 institutions in Korea. Of the patients, 273 and 279 patients, respectively, were confirmed to have pT1a RCC. The cohorts were compared with respect to demographics, peri-operative data, and oncologic and functional outcomes. RESULTS: The demographic data were similar between the groups. Although the tumor location was more exophytic (51% vs. 44%, p=0.047) and smaller (2.1 cm vs. 2.3 cm, p=0.026) in the LPN cohort, the OPN cohort demonstrated shorter ischemia times (23.4 min vs. 33.3 min, p<0.001). The LPN cohort was associated with less blood loss than the OPN cohort (293 ml vs. 418 ml, p<0.001). Of note, two patients who underwent LPNs had open conversions and nephrectomies were performed because of intra-operative hemorrhage. The decline in the glomerular filtration rate at the last available follow-up (LPN, 10.9%; and OPN, 10.6%) was similar in both groups (p=0.8). Kaplan-Meier estimates of 5-year local recurrence-free survival (RFS) were 96% after LPN and 94% after OPN (p=0.8). CONCLUSIONS: The LPN group demonstrated similar rates of recurrence-free survival, complications, and postoperative GFR change compared with OPN group. The LPN may be an acceptable surgical option in patients with small RCC in Korea.
Carcinoma, Renal Cell* ; Cohort Studies ; Demography ; Follow-Up Studies ; Glomerular Filtration Rate ; Hemorrhage ; Humans ; Ischemia ; Kidney Neoplasms ; Korea ; Nephrectomy* ; Outcome Assessment (Health Care)

PURPOSE: We analyzed a series of patients who had undergone laparoscopic partial nephrectomies (LPNs) and open partial nephrectomies (OPNs) to compare outcomes of the two procedures in patients with pathologic T1a renal cell carcinomas (RCCs). MATERIALS AND METHODS: From January 1998 to May 2009, 417 LPNs and 345 OPNs were performed on patients with small renal tumors in 15 institutions in Korea. Of the patients, 273 and 279 patients, respectively, were confirmed to have pT1a RCC. The cohorts were compared with respect to demographics, peri-operative data, and oncologic and functional outcomes. RESULTS: The demographic data were similar between the groups. Although the tumor location was more exophytic (51% vs. 44%, p=0.047) and smaller (2.1 cm vs. 2.3 cm, p=0.026) in the LPN cohort, the OPN cohort demonstrated shorter ischemia times (23.4 min vs. 33.3 min, p<0.001). The LPN cohort was associated with less blood loss than the OPN cohort (293 ml vs. 418 ml, p<0.001). Of note, two patients who underwent LPNs had open conversions and nephrectomies were performed because of intra-operative hemorrhage. The decline in the glomerular filtration rate at the last available follow-up (LPN, 10.9%; and OPN, 10.6%) was similar in both groups (p=0.8). Kaplan-Meier estimates of 5-year local recurrence-free survival (RFS) were 96% after LPN and 94% after OPN (p=0.8). CONCLUSIONS: The LPN group demonstrated similar rates of recurrence-free survival, complications, and postoperative GFR change compared with OPN group. The LPN may be an acceptable surgical option in patients with small RCC in Korea.
Carcinoma, Renal Cell* ; Cohort Studies ; Demography ; Follow-Up Studies ; Glomerular Filtration Rate ; Hemorrhage ; Humans ; Ischemia ; Kidney Neoplasms ; Korea ; Nephrectomy* ; Outcome Assessment (Health Care)

Lipids, which along with carbohydrates and proteins are among the most important nutrients for the living organism, have a variety of biological functions that can be applied widely in biomedicine. A fatty acid, the most fundamental biological lipid, may be classified by length of its aliphatic chain, and the short-, medium-, and long-chain fatty acids and each have distinct biological activities with therapeutic relevance. For example, short-chain fatty acids have immune regulatory activities and could be useful against autoimmune disease; medium-chain fatty acids generate ketogenic metabolites and may be used to control seizure; and some metabolites oxidized from long-chain fatty acids could be used to treat metabolic disorders. Glycerolipids play important roles in pathological environments, such as those of cancers or metabolic disorders, and thus are regarded as a potential therapeutic target. Phospholipids represent the main building unit of the plasma membrane of cells, and play key roles in cellular signaling. Due to their physical properties, glycerophospholipids are frequently used as pharmaceutical ingredients, in addition to being potential novel drug targets for treating disease. Sphingolipids, which comprise another component of the plasma membrane, have their own distinct biological functions and have been investigated in nanotechnological applications such as drug delivery systems. Saccharolipids, which are derived from bacteria, have endotoxin effects that stimulate the immune system. Chemically modified saccharolipids might be useful for cancer immunotherapy or as vaccine adjuvants. This review will address the important biological function of several key lipids and offer critical insights into their potential therapeutic applications.