Objective To study the effects of ? blocker on heart rate variability (HRV) of dilated cardiomyopathy and ? receptor sentivity and cardiac function.Methods HRV was analyzed by use of Holter monitoring and isopnenaline sensitivity test was performed in patients with dilated cardiomyopathy.CD 25 was measured.Cardiac function was measured by use of ultrasonography.Results SDNN,LF,HF and HRVI in the treatment group were increased compared with those before treatment(P