1.Effect of Fish Oil-based Intravenous Fat Emulsion with Parenteral Nutrition in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation.
Ji Hyeong CHOE ; Young Joo LEE ; Hye Jung BAE ; Sun Hoi JUNG ; Hyeon Joo HAHN ; Yungil KOH
Journal of Clinical Nutrition 2016;8(1):29-35
PURPOSE: Omega-3 fatty acid is known for immunonutrition in that it has anti-inflammatory properties and improves the patients' immune function. The objective of this study was to determine the effects of a fish oil-based lipid emulsion for adult patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT). METHODS: This was a retrospective study of 90 adult allogeneic HSCT patients from July 2011 to June 2015. The patients were divided into two groups according to the lipid type provided; fish oil group (FO group, n=55) and non-fish oil group (NFO group, n=35). The demographics, parenteral nutrition and lipid emulsion duration, length of hospital stay (LOS), weight change, 30 day mortality, survival period, incidence of acute graft-versus-host disease (aGVHD), neutropenic fever, sepsis, and re-hospitalization were collected from the electronic medical records. RESULTS: The patients' characteristics including age, sex, body mass index, and underlying disease were similar in the two groups. The incidence of aGVHD and infectious complications, mortality, LOS, re-hospitalization were also similar. The FO group showed weight gains, whereas the NFO group showed weight loss (FO vs. NFO=0.34% vs. -1.08%, P=0.245). CONCLUSION: The clinical outcomes were similar in the two groups but there was a tendency for gain weight in the FO group. A large, well designed study, and a dosing study will also be needed to determine the optimal dose range for HSCT patients.
Adult
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Body Mass Index
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Demography
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Electronic Health Records
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Fatty Acids
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Fever
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Fish Oils
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Graft vs Host Disease
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Hematopoietic Stem Cell Transplantation*
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Hematopoietic Stem Cells*
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Humans
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Incidence
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Length of Stay
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Mortality
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Parenteral Nutrition*
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Retrospective Studies
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Sepsis
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Weight Gain
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Weight Loss