Objective To explore the efficacy of omeprazole combined with endoscopic hemostatic clip for peptic ulcer and bleeding. Methods 98 patients with peptic ulcer and hemorrhage treated in our hospital from October 2017 to October 2018 were selected and divided into two groups according to the treatment method, the observation group and the control group, 49 cases in each group. The control group was treated with intravenous injection of omeprazole. The observation group was treated with omeprazole combined with endoscopic hemostatic clip. The clinical efficacy, hemostasis and rebleeding, pH change of gastric juice and adverse reactions were compared between the two groups. Results The total effective rate of observation group was 95.92％, which was significantly higher than that of the control group (77.55％, P <0.05). The time of hemostasis and hospitalization in the observation group was significantly shorter than that of the control group, and the rebleeding rate was significantly lower than that of the control group (P<0.05). The pH value of fasting gastric juice in the observation group was significantly higher than that in the control group at 12 h and24 h after treatment (P<0.05). The incidence of adverse reactions such as abdominal pain, nausea and rash in the obser vation group was not significantly different from that in the control group (P>0.05). Conclusion Omeprazole combined with endoscopic hemostatic clip for the treatment of peptic ulcer and bleeding can obtain satisfactory results, with rapid and complete hemostasis, which can effectively promote the repair of damaged mucosa, reduce the rate of rebleeding, shorten the treatment time, with low incidence of adverse reactions, thus it has positive clinical significance.