No abstract available.
DNA* ; Humans* ; Polymerase Chain Reaction*

It is well known that bloody cerebrospinal fluid(BCSF) obtained from patient with subarachnoid hemorrhage will contracts isolated brain arteries, but the effects of non-bloody CSF(non-BCSF), which does not contain blood components, has not been reported yet. In this study, CSFs were obtained from 12 patients hospitalized at the Department of Neurosurgery, Chonnam University Hospital from February to September 1994. Among the CSFs from these 12 patients, 3 cases were bloody and 9 cases were not. It was found that all BCSFs produced marked contractions in ring preparations of porcine isolated basilar and circle of Willis arteries. The non-BCSFs fell into two groups:one which contracted the preparations in a volume-dependent fashion(30-1000 microliter) and the other did not. The purpose of this study was to investigate the mechanism(s) of contractile response to the first group on-BCSF in the porcine isolated brain artery. Concentration-dependent contractions induced by KCl were not affected by the pretreatment with 500 microliter non-BCSF, while contraction induced by 5-hydroxytryptamine(5-HT) and phenylephrine(PE) were significantly potentiated by the same pretreatment of non-BCSF. Although volume-dependent contractions induced by the non-BCSF were not affected by the pretreatment with 10(-6) M phentolamine and 10(-4) M L-NAME, the contractions was significantly attenuated by the presence of 10(-6) M indomethacin and nimodipine. It was also found that the contraction induced by prostaglandin F2alpha(PGF2alpha) was relaxed by nitroprusside and atriopeptin(ANP) in a concentration-dependent manner and such relaxations were not affected by nitroprusside and ANP were not affected in the presence of 500 microliter non-BCSF. Above observations suggest that components, of non-BCSF from patients with brain lesion contains an unknown substance(s) that induces contraction of porcine isolated brain arteries and the above contractile effect involves the extracellular calcium influx and/or cyclooxygenaseprostaglandin system but not the NO-guanylate cyclase system.
Arteries* ; Atrial Natriuretic Factor ; Brain* ; Calcium ; Cerebrospinal Fluid* ; Circle of Willis ; Humans ; Indomethacin ; Jeollanam-do ; Neurosurgery ; NG-Nitroarginine Methyl Ester ; Nimodipine ; Nitroprusside ; Phentolamine ; Relaxation ; Subarachnoid Hemorrhage

A case of leiomyoma arising from the urinary bladder in a 34-year-old woman is presented.
Adult ; Female ; Humans ; Leiomyoma* ; Urinary Bladder*

Background: For acute ischemic stroke (AIS) patients with history of prior stroke (PS) and diabetes mellitus (DM), intravenous recombinant tissue plasminogen activator (IV-tPA) therapy in the 3- to 4.5-hour window is off-label in Korea. This study aimed to assess the safety and efficacy of IV-tPA in these patients. Methods: Using data from a prospective multicenter stroke registry between January 2009 and March 2021, we identified AIS patients who received IV-tPA in the 3- to 4.5-hour window, and compared the outcomes of symptomatic intracranial hemorrhage (SICH), 3-month mortality, 3-month modified Rankin Scale (mRS) score 0-1 and 3-month mRS distribution between patients with both PS and DM (PS/DM, n=56) versus those with neither PS nor DM, or with only one (non-PS/DM, n=927). Results: The PS/DM group versus the non-PS/DM group was more likely to have a prior disability, hypertension, hyperlipidemia, coronary heart disease and less likely to have atrial fibrillation. The PS/DM and the non-PS/DM groups had comparable rates of SICH (0% vs. 1.7%; p>0.999) and 3-month mortality (10.7% vs. 10.2%; p=0.9112). The rate of 3-month mRS 0-1 was non-significantly lower in the PS/DM group than in the non-PS/DM group (30.4% vs. 40.7%; adjusted odds ratio [95% confidence interval], 0.81 [0.41-1.59]). Conclusions In the 3- to 4.5-hour window, AIS patients with PS/DM, as compared to those with non-PS/DM, might benefit less from IV-tPA. However, given the similar risks of SICH and mortality, IV-tPA in the late time window could be considered in patients with both PS and DM.