The present study was carried out to investigate the incidence and clinical features of neonatal skin abnormalities. Six hundred eight neonates were examined in Korea University Guro Hospital from May 1988 to January 1989 and the results were summarized as follows : 1. Stork bite and salmon patch were observed in 24.5%, occurring most frequently in the nape and eyelid. 2. Portwine stains were observed in 0.3%. 3, Strawberry hemsngioma was observed in 0.3%, one case showed typical elevated lesion. 4. Morgolian spots were observed in 68.6%, occurring rnost frequently in the sacro-coccygeal region. There was no difference in sex. 5. Pigmented nevi were observed in 2.1%. Female was more frequent than male. 6. Erythema toxicum neonatorum was observed in 28.1%, occurring most frequently in the trunk. 7. Nevus sebaceus was observed in 0.2%. 8. Skin tags were observed in 1.6%. 9. Cutis marmorata was observed in 3.1%. 10. Accessory auricles were observed in 0.3% and one case was bilateral.
Coloring Agents ; Erythema ; Eyelids ; Female ; Fragaria ; Humans ; Incidence ; Infant, Newborn ; Korea ; Male ; Nevus ; Nevus, Pigmented ; Salmon ; Skin Abnormalities ; Skin*

In the present study, we have tried to isolate and identify herpes simplex virus type 2(HSV 2) from clinical specirnens, which were inoculated into Vero cell line and grown. Eight strains of viruses were isolated from 20 suspected cases diagnosed from the pr ivate clinics in Seoul. Viruses isolated from 4 rnale and 1 female cases with active lesion were identified to the HSV 2 by indirect immunofluorescence using monoclonal antibody to HSV-2. In addition, morphology of the isolated viruses were observed under electron microscope.
Female ; Fluorescent Antibody Technique, Indirect ; Herpes Simplex* ; Herpesvirus 2, Human* ; Humans ; Seoul ; Simplexvirus* ; Vero Cells

PURPOSE: Hemodynamically significant patent ductus arteriosus (PDA) may increase the mortality of premature infants who received ventilator care by aggravating hypoxia, acidosis, pulmonary edema and hypotension. The risk factors for PDA in premature infants are low gestational age, infusion of excessive fluid, and severity of neonatal respiratory distress syndrome. We studied the risk factors of PDA in very low birth weight infants (VLBW) to establish a guideline for the treatment. METHODS: VLBW infants who were born at Severance Hospital, Yonsei Medical Center from January, 1989 through December, 1995 and survived for at least 5 days with ventilator care were recruited for this study. Patent ductus arteriosus was diagnosed according to the clinical diagnostic criteria of Yeh (Yeh et al, 1981b). Thirty six infants had diagnosed as PDA (PDA group), and thirty seven infants who had not PDA were selected as control. Both groups of infants received restrictive fluid therapy. RESULTS: 1) Gestational age, sex, Apgar score, administration of surfactant, mode of delivery, toxemia and use of antenatal dexamethasone were similar between PDA and control infants. 2) In PDA group, ventilatory index and duration of vetilator care were significantly greater (P<0.05), and a/ApO2 was significantly lower than control group (P<0.05). There was no difference in peak inspiratory pressure at initial setting, the highest peak inspiratory pressure and mean airway pressure during ventilator care. 3) During the first 3 days of life, the urine output was similar between groups. On the 4th and 5th days of life, PDA group had significantly reduced urine ouput compared with control (on day 4; 2.6+/-1.1 ml/kg/h vs. 3.2+/-1.2ml/kg/h, P<0.05; on day 5, 2.9+/-1.4ml/kg/h vs. 3.6+/-1.6ml/kg/h, P<0.05) . 4) The percent weight loss compared to birth weight was siginificantly lower in PDA group (12.5% vs. 15.1%, P<0.05). 5) The PDA group had higher incidences of bronchpulmonary dysplasia and intraventricular hemorrhage (P<0.05). CONCLUSION: Among Vlnfants who received restrictive fluid therapy during the first 5 days of life, infants with PDA had reduced urine output and percent weight loss than control group.
Acidosis ; Anoxia ; Apgar Score ; Birth Weight ; Dexamethasone ; Ductus Arteriosus* ; Ductus Arteriosus, Patent ; Fluid Therapy ; Gestational Age ; Hemorrhage ; Humans ; Hypotension ; Incidence ; Infant* ; Infant, Newborn ; Infant, Premature ; Infant, Very Low Birth Weight* ; Mortality ; Pulmonary Edema ; Respiratory Distress Syndrome, Newborn ; Risk Factors* ; Toxemia ; Ventilators, Mechanical ; Weight Loss

No abstract available.
Animals ; Antlers* ; Lipid Peroxidation* ; Liver*

Drug-induced thrombocytopenia and purpura have boon developed by many various agents. Rifampin and Pyrazinamide have been known as bactericidal antituberculous drugs, but, the above side effects have been a problem. Especially, hematologic side effects art fatal to patients occasionally. Rifampin-induced thrombocytopenia and purpura have been well known, also, pyrazinamide-induced thrombocytopenia have been reported. A new quilonone agent Ciprofloxacin, has been commonly used in clinics now, but it's side effects are not known well. So, we report a case of a 23-year-old female with thrombocytopenia and purpura after taking Rifampin, Pyrazinamide, and Ciprofloxacin as antituberculous agents.
Ciprofloxacin* ; Female ; Humans ; Purpura* ; Pyrazinamide* ; Rifampin ; Thrombocytopenia* ; Young Adult

STATEMENT OF PROBLEM: One of the common problems of dental implant prosthesis is the loosening of the screw that connects each component, and this problem is more common in single implant-supported prostheses with external connection. PURPOSE: The purpose of this study was to examine the changes of detorque values of abutment screws with external connection in different abutment heights. MATERIALS AND METHODS: After cyclic loading on three different abutment heights, detorque values were measured. Abutments were retained with titanium abutment screws tightened to 30 Ncm (30.5 kgmm) with digital torque gauge as recommended by the manufacturer. Replacing abutments, implants and titanium abutment screws with new ones at every measurement, initial detorque values were measured six times. In measuring detorque values after cyclic loading, Avana Cemented Abutments of 4.0 mm collar, 7.0 mm height (Osstem Co., Ltd., Seoul, Korea) were used with three different lengths of 5.0, 8.0, 11.0 mm. Shorter abutments were made by milling of 11.0 mm abutment to have the same force-exercised area of 4.5 mm diameter. Sine curve force (20N-320N, 14Hz) was applied, and detorque values were measured after cyclic loading of 2 million times by loading machine. Detorque values of initial and after-loading were measured by digital torque gauge. One-way ANOVA was employed to see if there was any influence from different abutment heights. RESULTS: The results were as follows : 1. The initial detorque value was 27.8+/-0.93 kgmm, and the ratio of the initial detorque value to the tightening torque was 0.91(27.8/30.5). 2. Measured detorque values after cyclic loading were declined as the height of the abutment increased, that was, 5.0 mm; 22.3+/-0.82 kgmm, 8.0 mm; 21.8+/-0.93 kgmm, and 11.0 mm; 21.3+/-0.94 kgmm. 3. One-way ANOVA showed no statistically significant differences among these (p> 0.05). 4. Noticeable mobility at the implant-abutment interface was not observed in any case after cyclic loading at all.
Dental Implants ; Prostheses and Implants* ; Seoul ; Titanium ; Torque

PURPOSE: This research sought to identify the utility value of chest computed tomography (CT) when it comes to the diagnosis of lung metastasis in cases of colorectal cancer. METHODS: From September 2004 to January 2008, 266 patients who were treated for colorectal cancer at Department of Surgery, Hanyang University College of Medicine, were divided into two groups: one that underwent preoperative and postoperative periodical chest CT (periodical inspection group, PIG; May 2006 to January 2008, 135 patients) and one that did not undergo periodical chest CT (non-periodical inspection group, NPIG; September 2004 to April 2006, 131 patients) for comparison. RESULTS: The overall lung metastasis diagnosis rates did not manifest any significant difference. The times to diagnose lung metastasis patients were 6.3 months and 15.7 months for the PIG and the NPIG, respectively (P = 0.022). The size of the metastatic lung nodule was smaller in the PIG than in the NPIG (< 1 cm in 9/9 patients vs. < 1 cm in 6/9 patients in the PIG and the NPIG, respectively; P = 0.02). A solitary lung metastasis was more frequently found in the PIG (5/9 patients) than in the NPIG (1/11 patients) (P = 0.024). During the follow-up period, 100% (2/2 patients) and 60% (3/5 patients) of the patients in the PIG and the NPIG, respectively, with stage III cancer underwent a lung metastasectomy (P = 0.002). CONCLUSION: Chest CT enables early diagnosis with a smaller size and a lower number of lung metastases in patients with colorectal cancer. Moreover, pulmonary the rate of the pulmonary resection for selected patients may be improved. However, the contribution of chest CT to increasing the survival rate must be investigated in a prospective randomized study.
Colorectal Neoplasms ; Early Diagnosis ; Follow-Up Studies ; Humans ; Lung ; Metastasectomy ; Neoplasm Metastasis ; Prospective Studies ; Survival Rate ; Thorax

No abstract available.
Coronary Artery Disease* ; Coronary Vessels* ; Humans ; Kidney Failure, Chronic*

Recently, the survival rates of extremely low-birth-weight (ELBW) infants have improved with the development of neonatal intensive care. However, these infants were susceptible to intestinal perforation due to prematurity, fluid restriction, and injection of indomethacin, etc. Because of the risks of transportation, anesthesia and surgery itself, peritoneal drainage has been compared with laparotomy. Through our experience, we investigate the usefulness of peritoneal drainage retrospectively. From 1997 to 2007, six ELBW (M:F=5:1) underwent primary peritoneal drainage for intestinal perforation. Their median birth weight was 685 g (405~870) and gestational age was 25(+1) weeks (24(+3)~27(+0)). We noticed the intestinal perforation at median 10.5 days (8~18) after birth, and placed Penrose drain or Jackson-Pratt drain through right lower quadrant incision under local anesthesia. The cause of intestinal perforation was necrotizing enterocolitis in one patient, but that of the others was not clear. Three patients who showed normal platelet count and stable vital signs recovered uneventfully. Two patients (birth weight less than 500 g) who showed unstable vital signs and low platelet count (12,000 / mm3 to 30,000 / mm3) expired despite aggressive resuscitation. One patient required laparotomy due to persistent intestinal obstruction after drain removal and survived. Our experience shows that peritoneal drainage was an acceptable treatment for ELBW infants and the prognosis was related to vital sign and platelet count at the time of intestinal perforation, and birth weight.
Anesthesia ; Anesthesia, Local ; Birth Weight ; Drainage ; Enterocolitis, Necrotizing ; Gestational Age ; Humans ; Indomethacin ; Infant ; Infant, Low Birth Weight ; Infant, Newborn ; Intensive Care, Neonatal ; Intestinal Obstruction ; Intestinal Perforation ; Laparotomy ; Parturition ; Platelet Count ; Prognosis ; Resuscitation ; Retrospective Studies ; Survival Rate ; Transportation ; Vital Signs

No abstract available.
Dialysis* ; Humans ; Kidney Failure, Chronic* ; Lipid Metabolism* ; Lipoprotein(a)*