1.Two Cases of Primary Biliary Cirrhosis.
Hyeog Man KWON ; Jae Hyun CHO ; Yung Tak KIM ; Won Yung TAK ; Eun Whee PARK ; Yung Oh KWEON ; Sung Guk KIM ; Yong Whan CHOI ; Joon Mo JUNG
Korean Journal of Medicine 1999;56(3):367-372
Primary biliary cirrhosis(PBC) is a chronic cholestatic liver disease of unknown origin. The small and medium sized intrahepatic bile ducts are destroyed by an inflammatory process, which, it has been suggested, is of the autoimmune type. It is strongly associated with the presence of antimitochondrial antibodies, predominantly IgM and IgG. The liver changes are classified into four stages, of which stage IV represents the development of cirrhosis, which required orthotropic liver transplantation in the longrun. The prevalence rates was reported 128 per millon in Sweden , but the disease is relatively rare in Oriental area. In medical treatment, long-term administration of ursodeoxycholic acid improves both clinical and biochemical signs, slows the progression of the disease and reduces the complication requiring liver transplantation. We report two cases of PBC, one with histologically proven cirrhosis, and the other with bile duct destruction consistent with stage III and hypothyroidism.
Antibodies
;
Bile Ducts
;
Bile Ducts, Intrahepatic
;
Fibrosis
;
Hypothyroidism
;
Immunoglobulin G
;
Immunoglobulin M
;
Liver
;
Liver Cirrhosis, Biliary*
;
Liver Diseases
;
Liver Transplantation
;
Prevalence
;
Sweden
;
Ursodeoxycholic Acid
2.Exertional Rhabdomyolysis after Spinning.
Youjin JEONG ; Hyuk Jung KWEON ; Eun Jung OH ; Ah Leum AHN ; Jae Kyung CHOI ; Dong Yung CHO
Korean Journal of Family Medicine 2016;37(6):356-358
Any strenuous muscular exercise may trigger rhabdomyolysis. We report an episode of clinically manifested exertional rhabdomyolysis due to stationary cycling, commonly known as spinning. Reports of spinning-related rhabdomyolysis are rare in the English literature, and the current case appears to be the first such case reported in South Korea. A previously healthy 21-year-old Asian woman presented with severe thigh pain and reddish-brown urinary discoloration 24–48 hours after attending a spinning class at a local gymnasium. Paired with key laboratory findings, her symptoms were suggestive of rhabdomyolysis. She required hospital admission to sustain renal function through fluid resuscitation therapy and fluid balance monitoring. Because exertional rhabdomyolysis may occur in any unfit but otherwise healthy individual who indulges in stationary cycling, the potential health risks of this activity must be considered.
Acute Kidney Injury
;
Asian Continental Ancestry Group
;
Female
;
Humans
;
Korea
;
Resuscitation
;
Rhabdomyolysis*
;
Thigh
;
Water-Electrolyte Balance
;
Young Adult
3.Exertional Rhabdomyolysis after Spinning.
Youjin JEONG ; Hyuk Jung KWEON ; Eun Jung OH ; Ah Leum AHN ; Jae Kyung CHOI ; Dong Yung CHO
Korean Journal of Family Medicine 2016;37(6):356-358
Any strenuous muscular exercise may trigger rhabdomyolysis. We report an episode of clinically manifested exertional rhabdomyolysis due to stationary cycling, commonly known as spinning. Reports of spinning-related rhabdomyolysis are rare in the English literature, and the current case appears to be the first such case reported in South Korea. A previously healthy 21-year-old Asian woman presented with severe thigh pain and reddish-brown urinary discoloration 24–48 hours after attending a spinning class at a local gymnasium. Paired with key laboratory findings, her symptoms were suggestive of rhabdomyolysis. She required hospital admission to sustain renal function through fluid resuscitation therapy and fluid balance monitoring. Because exertional rhabdomyolysis may occur in any unfit but otherwise healthy individual who indulges in stationary cycling, the potential health risks of this activity must be considered.
Acute Kidney Injury
;
Asian Continental Ancestry Group
;
Female
;
Humans
;
Korea
;
Resuscitation
;
Rhabdomyolysis*
;
Thigh
;
Water-Electrolyte Balance
;
Young Adult
4.Association of the Metabolic Syndrome and Bone Mineral Density in Postmenopausal Women.
Jong Chang PARK ; Hyuk Jung KWEON ; Yun Kyo OH ; Hyun Jin DO ; Seung Won OH ; Youl Lee LYM ; Jae Kyung CHOI ; Hee Kyung JOH ; Dong Yung CHO
Korean Journal of Family Medicine 2010;31(1):9-15
BACKGROUND: The metabolic syndrome (MS) is a cluster of risk factors of cardiovascular disease. The association between components of the MS and bone mineral density has been researched, but no prior studies have directly evaluated the association with the metabolic syndrome and bone mineral density in Korea. METHODS: We evaluated postmenopausal women who had visited a university hospital from November 2006 to October 2007. Data on their lifestyle, current medical diseases and medications were collected from medical records. Height, body weight, waist circumference and serum lipid profiles were measured. RESULTS: The prevalence of metabolic syndrome was 21.8% in this study. In adjusted analysis including age and other factors, only waist circumference had a close correlation with bone mineral density of femur and lumbar vertebral body (P < 0.05). The bone mineral density of femur and lumbar vertebral body had no correlation with the presence of metabolic syndrome. When stratified by body mass index, corrected bone mineral density revealed no significant correlation with the presence of metabolic syndrome. CONCLUSION: The bone mineral density of postmenopausal women with metabolic syndrome has highly influenced by obesity, especially by abdominal obesity.
Body Height
;
Body Mass Index
;
Bone Density
;
Cardiovascular Diseases
;
Female
;
Femur
;
Humans
;
Life Style
;
Medical Records
;
Obesity
;
Obesity, Abdominal
;
Osteoporosis
;
Prevalence
;
Risk Factors
;
Waist Circumference
5.Association of the Metabolic Syndrome and Bone Mineral Density in Postmenopausal Women.
Jong Chang PARK ; Hyuk Jung KWEON ; Yun Kyo OH ; Hyun Jin DO ; Seung Won OH ; Youl Lee LYM ; Jae Kyung CHOI ; Hee Kyung JOH ; Dong Yung CHO
Korean Journal of Family Medicine 2010;31(1):9-15
BACKGROUND: The metabolic syndrome (MS) is a cluster of risk factors of cardiovascular disease. The association between components of the MS and bone mineral density has been researched, but no prior studies have directly evaluated the association with the metabolic syndrome and bone mineral density in Korea. METHODS: We evaluated postmenopausal women who had visited a university hospital from November 2006 to October 2007. Data on their lifestyle, current medical diseases and medications were collected from medical records. Height, body weight, waist circumference and serum lipid profiles were measured. RESULTS: The prevalence of metabolic syndrome was 21.8% in this study. In adjusted analysis including age and other factors, only waist circumference had a close correlation with bone mineral density of femur and lumbar vertebral body (P < 0.05). The bone mineral density of femur and lumbar vertebral body had no correlation with the presence of metabolic syndrome. When stratified by body mass index, corrected bone mineral density revealed no significant correlation with the presence of metabolic syndrome. CONCLUSION: The bone mineral density of postmenopausal women with metabolic syndrome has highly influenced by obesity, especially by abdominal obesity.
Body Height
;
Body Mass Index
;
Bone Density
;
Cardiovascular Diseases
;
Female
;
Femur
;
Humans
;
Life Style
;
Medical Records
;
Obesity
;
Obesity, Abdominal
;
Osteoporosis
;
Prevalence
;
Risk Factors
;
Waist Circumference
6.Relations between the Dietary Habits and Components of the Metabolic Syndrome in Premenopausal Women.
Eun Jung OH ; Hee Kyung JOH ; Ran LEE ; Hyun Jin DO ; Seung Won OH ; Youl Lee LYM ; Jae Kyung CHOI ; Hyuk Jung KWEON ; Dong Yung CHO
Journal of the Korean Academy of Family Medicine 2008;29(10):746-761
BACKGROUND: In these days the metabolic syndrome threatens many people of Korea. Several studies have suggested that the dietary habits are associated with the risk of the metabolic syndrome. The purpose of this study was to find out relations between the components of the metabolic syndrome and the dietary habits. METHODS: The subjects of this study included 1,005 non-smoking premenopausal females aged from 20 to 49 years old who visited the health promotion center of a university hospital. Dietary questionnaire was composed of dietary habits and specific food intake frequency during the past 3 months. RESULTS: The subjects who had more than one metabolic components were 361 (36%), and those who had the metabolic syndrome was 35 (3.5%). After multivariate logistic analysis adjusted with age, BMI, smoking status, alcohol intake, and exercise, the abdominal obesity risk was significantly increased in those who had irregular meals (P for trend= 0.049), skip meals (P for trend=0.050), faster meal time (P=0.017), and intake of saturated fat more frequently (P=0.043). The abdominal obesity risk was significantly increased in those who overate or binged eating 7gt; or =3 times/week than <1 time/week {OR (95% CI), 2.49 (1.07~5.80)}, intake fruit <1 time/week than 6~7 times/week {OR (95% CI), 4.46 (1.20~16.54)}. A risk for high blood pressure was significantly increased in those who had breakfast 1~2 times/week than those had it 6~7 times/week {OR (95% CI), 1.91 (1.07~3.42)}. The risk for impaired fasting glucose was significantly increased in those had breakfast <1 time/week than those who had 6~7 times/week {OR (95% CI), 2.27 (1.20~4.28), P for trend=0.018}. CONCLUSION: There was a correlation between dietary habits and metabolic syndrome components. Among the dietary habits, irregular meals, skipping breakfast, skipping meals, fast meal time, overeating or binge eating tendency, low intake of fruits and high intake of saturated fat were associated with the risk of the metabolic syndrome components.
Aged
;
Breakfast
;
Bulimia
;
Eating
;
Fasting
;
Female
;
Food Habits
;
Fruit
;
Glucose
;
Health Promotion
;
Humans
;
Hyperphagia
;
Hypertension
;
Korea
;
Meals
;
Obesity, Abdominal
;
Smoke
;
Smoking
;
Surveys and Questionnaires
7.Non-alcoholic Fatty Liver Disease and Chronic Kidney Disease in Koreans Aged 50 Years or Older.
Ah Leum AHN ; Jae Kyung CHOI ; Mi Na KIM ; Seun Ah KIM ; Eun Jung OH ; Hyuk Jung KWEON ; Dong Yung CHO
Korean Journal of Family Medicine 2013;34(3):199-205
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD) share common pathogenic mechanisms and many risk factors, and both are linked to an increased risk of cardiovascular diseases. The aim of this study was to assess the association between NAFLD and CKD according to the presence of hypertension and diabetes mellitus in Koreans aged 50 years or older. METHODS: A cross-sectional study of 1,706 subjects who received their routine health examination was conducted between May 2008 and April 2010 at Konkuk University medical center. Biochemical tests for liver and abdominal ultrasonography were performed. CKD was defined as either proteinuria or glomerular filtration rate < or =60 mL/min per 1.73 m2. RESULTS: Among the 1,706 subjects, There were 545 (31.9%) with non-alcoholic fatty liver disease and 424 (24.9%) with chronic kidney disease. In univariate logistic regression analysis, NAFLD was significantly associated with CKD (odds ratio [OR], 1.69; 95% confidence interval [CI], 1.34 to 2.12). In multivariate logistic regression analysis adjusted for age, sex, current smoking, abdominal obesity, aspartate aminotransferases, alanine aminotransferases, gamma-glutamyltransferase, hypertension, diabetes mellitus, hypertriglyceridemia, and low high-density lipoprotein cholesterol, NAFLD was associated with CKD (adjusted OR, 1.68; 95% CI, 1.27 to 2.24). This relationship remained significant after classification according to the presence of hypertension or diabetes mellitus. CONCLUSION: NAFLD diagnosed by ultrasonography was significantly associated with CKD in Koreans aged 50 years or older.
Academic Medical Centers
;
Aged
;
Alanine
;
Aspartate Aminotransferases
;
Cardiovascular Diseases
;
Cholesterol
;
Cross-Sectional Studies
;
Diabetes Mellitus
;
Fatty Liver
;
gamma-Glutamyltransferase
;
Glomerular Filtration Rate
;
Humans
;
Hypertension
;
Hypertriglyceridemia
;
Lipoproteins
;
Liver
;
Logistic Models
;
Obesity, Abdominal
;
Proteinuria
;
Renal Insufficiency, Chronic
;
Risk Factors
;
Smoke
;
Smoking
;
Transaminases
8.Performance of the AUDIT Alcohol Consumption Questions (AUDIT-C) and AUDIT-K Question 3 Alone in Screening for Problem Drinking.
Jeong Hwan SEONG ; Chang Hun LEE ; Hyun Jin DO ; Seung Won OH ; Youl Lee LYM ; Jae Kyung CHOI ; Hee Kyung JOH ; Kyuk Jung KWEON ; Dong Yung CHO
Korean Journal of Family Medicine 2009;30(9):695-702
BACKGROUND: In the busy primary care setting, there are several limitations in applying Alcohol Use Disorders Identification Test in Korea (AUDIT-K) to screen problem drinking. Thus, for primary healthcare practice, we evaluated AUDIT-C, which covers questions from 1 to 3 in AUDIT-K, and AUDIT-K Question 3 Alone to present cut points for these two screening questionnaire according to AUDIT-K test scores. METHODS: In a university hospital, we surveyed 302 males with a drinking history via self-administered questionnaire including AUDIT-K, from November 2007 to April 2008. On the basis of total score in AUDIT-K, we divided them into four groups: normal, problem drinking, alcohol use disorder, and alcohol dependence. For each alcohol drinking behavior pattern, we drew the receiver operating characteristics (ROC) curves to present cut points for appropriate sensitivity and specificity. In addition, we compared the performance of AUDIT-C and AUDIT-K Question 3 Alone through area under the curve (AUC). RESULTS: For AUDIT-C, we designated the score 8 or more as problem drinking, 9 or more as alcohol use disorder, and 11 or more as dependence. The results of sensitivity/specificity for each group were 82%/76%, 76%/79%, 80%/86%, respectively, which were suitable for screening. For AUDIT-K Question 3 Alone, we defined the score 3 or more as problem drinking or alcohol use disorder and the score 4 as dependence. The results of sensitivity/specificity for each group were 79%/80%, 84%/67%, 85%/77%, which were appropriate for screening. For every drinking behavior group, AUDIT-C was superior to AUDIT-K Question 3 Alone in screening performance (problem drinking: 0.88 vs. respectively 0.85, alcohol use disorder: 0.86 vs. 0.82, alcohol dependence: 0.88 vs. 0.81) CONCLUSION: We confirmed that both AUDIT-C and AUDIT-K Question 3 Alone, which are more convenient and have fewer time con-straints than AUDIT-K, are reasonable screening methods for problem drinking. Thus, we recommend further drinking assessment and proper intervention for male drinkers who have scores 8 or more in AUDIT-C or 3 or more in AUDIT-K Question 3 Alone.
Alcohol Drinking
;
Alcoholism
;
Drinking
;
Drinking Behavior
;
Humans
;
Korea
;
Male
;
Mass Screening
;
Primary Health Care
;
ROC Curve
;
Sensitivity and Specificity
9.Concern in and Utilization of the Mass Media Health Information in Community-dwelling Elderly.
Hye Jung KIM ; Hee Kyung JOH ; Hyeok Kyu KWON ; Hyun Jin DO ; Seung Won OH ; Youl Lee LYM ; Jae Kyung CHOI ; Hyuk Jung KWEON ; Dong Yung CHO
Korean Journal of Family Medicine 2009;30(6):426-439
BACKGROUND: Recently, the mass media serves a major role in the public health education, but have not been proven whether they are being appropriately utilized in the elderly. The aim of this study was to identify the elderly person's concern in the mass media health information and utilization behavior. METHODS: Between March to June 2008, one to one survey with the elderly people over 60 years was performed in two elderly welfare centers, one public health center, and two secondary hospitals outpatients and inpatients in Seoul and Chungju. RESULTS: A total of 999 subjects were included. By multivariate analysis, factors significantly associated with low concern in the mass media health information were low educational level, non-exercise group, and low concern in own health (P = 0.001, 0.009, < 0.001, respectively). The most frequently utilized health information source was the mass media. By comparing the frequency of health information utilization, women, low educational level, low income, non-exercise group, underweight, low level of self-evaluated health status, and low concern in health information were significantly associated with the lowest quintile of utilization (P value: < 0.001, 0.005, 0.05, < 0.001, 0.002, 0.03, 0.005, respectively). However, the presence of chronic diseases, such as hypertension, diabetes, had no association. CONCLUSION: In community-dwelling elderly, important factors associated with concern in and utilization of the mass media health information were concern in health, self-evaluated health status, exercise status and socioeconomic factors such as education or income level, rather than comorbid chronic disease.
Aged
;
Chronic Disease
;
Female
;
Humans
;
Hypertension
;
Inpatients
;
Mass Media
;
Multivariate Analysis
;
Outpatients
;
Public Health
;
Socioeconomic Factors
;
Thinness
10.Correlation between Overactive Bladder Syndrome and Obsessive Compulsive Disorder in Women.
Keun Soo AHN ; Hyun Pyo HONG ; Hyuk Jung KWEON ; Ah Leum AHN ; Eun Jung OH ; Jae Kyung CHOI ; Dong Yung CHO
Korean Journal of Family Medicine 2016;37(1):25-30
BACKGROUND: Overactive bladder syndrome is characterized by urinary urgency, usually accompanied by Frequent urination and nocturia, with or without urgent urinary incontinence. There must be the absence of causative infection or pathological conditions. Overactive bladder syndrome is related to mental disorders, particularly depression and anxiety. However, obsessive-compulsive symptoms are investigated much less frequently. The purpose of the present study was thus to assess obsessive-compulsive symptoms in overactive bladder syndrome patients. METHODS: Fifty-seven women patients with overactive bladder syndrome and fifty-seven women without it (age matched control group) were prospectively enrolled. They completed the overactive bladder syndrome-validated 8-question screener and the Korean version of the Maudsley Obsessional-Compulsive Inventory Questionnaire at the same time they visited the clinic. Patients were compared with controls on the Korean version of the Maudsley Obsessional-Compulsive Inventory Questionnaire and its checking, tidiness, doubting, and fear of contamination components. RESULTS: Patients showed more obsessive traits than controls on the Korean version of the Maudsley Obsessional-Compulsive Inventory Questionnaire total score (P=0.006) and on the checking subscale (P=0.001). Odds ratio for the overactive bladder syndrome group's obsessive-compulsive symptoms traits (score> or =14) was 5.47 (P=0.001). The Korean version of the Maudsley Obsessional-Compulsive Inventory Questionnaire total score was associated with the overactive bladder syndrome-validated 8-question screener score in patients (P=0.03). CONCLUSION: Obsessive-compulsive symptoms may constitute an important aspect of the psychiatric profile of overactive bladder syndrome patients. The severity of obsessive-compulsive symptoms seems to be related to the degree of the overactive bladder syndrome severity. Clinicians may consider screening women with overactive bladder syndrome for obsessive-compulsive symptoms.
Anxiety
;
Depression
;
Female
;
Humans
;
Mass Screening
;
Mental Disorders
;
Nocturia
;
Obsessive-Compulsive Disorder*
;
Odds Ratio
;
Prospective Studies
;
Urinary Bladder, Overactive*
;
Urinary Incontinence
;
Urination