The prevalence of obesity among pregnant women is increasing,that include pre-pregnancy obesity and/or over gestational weight gain diagnosed by different criteria in different countries.Emerging evidance suggests that maternal obesity before and during pregnancy have not only short-term effects on both of mother and offspring,but also long-term adverse influences on offspring health.Evidence from both animal and human studies indicates that maternal obesity increases the weight and adiposity,alters body composition and increases the risk of metabolic disorders.These changes further result in the increased risk of metabolic syndrome of offspring in their later life.Further studies are required to elucidate the programming mechanisms of disease risk in the offspring as a consequence of matemal obesity.Strategies to prevent and reduce the impact of maternal obesity on long-term health of offsprings are required.

Using brain microdialysis and LC-ECD, the content of dopamine in rat brain was detected to investigate the effects of ligustrazine. A liquid chromatography-electrochemical detector method has been established and validated for the determination of dopamine in rat brain dialysate. The results indicate that ligustrazine administration by subcutaneous injection significantly increased dopamine release in rat medial prefrontal cortex, nucleus accumbens and hippocampus in a dose-related manner. The drug's effects on dopa release in rat brain could be directly detected by microdialysis combined with HPLC-ECD and this method has the preponderance over traditional neurology methods.

Objective To compare the clinical effect of femoral head replacement(FHR) and dynamic hip screwsbipolar(DHS) for femoral neck fractures in elderly patients.Methods 157 cases were randomly divided into the two groups.FHR group was treated by bipolar prosthetic replacement and DHS group was treated by dynamic hip screw fixation.The Harris effect,blood loss,operation time,shimoji time,reoperation rate and complications were com pared between the two groups.Results The excellent rate was 83.33 ％ in FHR group,that was 73.42％ in the DHS group,there was significant difference between two groups(Ridit Z =10.654,P =0.000).The operation time and Harris score in the FHR group were higher than those in DHS group,the blood loss and shimoji time in FHR group were lower than those in DHS group,the differences were statistically significant (t =16.254,P =0.000 ; t =25.511,P =0.000 ; t =20.631,P =0.000 ; t =26.584,P =0.000).The incidence rates of complication and reoperation in FHR group were 3.85％,0.00％,which were significantly lower than those in DHS group(18.99％,5.13％) (P =0.006).Conclusion FHR has significant efficacy and higher security for femoral neck fractures in elderly patients compared with DHS,it is worthy of application in clinical.

Objective: to explore the expression and clinical significance of delta N p63 protein in transitional cell carcinoma of the bladder(TCCB).Method: The immunohistochemical staining assay was conducted to detect expression of delta N p63 protein in 43 cases of TCCB and 11 cases of normal bladder epithelium.The relationship between delta N p63 protein expression and pathological types,clinical stages of TCCB was analyzed.Results:The expression rates of delta N p63 protein in TCCB and normal bladder epithelium were 100%(43/43)and 18.2%(2/11)respectively.The difference between the two groups was significant(P

Objective To study the correlation between CT imaging characteristics and prognosis of patients with cerebral hemorrhage.Methods CT imaging characteristics of 116 cerebral hemorrhage patients were analyzed,and the correlation between CT imaging characteristics of patients with cerebral hemorrhage and prognosis was studied.Results 29 cases died,and the mortality was 25.0％.The mortality of patients was obviously higher along with the increasing of translocation distance of midline (r =0.9785,P ＜ 0.05).The mortality of patients was obviously higher along with the increasing of the hematoma (r =0.9895,P ＜ 0.05).The mortality of patients who suffered from cerebral hemorrhage and breaking into ventricle was 35.5％,which was obviously higher than that of patients suffered from cerebral hemorrhage but not breaking into ventricle(x2 =3.81,P ＜ 0.05).Conclusion Translocation distance of midline,hematoma quantity,bleeding location and the mortality of patients have positive correlation.

Targeted or comprehensive culture based microbiology laboratory automation has become reality in clinical laboratory diagnosis of infectious diseases,to shorten the time for identification of microorganisms such as bacteria,yeasts and mycobacteria.Automation includes automated plating,staining,blood culture,identification and susceptibility system,matrix-assisted laser desorption/ionization time of flight mass spectrometry,and middleware for Laboratory Information System and Management Information System link.

Objective To observe the clinical effect of locking compression plate(LCP)to treat proximal humeral fractures.Methods From October.2006 to May.2008,22 proximal humeral fractures were treated with LCP (WEGO Co.Ltd,SANDONG).Results All of 22 patients were followed up for 8-22 monthes postoperatively.All fractures healed within the period of follow up without looseness of internal fixators.The average healing time was 12.6 weeks.According to Neer' s score,12 cases were excellent,8 cases were good,the other two were fair.The excellent and good rate put together was 90.9%.Conclusion Locking compression plate fixation is a simple and reliable procedure to treat proximal humeral fractures with satisfactory effects.

This paper reports the functional changes of macrophage under the effect of SF1, the first fraction of human semen separated by Sephadex G-100. Two kinds of Balb/c mouse macrophage, i. e. peri toneal macrophage (PEC-M?) and the bone marrow derived macrophage (BM-M?), were treated by SF1 in vivo (i.p. ) and in vitro. It has been proved that SF1 is a potent immunosuppressive fraction; (1) As compared with the control, the phagocytosis of SF1 treated macrophage to SRBC coated with antibody declines significantly in terms of phagocytosis rate and index (p

Objective To investigate the clinical therapeutic effect of adefovir dipivoxil on Hepatitis B virus related primary hepa-tocellular carcinoma after transcatheter hepatic arterical chemoembolization combined with radiofrequency ablation.Methods 30 pa-tients with Hepatitis B virus related primary hepatocellular carcinoma were randomly divided into study group and control group,1 5 cases in each group.All 30 patients were administrated comprehensive interventional therapy,while the study group took medicine of adefovir dipivoxil 10 mg/day additionally.Then all patients were followed up and evaluated the survival quality and mortality after operation.Results The high and medium quality survival rate were compared between two groups of patients in 48 weeks after oper-ation,and there was a significant difference (P <0.05).During 60 weeks,the high quality survival rate was different significantly (P <0.05).The mortality,and the medium quality were significantly different (P <0.05)during 72 weeks.while the difference was more significantly in the low quality survival (P <0.01).Furhtermore,the differences between the medium and low quality survival during 84 weeks and 2 years were also significantly different (P < 0.01 ).Conclusion Comprehensive interventional therapy com-bined with adefovir antiviral therapy can improve the survival quality and prolong the lifetime of patients who had Hepatitis B virus related primary hepatocellular carcinoma.

OBJECTIVE:To observe the effect and safety of small-dose argatroban vs. aspirin in the treatment of acute cerebral infarction. METHODS:136 patients with acute cerebral infarction were randomly divided into observation group and control group. All patients were given routine treatment,such as anti-intracranial pressure,oxidative stress,brain protection,oxygen,blood pres-sure,blood sugar control,anti-infective,water and electrolyte acid-base balance,etc. Based on it,control group was treated with Arginine aspirin for injection 100 mg,adding into 0.9% Sodium chloride injection 250 ml,iv,once a day. Observation group was treated with Argatroban injection 40 mg,adding into 0.9% Sodium chloride injection 500 ml,24 h continuous infusion for continu-ous 2 d,iv;then dose was decreased to 10 mg,adding into 0.9% Sodium chloride injection 100 ml,iv,once a day,for continu-ous 5 d. The course of both was 7 d. The clinic data was observed,including clinical efficacy,NIHSS(National Institutes of Health Stroke Scale)score,Bathel index scores before and after treatment,and incidence of adverse reactions. The recurrence rate of cere-bral infraction during the 2-year follow-up period was observed. RESULTS:The total effective rate in observation group was signifi-cantly higher than control group,the recurrence rates of cerebral infarction in observation group within 1 and 2 year(s)were signifi-cantly lower than control group,with significant difference(P<0.05). After treatment,the NIHSS score in 2 groups were signifi-cantly lower than before,observation group was lower than control group;Bathel score was significantly higher than before,and observation group was higher than control group,with significant differences(P<0.05). There were no significant differences in the incidence of adverse reactions between 2 groups(P>0.05). CONCLUSIONS:Based on the conventional treatment,compared with aspirin, small-dose argatroban can significantly commute the nerve function of acute cerebral infarction,and reduce the recurrence rate of cerebral infarction,with good safety.