Objective To investigate the difference of serum levels of adiponectin (APN)and its gene polymorphism +276 G/T 和-11377 C/G in Yao patients with CHD and Han CHD patients and Yao normal people in Guanxi district.Methods Yao CHD patients,Han CHD patients,Yao normal people and Han normal people,each of 100 cases were included in the study.The levels of serum adiponectin of all research object were detected by ELISA and APN+276 G/T and APN-11377 C/G genotyping were conducted by using PCR-RFLP.Results The levels of adiponectin in two groups of CHD patients were significantly lower than same race normal groups,the difference were statically significant (t=10.311,8.642,all P =0.000).The adiponectin levels of two CHD groups was not statically significant difference (t = 1.792,P =0.076);②The APN+276 G/T and APN-11377 C/G of four groups conform the Hardy-Weinberg population genetic equilibrium law (all P>0.05);③The main type of all groups APN+276 G/T was the wild type.The genotype frequencies of APN+276 G/T were no significant differences in between 4 groups (all P >0.05);④The CG and GG genotype frequency of APN-11377 C/G in two CHD groups were higher than same race normal group,the difference of Yao CHD group and Yao normal group was statically significant (χ2 =8.908,P =0.012;χ2 = 17.275,P =0.000),and the difference of Yao CHD group and Han CHD group were not statically significant (χ2 = 0.363,P = 0.834).Conclusion As with Han CHD patients,serum low APN level and APN-11377 C/G loci may be risk factors of Yao CHD patients.

Objective To investigate the change trend of liver function indicators in different types of hyperlipidemia patients. Methods From July 2014 to July 2015 ,a total of 2571 patients with hyperlipidemia and 1063 normal people(control group) were collected in this research.All patients with hyperlipidemia were divided into the hypercholesterolemia group (high TC group ,n=258) ,hypertriglyceridemia group (high TG group ,n=859) and mixed type hyperlipidemia group(n=282) ,low high-density lipo-protein cholesterol group(low HDL-c group ,n=1172).The liver function indicators of total protein (TP) ,albumin (ALB) ,alanine aminotransferase(ALT ) ,aspartate aminotransferase (AST ) ,AST/ALT and globulin (GLB ) were measured in each group. Results The TP and ALB levels in the high TC group ,mixed group and low HDL group were significantly decreased compared with the control group ,the difference was statistically significant (P<0.05).The ALT ,AST ,AST/ALT and GLB levels in the four hyperlipidemia groups had different degrees of increase as compared with the control group ,the difference was statistically signifi-cant(P<0.05).The TP and ALB levels in the mixed group and the low HDL group were significantly lower than those in the high TG group and high TC group ,the difference was statistically significant (P<0.05).The ALT level in the low HDL group was sig-nificantly higher than that in the other three groups ,the difference was statistically significant (P<0.05).The AST/ALT level in the mixed group was significantly higher than the other three groups (P<0.05).The GLB level in the high TC group was signifi-cantly higher than the other 3 groups with statistical difference (P<0.05).Conclusion Blood lipid increase may induce the liver function injury.The detection of liver function indicators in the patients with hyperlipidemia will contribute to the early detection and treatment of fatty liver.

Objective To explore clinical factors influencing fetal growth restriction (FGR) in the first three months and its preventive measures.Methods A total of 56 pregnant women with FGR in our hospital from January 2013 to December 2014 were selected (FGR group).Meanwhile 56 normal full-term pregnant women were enrolled in the control group.A questionnaire was applied to investigate the common information of the pregnant.Height,weight and body mass index of pregnant women were measured and calculated.And blood pressure was measured and hematocrit and hemoglobin levels were detected.Fetal growth in the first three months was recorded.At the same,the effect of early pregnancy factors on crown-rump length was assessed by multivariate analysis.Also,fetal growth restriction for adverse birth outcomes was evaluated.Results Age,hematocrit,hemoglobin level,educational level,smoking,drinking,folic acid supplementation,the initial delivery,diastolic blood pressure of pregnant women in FGR group and control group showed significant difference (P ＜ 0.05).Crown-rump length,head circumference at birth,birth length,birth weight and gestational age in FGR group and the control group showed a significant difference (P ＜ 0.05).Maternal age,hematocrit,hemoglobin level,smoking (≥ 10 cigarettes daily) and folic acid supplementatior had a significant impact on fetal crown-rump length (P ＜ 0.05).First-trimester fetal growth restriction could increase risk of preterm birth,low birth weight,and low gestational age at birth.Conclusion High maternal age,low education level,high hematocrit and hemoglobin levels,smoking,drinking,lack of folic acid supplements,high diastolic blood pressure are risk factors for fetal growth restriction occurred in first-trimester.Trimester fetal growth restriction can adversely affect born fetus.Therefore,effective,comprehensive prevention and control measures should be taken during pregnancy to prevent theses risk factors.

Objective To explore clinical factors influencing fetal growth restriction (FGR) in the first three months and its preventive measures.Methods A total of 56 pregnant women with FGR in our hospital from January 2013 to December 2014 were selected (FGR group).Meanwhile 56 normal full-term pregnant women were enrolled in the control group.A questionnaire was applied to investigate the common information of the pregnant.Height,weight and body mass index of pregnant women were measured and calculated.And blood pressure was measured and hematocrit and hemoglobin levels were detected.Fetal growth in the first three months was recorded.At the same,the effect of early pregnancy factors on crown-rump length was assessed by multivariate analysis.Also,fetal growth restriction for adverse birth outcomes was evaluated.Results Age,hematocrit,hemoglobin level,educational level,smoking,drinking,folic acid supplementation,the initial delivery,diastolic blood pressure of pregnant women in FGR group and control group showed significant difference (P ＜ 0.05).Crown-rump length,head circumference at birth,birth length,birth weight and gestational age in FGR group and the control group showed a significant difference (P ＜ 0.05).Maternal age,hematocrit,hemoglobin level,smoking (≥ 10 cigarettes daily) and folic acid supplementatior had a significant impact on fetal crown-rump length (P ＜ 0.05).First-trimester fetal growth restriction could increase risk of preterm birth,low birth weight,and low gestational age at birth.Conclusion High maternal age,low education level,high hematocrit and hemoglobin levels,smoking,drinking,lack of folic acid supplements,high diastolic blood pressure are risk factors for fetal growth restriction occurred in first-trimester.Trimester fetal growth restriction can adversely affect born fetus.Therefore,effective,comprehensive prevention and control measures should be taken during pregnancy to prevent theses risk factors.