1.Comparison of berberine between normal and febrile rats——pharmacokinetic study of antifebrile complex YL2000
Yunan ZHAO ; Dongming XING ; Yi DING ; Wen JIN ; Wei WANG ; Fan LEI ; Lijun DU ;
Chinese Pharmacological Bulletin 2003;0(10):-
AIM To explore pharmacokinetics of Berberine in YL2000 in normal and febrile rats. METHODS The levels of Berberine in plasma were measured through HPLC and secondary parameters were obtained by fitting the dose time data of Berberine making use of 3P87 programme. RESULTS In normal and febrile rats, the plasma concentration of Berberine was peaked at (3 4?0 3) h vs (0 3?2 1) h( P
2.New Perspectives of Chinese Medicine: Philosophic Analysis of Its Advantage-characters and Its Development in Future
Lijun DU ; Yunan ZHAO ; Fan LEI ; Weidong XIE ; Jun LI
World Science and Technology-Modernization of Traditional Chinese Medicine 2017;19(9):1435-1442
To today of its development,the tenacious vitalities of traditional Chinese medicine (TCM) beyond doubt.From this point of view,it has a positive meaning to analyze and understand TCM,from which to find its advantages and characteristics for better improvement and development of TCM-theory,so that better for the benefit of mankind.Therefore,they were discussed from the perspective of philosophy of science with the conclusion as follows:1.It is a major current Chinese medicine theory Features that the conceptual system of metaphysical nature made the organic combination of syndrome differentiation and treatment,and the Chinese herbal medicines and other therapy as a means of feedback to verify and correct TCM's theory.2.The theory of current Chinese medicine is different from the theory of TCM,because its theoretical deduction and its argument are different from the focus of ancient Chinese medicine.These development and innovation in current Chinese medicine needs to be studied and summarized.3.Chinese medicine and Western medicine should be parallel to the two medical theory systems,both of which enrich the prevention and treatment of diseases.4.As an independent medical theory system,Chinese medicine theory must also need to develop and even revolution.And this process depends on the overall level of development and improvement of science and technology.
3.Study on Synthetic Process of Roxatidine Acetate
Pengyun YANG ; Hui ZHANG ; Tongjie CHENG ; Yunan LEI
Journal of Shenyang Medical College 2016;18(3):209-210
Objective: To synthesize roxatidine acetate and its salt. Methods: Using orthogonal test method, reactant ratio was made. Roxatidine acetate was synthesized. Excel was used to synthesize data and make statistics chart. Result: Salt of roxatidine ac?etate was synthesized in four steps with overall yield of 28?8%. Conclusion: The process is moderate and simple and the production cost is low.
4.Progress of research on Maple syrup disease.
Caifei YANG ; Tao CHEN ; Xiaoguang LEI ; Yuexian LIU ; Mengyuan XU ; Dan YANG
Chinese Journal of Medical Genetics 2019;36(7):737-741
Maple syrup disease (MSUD) is a rare autosomal recessive disorder caused primarily by mutations of branched-chain keto acid dehydrogenase complex (BCKDC). BCKDC includes at least four pathogenic genes of BCKDHA, BCKDHB, DLD and DBT. The clinical manifestations of MSUD are complex, and the main symptoms at the early stage include difficulty in feeding, drowsiness, change in muscle tone and special urine flavor of maple syrup. As the disease progresses, convulsion, hypoglycemia, coma and systemic failure may occur. MSUD is easily missed or misdiagnosed during the neonatal period. This paper provides a review for recent progress made in research on MSUD including etiology, physiopathology, clinical manifestation, auxiliary examination and treatment, with a particular emphasis on genetic testing and treatment.
3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide)
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genetics
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Humans
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Maple Syrup Urine Disease
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diagnosis
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genetics
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therapy
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Mutation