1.Case of recurrent thyroid adenoma.
Chinese Acupuncture & Moxibustion 2013;33(9):855-855
Acupuncture Therapy
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Adult
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Female
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Humans
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Thyroid Neoplasms
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surgery
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therapy
2.Changes of Luteinizing Hormone, Follicle-Stimulating Hormone and Testosterone in Umbilical Vein Blood of Neonates with Different Birth Weight and Sexes
jiong-ying, ZHOU ; zi-lin, JIN ; yun-bao, MA ; qi-zhi, HE
Journal of Applied Clinical Pediatrics 2006;0(16):-
Objective To observe changes of luteinizing hormone (LH), follicle-stimulating hormone (FSH) and testosterone (T) in umbilical vein blood between male and female neonates, and assess the effect of serum LH, FSH and T on fetal growth.Methods Umbilical vein blood was obtained from 130 neonates (64 females and 66 males) in the second hospital of changshu city. According to birth weight, 130 neonates were divided into 3 groups: macrosomia (n=28), intrauterine growth restriction (IUGR) (n=31) and normal neonates (n=71). The serum levels of LH, FSH and T were measured by radioimmunoassay.Results 1.The levels of LH, FSH and T in umbilical vein blood were significantly higher in male neonates than those in females (P
3.Study on secondary metabolites of endophytic fungi Penicillium dangeardii.
Hai-ning LV ; Guang-zhi DING ; Yun-bao LIU ; Jing QU
China Journal of Chinese Materia Medica 2015;40(9):1759-1761
Endophytic fungi Penicillium dangeardii, isolated from Lysidice rhodostegia Hance root, was fermented and the secondary metabolites were studied. By means of Sephadex LH-20 column chromatography, ODS column chromatography and PHPLC over the fermented culture, 5 compounds were isolated. By using ESI-MS and NMR, the structures of the compounds were determined as N-[9-(β- D-ribofuranosyl)-9H-purin-6-yl]-L-aspartic acid (1), 3-caffeoylquinic acid (2), 4-caffeoylquinic acid (3), and 5-caffeoylquinic acid (4), 3-hydroxy-benzoic acid-4-O-β-D-glucopyranoside (5).
Biological Factors
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chemistry
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isolation & purification
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metabolism
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Endophytes
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chemistry
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metabolism
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Fabaceae
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microbiology
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Fermentation
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Molecular Structure
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Penicillium
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chemistry
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metabolism
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Secondary Metabolism
4.The study of imaging manifestations of lung neoplasms in pre-and post-treatment with CT-guided Argon-Helium cryoablation
Bao-Ping LI ; Yun-Zhi ZHOU ; Xiao-Ming YIN ; Hong-Wu WANG ; Qing-Yu ZENG ; Jian-Wei HUO ; Xin CHANG ;
Chinese Journal of Radiology 2001;0(07):-
Objective To investigate the imaging manifestations of lung neoplasms in pre- and post- treatment with CT-guided Argon-Helium cryoablation.Methods All the lung neoplasms in 96 patients have been treated with CT-guided percutaneous Argon-Helium targeted cryoablation.All patients have pre- and post-treatment CT scanning in measurement of lesion size and CT value.The CT scanning has been rerpeated afterl,3,6,12 months of treatment.Results Among total 96 cases,there are 82 cases of lung cancer and 14 cases of metastasis with 110 lesions(89 cases with single lesion,7 cases with multiple lesions).The Ar-He cryoablation has been given 103 times in total.The size of each lesion ranged from 1.2 cm to 15.0 cm in diameter with mean value of(4.0?2.5)cm,including 12 lesions less than 2 cm,51 lesions between 2— 4 cm,24 lesions between 4—6 cm,23 lesions over 6 cm.There are 25 patients whose lesions covered by iceball with 1 cm of overloaping it's margin.There are 63 lesions with diameter less than 4 cm gained 100% ablation rate,24 lesions with 4—6 cm diameter gained 95.8% ablation rate,and 23 lesions with over 6 cm diameter gained 69.6% ablation rate.The post-treatment CT show a progressively enlarged round,low density refrigerant area which clearly demarked with non- refrigerant area.The center of each refrigerant area has negative CT value,the mean decreased CT value of lesion instantly after the treatment are about 30— 50 HU with P
5.A novel regulable sutureless aortic arch prosthesis:an experimental study
Qing-Qi HAN ; Zhi-Yun XU ; Bao-Ren ZHANG ; Sheng-Dong HUANG ; Lin HAN ; Fang-Lin LU ; Zhi-Gang SUN ; Dong ZHOU ; Hong-Cheng LIU ;
Academic Journal of Second Military Medical University 1999;0(12):-
Objective:To develop a novel regulable sutureless aortic arch prosthesis and to apply it in an animal experimental study.Methods:The arch skeleton of the prosthesis was made of tandem Z-shape NiTiNOL wire;the branch skeleton was made of laser-cut NiTiNOL tube;and the whole skeleton was coated with thin ePTFE film.The blood vessel was anastomosed by di- rect ligature,needing no manual suturing.The prosthesis was applied in swine aortic arch operations under the bypass condi- tion.The practicality for surgery and the feasibility of anastomosis of the prosthesis were assessed.Results:Aortic arch opera- tions were successfully performed in 6 of the 8 experimental animals.The prostheses were easy to use,and the mean bypass time was only 10 min.The blood loss of the anastomoses was less than 100 ml within 8 h postoperatively in 5 animals;one had more blood loss due to prosthesis mismatch.Conclusion:The novel regulable sutureless aortic arch prosthesis has satisfactory practicality for surgery and reliable anastomosis,making it promising in future clinical application.
6.Advances in clinical and safety studies of phosphodiesterase 4 inhibitors
Hui-fang WANG ; You-zhi WANG ; Yun-bao ZHI ; Lin-fei ZUO ; Hui-zhen SHEN ; Zheng-wen XU ; Jin-xin WANG
Acta Pharmaceutica Sinica 2023;58(9):2601-2609
Phosphodiesterase 4 (PDE4) is an important member of the phosphodiesterase enzyme family that specifically catalyzes the hydrolysis of cyclic adenosine monophosphate (cAMP), activates the downstream phosphorylation cascade pathway by altering cAMP concentration, and is strongly associated with multiple diseases. Inhibition of PDE4 is clinically investigated as a therapeutic strategy in a broad range of disease areas, including respiratory system diseases, autoimmune disorders, central nervous system diseases, and dermatological conditions. However, the incidence of adverse reactions such as nausea and vomiting is relatively high in the marketed PDE4 inhibitors, which has stalled their clinical development. In this review, we provide an overview of the clinical progression and safety issues of the marketed PDE4 inhibitors. We also review the main causes underlying PDE4-mediated adverse effects by combining the structural analysis of the PDE4 protein, the mechanism of action of PDE4 inhibitors, and the related side effect mechanism research, aiming to provide a reference for the development of safe and effective PDE4 inhibitors.
7.Pharmacodynamic and toxicologic comparative study of crude and processed radix aristolochice.
Jin-Hua WANG ; Zhi-Min WANG ; Xu JIANG ; Bao-Yun XUE ; Chun-Ying LI
China Journal of Chinese Materia Medica 2007;32(5):428-433
OBJECTIVETo study the accumulated toxic action to bandicoot of aqueous extract of crude and processed Radix Aristolochice and the pharmacodynamic action of aqueous and alcoholic extract of crude and processed Radix Aristolochice.
METHODThe LD50 of acute toxicity to mice and chronic accumulated toxicity to bandicoots of crude and processed Radix Aristolochice were observated. Intestinal and myokinetic influence of normal and revulsive hyperactive gastrointestinal motility of mice induced by neostigmine were observated by giving aqueous extract and alcoholic extract of crude and processed Radix Aristolochice. Relieving pain and eliminating inflammation to mice also were observated.
RESULTThe LD50 of aqueous extract of crude and processed Radix Aristolochice were 146. 45, 846.06 g X kg(-1) (equivalently to crude drug) respectively by intragastric administration. Bandicoot' general condition, peripheral blood, serum, organic coefficient, histopathologic examination weren't obvious changes after 1 month administrating aqueous extract of crude and processed drug in three dose. Serum indicators-urea nitrogen, cholesterol total, alkaline phosphatase manifestly were heightened and some animals'hepatic cells, nephric tubules and mucosa emerged differently damage at histomorphology by giving crude high dose after 2 months. Above organs emerged different damage in crude middle and high dose and processed high dose after 3 months and serum indicators- creatinine, urea nitrogen manifestly were increased, the coefficients of liver, kidney and gaster manifestly were heightened. However, the toxicity of identical dose processed product was lower than that of crude one. Aqueous extract and alcoholic extract of crude and processed Radix Aristolochice could obviously inhibite normal and revulsive hyperactive gastrointestinal motility by neostigmine of mice, relieve pain in mouse, stretching and heat stimulation models and inhibite dimethyl benzene-induc mouse, auricle inflammation. Pharmacodynamic action wasnt obvious difference in same dose of crude product and processed one.
CONCLUSIONAcute toxicity and chronic accumulated toxicity are stepped down after giving processed Radix Aristolochice, but pharmacodynamic effect wasn t lower. In pharmacodynamic effect, aqueous extract can't compare with alcoholic extract in same dose.
Analgesics ; administration & dosage ; pharmacology ; toxicity ; Animals ; Anti-Inflammatory Agents ; administration & dosage ; pharmacology ; toxicity ; Aristolochia ; chemistry ; Dose-Response Relationship, Drug ; Drug Compounding ; methods ; Drugs, Chinese Herbal ; administration & dosage ; isolation & purification ; pharmacology ; toxicity ; Ear Diseases ; pathology ; prevention & control ; Female ; Gastric Mucosa ; drug effects ; Gastrointestinal Motility ; drug effects ; Hot Temperature ; Inflammation ; pathology ; prevention & control ; Lethal Dose 50 ; Male ; Mice ; Mice, Inbred ICR ; Pain ; physiopathology ; prevention & control ; Pain Measurement ; Plant Roots ; chemistry ; Plants, Medicinal ; chemistry ; Random Allocation ; Rats ; Rats, Wistar
8.Chemical constituents from herbs of Swertia mileensis.
Xu-Shan LI ; Zhi-yong JIANG ; Fu-shengi WANG ; Yun-Bao MA ; Xue-mei ZHANG ; Ji-jun CHEN
China Journal of Chinese Materia Medica 2008;33(23):2790-2793
OBJECTIVETo study the chemical constituents of Swertia mileensis.
METHODThe air-dried whole plants of S. mileensis were extracted with 50% EtOH. The EtOH extract was suspended in H20 and extracted with petroleum ether, CHCl3 and n-BuOH successively. The compounds were isolated and purified by column chromatography from the CHCl3 fraction, and identified based on spectral analyses (MS, H-NMR, 13C-NMR).
RESULTTwelve compounds were isolated from S. mileensis, and were elucidated as 1,5, 8-trihydroxy-3-methoxyxanthone (1), 1-hydroxyl-2, 3, 5, 7-tetramethoxyxanthone (2), 1-hydroxyl-3, 5, 8-trimethoxyxanthone (3), 1-hydroxyl-2, 3, 4, 6-tetramethoxyxanthone (4), 1-hydroxyl-2, 3, 4, 7-tetramethoxyxanthone (5), 1,8-dihydroxy-3, 5-dimethoxyxanthone (6), 1, 7-dihydroxy-3, 8-dimethoxyxanthone (7), 1, 3, 5, 8-tetrahydroxyxanthone (8), balanophonin (9), oleanolic acid (10), maslinic acid (11), sumaresinolic acid (12).
CONCLUSIONCompounds 1, 3, 7-9, 11 and 12 were obtained from S. mileensis for the first time.
Drugs, Chinese Herbal ; chemistry ; isolation & purification ; Swertia ; chemistry
9.Epidemiologic analysis on human plague of Sanjiangyun Area in Qinghai Province, China
Guo-jun, WANG ; Chao, LI ; Zhi-zhen, QI ; Li, WANG ; Hu, WANG ; Zu-yun, WANG ; Yi, ZHENG ; Bai-zhong, CUI ; Xiang, LI ; Bao-hong, MA
Chinese Journal of Endemiology 2008;27(2):207-209
Objective To study on epidemiologic characteristics of human plague cases in Sanjiangyuan Area,and provide theoretical basis to work out the preventive measures.Methods Based upon the epidemiology information from the human plague case data bank of Qinghai Province,human plague data were analyzed retrospectively in Sanjiangyun Area by sorting,verifying and summing up of these data,including some of case file and monitoring data.Results Except for 12 years in the period of 1960 to 2006,there were human plague cases happened every year.The morbidity occurred mainly in 12 counties of 4 states,including Yushu,Guolou,Huangnan and Hainan,and Tanggula Town of Geermu City,a total of 85 human plague episodes were occurred,resulting 238 onsets,134 deaths,and a matality rate of 56.30%.The sources of infection were respectively Himalayan mormot 27.31%(65/238),artiodactyls 14.71%(32/238),carnivora 2.10%(5/238),Lagomorpha 0.42%(1/238),the pneumonic plague patient 49.16%(117/238),and biting of flea 6.30%(15/238).The prevalent season was from May all the way to November,the peak-months were August and September.After October,the sheep as the source of infection initiating human being plague accounted for 23.53%.Among the clinical types,the most prevalent type was pneumonic type(61.34%),and the rest,glandular type(17.23%),septic type(16.81%)and other types(4.62%),but the first plague case in each epidemic was mainly the glandular plague.Conclusions In recent years,the tendency of human plague prevalence increases in Sanjiangyuan Area,it is urgent to improve and adjust the prevention and treatment measures in time.
10.Primary cutaneous T-cell lymphoma of the penis complicated by Fournier gangrene: a case report.
Zun-lin ZHOU ; Chuan-yun WANG ; Zhi-shun XU ; Bao-zhong ZHENG
National Journal of Andrology 2008;14(6):542-544
OBJECTIVETo explore the clinical presentation, pathologic characteristics, diagnosis and treatment of cutaneous T-cell lymphoma of the penis.
METHODSA 49-year-old man presented with painful swelling and inflammation of the foreskin, failed to respond to antibiotic treatment and dorsal incision, and was instead complicated by Fournier gangrene. Then he underwent debridement and pathological examination.
RESULTSPathological results indicated cutaneous T-cell lymphoma of the penis. Immunohistochemistry showed CD3 and CD45 RO to be positive, but CD30, CD79a, CD20 and HMB negative. The patient was treated by interferon alpha and ultraviolet B for 2 weeks, followed by total removal of the external genitalia because of necrosis of the corpus spongiosum, which involved the scrotum and right testis on pathological examination.
CONCLUSIONCutaneous T-cell lymphoma of the penis is a rare condition and easily mis diagnosed in the early phase. Definitive diagnosis depends on pathological study.
CD3 Complex ; analysis ; Diagnosis, Differential ; Fournier Gangrene ; etiology ; pathology ; Humans ; Immunohistochemistry ; Leukocyte Common Antigens ; analysis ; Lymphoma, T-Cell, Cutaneous ; complications ; metabolism ; pathology ; Male ; Middle Aged ; Penile Neoplasms ; complications ; metabolism ; pathology