Objective To know the TCM discipline development situation through analysis on TCM articles based on Chinese Science Citation Database (CSCD) in recent years. Methods Articles about TCM in CSCD from January 2010 to December 2015 were searched by computers. The CSCD literature analysis system was used to conduct metrological analysis from the aspects of publishing time, source journals, cited information, authors, publishing organizations, research themes, and fund support. Results The number of articles published on CSCD was increasing year by year from January 2010 to December 2015. 85.09% of articles focused on the field of general medicine. There were more than 100 CSCD journals included in TCM professional articles. 17 journals published more than 100 TCM professional articles. WANG Yong-yan academician was the author who published the most articles (121 papers). Academic output H index of six authors was more than 5. 31.52% articles in CSCD were cited. Natural Science Foundation of China (including general and youth projects) funded the highest number of articles (12.2%), reaching 1716 articles. Conclusion Analysis on articles from CSCD can outline the development situation of TCM discipline in China. In recent years, the number of TCM articles is increasing; subject integration is good; high-level teams are forming gradually; TCM discipline is developing fast. However, the citation frequency is low; scholar H index is not high; the overall level remains to be improved.

Objective To set up a method for determination of the trace amounts of aluminium(Ⅲ) in water samples. Methods Second derivative polarogaphy was used. Results In a solution of acetate buffer(HOAc-NH4OH, pH=5.8), Al(Ⅲ)reacted with Berllon Ⅲ to form a complex and a sensitive polarogaphic adsorptive wave appeared at -0.54 V(vs.SCE). By using the 2nd derivative polarogaphy measyrement, the wave height had a linear relationship with the concentration of Al(Ⅲ)in the range of 0.005-0.300 ?g/ml. The limit of detection was 3.0 ng/ml. RSDs were 5.4%-9.1%. Recovery rates were 92.7%-108.0%. Conclusion The present method is sensitive, accurate with high selectivity and can be applied to the determination of the trace amounts of Aluminium(Ⅲ) in water sample with satisfactory results.

Membrane-associated guanylate kinases (MAGUKs) is a class of postsynaptic density proteins (PSDs) in the postsynaptic dense of the postsynaptic membrane,including PSD-95,SAP-102,PSD-93,and SAP-97.MAGUK family members contain several protein binding sites,and these special binding sites are responsible for mediating a variety of signal transduction.MAGUKs participate in the occurrence and development mechanisms in central nervous system diseases,and has become a topic of general interest of neuroscience.This article briefly reviews the roles of MAGUKs in ischemic brain injury.

Apolipoprotein E (ApoE) has gene polymorphism (ε2,ε3,and ε4).It has been confirmed that ApoE structural and functional abnormlities are closely associated with the hyperlipidemia,formation of atherosclerosis,and its severity,while both hyperlipidemia and atherosclerosis are the risk factors for ischemic stroke.In recent years,although the relationship between the ApoE gene polymorphism and ischemic stroke has been extensively studied,the conclusions are not consistent.This article reviews the correlation studies between the ApoE gene polymorphism and ischernic stroke.

Cerebral small vessel disease (SVD) is an important subtype of cerebrovascular disease. It is also one of the major reasons for resulting in vascular cognitive impairment or dementia in the elderly. SVD is a small arteriovenous lesion in subcortex caused by a variety of causes, mainly causing subcortical lacunar infarction, white matter damage, microblecds and other pathological changes. There is evidence that vascular endothelial function and blood-brain barrier damage may result in small vessel structures and perivascular changes, which may be the initial factors.of causing SVD. Genetic susceptibility is also one of the risk factors that can not be ignored.

Objective To explore the influences of parent-child attachment security memory activation on college students'general attachment working model. Methods 152 college students were randomly distributed to three groups, among which there were two experimental groups accepting father-child or mother-child memory activation,and one control group accepting non-interpersonal memory activation. Results Mather-child security memory activation significantly increased subjects' scores on others-model of general attachment to females (F= 3.83;P ＜0.05), scores of mather-child security memory activation group were significantly higher than those of fatherchild group ( 7.88 ± 7.24,4.49 ± 7.53; P ＜ 0.05 ) and control group ( 7.88 ± 7.24,4.71 ± 6.83; P ＜ 0.05 ).Father-child security memory activation significantly increased subjects' scores on self-model of general attachment to males (F= 6.35; P ＜ 0.01 ), scores of father-child security memory activation group were significantly higher than that of mather-child group (6.33 ±5.39,2.44 ±6.14; P＜0.01 ) and control group (6.33 ± 5.39,2.59 ±6.10; P ＜ 0.01 ). Conclusion Parent-child attachment security memory activation have major influences on college students' general attachment working model, in which the effect of gender differences provides some inspiration for clinical interferences.

ObjectiveTo investigate the effects of alpha-lipoic acid on serum soluble intercellular adhesion molecule-1 (sICAM-1) and high sensitive-C reactive protein (hs-CRP) levels in patients with early diabetic nephropathy (DN).MethodsA total of 61 patients with early DN were randomized into treatment group (n =31 ) and control group ( n =30 ).The two groups were both treated with dietary control and oral hypoglycemic drugs or insulin.Meanwhile,the treatment group was additionally given alpha-lipoic acid 300 mg/d by intravenous infusion for 20 days.The levels of sICAM-1 and hs-CRP in each group were detected.Results The levels of sICAM-1 and hs-CRP were decreased significantly in alpha-lipoic acid treatment group after 20 days of therapy ( [ 198.03 ±23.67] μg/L vs [271.17 ±34.66] μg/L,[5.16 ±0.43] mg/Lvs [7.95 ±0.88]mg/L,P ＜0.01 ).Conclusion alpha-lipoic acid may decrease the expression of slCAM-1 and hs-CRP,and that may be one of the mechanisms to postpone the progress of early DN.

Cascade in cerebral ischemic injury may cause cholinergic dysfunction,inflammation and oxidative stress. It plays an important role in the pathological processes of vascular dementia. A large amount of basic research has confirmed that cholinesterase inhibitor and N-methyl-d-aspartate receptor inhibitor may improve cognitive function in patients with vascular dementia. However, the efficacy of these drugs has been confirmed in only a part of the patients, and their safety and efficiency have not achieved the expected results. Thus, it needs further study and exploration.

Histone deacetylases (HDACs) catalyze the deacetylation of histone and nonhistone proteins. They play important roles in regulating chromatin remodeling and gene transcription,and that aberrant chromatin remodeling and transcriptional dysregulation are associated with many neurodegenerative diseases. Preclinical studies have suggested that histone deacetylases inhibitors (HDACIs) can target diverse pathophysiologies of ischemic stroke,not only reduce neuronal damage and infarct volume,but also promote the neuronal plasticity and functional recovery after ischemia. This article mainly reviews the neuroprotective mechanisms of HDACIs in ischemic stroke.

Cocaine-and amphetamine-regulated transcript (CART), an endogenous neuropeptide, is widely distributed in human organs and tissues, such as brain, gastrointestinal tract and pancreas. It has a variety of important physiological functions, including eating and obesity, stress, mental anxiety, drug addition, and endocrine regulation. Previous studies have suggested that CART is widely distributed in the central nervous system, and it involves in the regulation of a variety of physiological processes and has some central protective effects. It is a potential neuroprotective agent. This article reviews the recent progress in research on the neuroprotective effect of CART on stroke and neurodegenerative disease and its mechanisms, as well as its therapeutic effect in central nervous system diseases.