No abstract available.
Animals ; Flowmeters* ; Magnets* ; Male ; Models, Animal* ; Penile Erection* ; Rats*

No abstract available.
Animals ; Clomipramine* ; Preoptic Area* ; Rats* ; Serotonin Uptake Inhibitors* ; Serotonin*

PURPOSE: To evaluate whether radial rigidity measured using RigiScan(R) represents the intracorporeal pressure effectively. MATERIALS AND METHODS: From January 1998 to May 1999, total of 23 patients with erectile dysfunction were evaluated by RigiScan(R) and duplex ultrasonography after the intracorporeal injection of prostaglandin E1. Peak systolic velocity and end diastolic velocity were measured by duplex ultrasonography and then the resistance index was calculated as (peak systolic velocity-end diastolic velocity)/(peak systolic velocity). Radial rigidity of penile tip and base was measured by RigiScanR . The results were analyzed statistically by PC-SPSS version 7.5. RESULTS: There were statistically significant correlations between radial rigidity of penile tip and base and the resistance index by Spearman's correlation analysis, respectively (r=0.680, p<0.001)(r=0.703, p<0.001). When radial rigidity of penile tip and base exceeded 60% of maximum, radial rigidity of penile tip and base again correlated well with the resistance index, respectively (r=0.659, p=0.020)(r=0.759, p=0.011). Based on clinically determined degree of erection, radial rigidity of penile tip and base represented the intracorporeal pressure effectively. CONCLUSIONS: Radial rigidity measured by RigiScan(R) represents the intracorporeal pressure effectively.
Alprostadil* ; Erectile Dysfunction ; Humans ; Male ; Ultrasonography

Transrectal Ultrasonography (TRUS) easily provides an accurate assessment of the seminal tract. In Magnetic Resonance Imaging(MRI) of the seminal tract, the anatomic relationships are more clearly seen and the multiplanar imaging is available, so a more definitive diagnosis can be achieved. Although TRUS and MRI have been studied extensively, the findings of TRUS have not been compared with those of MRI. We studied 29 patients who were assessed with TRUS and MRI simultaneously due to disease of the seminal tract. The findings of cystic disease were coincident between TRUS and MRI. But the small size Mullerian duct cysts were not found in TRUS but were found in MRI. Hemorrhage of the ejaculatory duct and seminal vesicle, thickened ampulla portion of vas deferens were found only in MRI. Ejaculatory duct and seminal vesicle calcification were not easily found in TRUS due to their small size. The findings of seminal vesicle atrophy, dilatation and prostatic calcification between TRUS and MRI were discrepant. In conclusion, MRI is more helpful than TRUS in the diagnosis of small Mullerian duct cyst, small ejaculatory duct calculi, small seminal vesicle calculi, hemorrhage of ejaculatory duct and seminal vesicle and thickened ampulla portion of vas eferens.
Atrophy ; Calculi ; Diagnosis* ; Dilatation ; Ejaculatory Ducts ; Hemorrhage ; Humans ; Magnetic Resonance Imaging* ; Male ; Seminal Vesicles ; Ultrasonography* ; Vas Deferens

No abstract available.
Follow-Up Studies* ; Hydronephrosis*

No abstract available.
Stroke*

PURPOSE: It is known that alpha-2 receptor is found at the presynaptic serotonergic nervous system and a consequence of increased activation of alpha-2 receptor decreases the serotonin release. So Alpha-2 blockers may have the effect on the release of serotonin. The major serotonergic innervation is found at the hippocampus. This study was performed to investigate the effect of the alpha-2 receptor blocker to serotonin release in rat hippocampus. MATERIALS AND METHODS: The hippocampus from the male rat brain was sliced. After 30 minutes preincubation in the normal buffer, the slices were incubated for 20 minutes in a buffer containing 0.1 microM[3H]5-HT for uptake, and washed. After administration of alpha 2 receptor blockers, yohimbine (10-5M), the release of [3H]5-HT into the buffer was measured, the radioactivities in each buffer and the tissue were counted and the results were expressed as a percentage of the total activity. The value of released [3H]5-HT was expressed as percent of the value at 50 minutes when a steady state of [3H]5-HT release was obtained. RESULTS: After adminstration of yohimbine (10-5M), the values(mean+/-SE, %) were 147.5+/-9.2 at 60 minutes and 143.8+/-7.3 at 70 minutes compared to the values of control group, 96.6+/-1.9 at 60 minutes and 89.6+/-2.3 at 70 minutes. The release was increased significantly after adminstration of yohimbine. CONCLUSIONS: Alpha-2 receptor blockers increased the release of serotonin. It is suggested that the consideration of the increase of serotonin release by alpha-2 receptor blockers may be helpful to understand the effect of serotonin on sexual function.
Animals ; Brain ; Hippocampus ; Humans ; Male ; Nervous System ; Radioactivity ; Rats* ; Serotonin* ; Yohimbine

No abstract available.
Animals ; Erectile Dysfunction/therapy ; Humans ; Male ; Stem Cell Transplantation/*methods ; Urologic Diseases/*therapy ; Urology/methods/trends

PURPOSE: The development of a new series drugs for treating erectile dysfunction presents the a need for an easy and inexpensive animal experimental models for evaluating the drug effects on penile erectile function. The intracavernous pressure (ICP) is a suitable index for evaluating a penile erection. However, the continuous monitoring of the changes in the penile blood flow volume with an electromagnetic blood flowmeter may provide a new model for measuring the peak penile blood flow volume velocity (PBFVV) as a new index for a penile erection in a rat. MATERIALS AND METHODS: To establish a new suitable index for evaluating a penile erection in rats, measuring both the PBFVV with an electromagnetic blood flowmeter and the ICP with a polygraph were performed and compared. Fifty male adult Sprague-Dawley rats (250 gm) were divided into ICP and PBFVV measurement groups. The rats were anesthetized with 50mg/kg of pentobarbital sodium by an intraperitoneal injection. The left carotid artery was cannulated to measure the systemic blood pressure. Saline or papaverine were injected intracavernously. The ICP was measured with a pressure transducer and a polygraph. The PBFVV was measured after the penile shaft was placed in the ring of a electromagnetic blood flowmeter probe. RESULTS: Both the ICP and peak PBFVV following the intracavernous injection of papaverine were higher compared to both the ICP and peak PBFVV following the saline injection. Both the ICP and PBFVV after an intracavernous papaverine injection increased up to a peak value and then decreased. There was no significant concomitant changes in the systemic blood pressure. CONCLUSIONS: The PBFVV in rats were higher and reflected the veno-occlusive response following the intracavernous papaverine injection as well as the ICP. It is suggested that the peak PBFVV with the electromagnetic blood flowmeter as well as the ICP represents a suitable index for evaluating a penile erection in a rats.
Adult ; Animal Experimentation ; Animals ; Blood Flow Velocity ; Blood Pressure ; Carotid Arteries ; Erectile Dysfunction ; Flowmeters* ; Humans ; Injections, Intraperitoneal ; Magnets* ; Male ; Papaverine ; Penile Erection* ; Pentobarbital ; Rats* ; Rats, Sprague-Dawley ; Transducers, Pressure

PURPOSE: To determine whether the preoperative residual urine fraction(RF) correlates with the change in the maximal flow rate(Qmax) in patients treated for benign prostatic hyperplasia(BPH). MATERIALS AND METHODS: From February 1995 to June 1999, 81 men aged 54 to 82 years (mean: 65.4 +/- 6.7 years) with BPH were examined with Qmax and residual volume using uroflometry and ultrasonography, respectively, before and after transurethral resection of the prostate. The RF was defined as the postvoiding residual/premicturition volume x100. Statistical analysis was performed by simple linear regression using SPSS. RESULTS: The magnitude of improvement in Qmax postoperatively was greatest in patients who had preoperative Qmax < 12mL/sec and RF > 25, followed by Qmax < 12mL/sec and RF < 25, Qmax > 12mL/sec and RF > 25, and Qmax > 12mL/sec and RF < 25. The extent of improvement in Qmax in patients had a value < 12mL/sec was significantly better than that in patients who had a value > 12mL/sec. Among patients who had a Qmax > 12mL/sec preoperatively, the improvement in those who had an RF > 25 was significant better than that in patients who had an RF < 25. CONCLUSION: We suggest that RF and Qmax may have the value as indicator for surgery of benign prostatic hyperplasia preoperatively. The higher RF and Qmax, the poorer postoperative Qmax are anticipates in the patients with benign prostatic hyperplasia.
Humans ; Linear Models ; Male ; Prostate ; Prostatic Hyperplasia* ; Residual Volume ; Transurethral Resection of Prostate* ; Ultrasonography