Objective To evaluate the clinical efficacy and safety of traditional Chinese medicine on internal and external treatment of acne.Methods 128 patients in Dermatology Department of Xiyuan Hospital CACMS from May 2012 to March 2013 were collected and randomly divided into Chinese medicine group and western medicine group.The patients of Chinese medicine group were divided into invasion of the Lung by Wind-Heat syndrome and damp-heat oflmg and stomach syndrome,respectively taking acne liquid 1 or 2 orally and using the herb mask once a week.The western medicine group took Roxithromycin Capsules orally and smeared 0.3％ Viaminate and Vitamin E Cream.The treatment period lasted for 6 weeks,and collected the photograph of the target lesion before and after research every 2 week and evaluated the efficacy.Result The total efficacy rate were 90.77％ (59/65) and 74.60％ (47/63) for Chinese medicine group and western medicine group respectively,with significant difference between them(x2=11.83,P＜0.05).The efficacy rates were 87.50％ and 93.94％ for invasion of the Lung by Wind-Heat syndrome and damp-heat of lung and stomach syndrome respectively,with no significant difference between them(x2=0.416,P＞0.05).The TCM symptom scores after treatment [Chinese medicine group (4.36 ± 2.45),western medicine group (8.62± 2.49)] had significant difference in two groups respectively compared with before treatment[Chinese medicine group(15.33±6.08),western medicine group(14.34±5.29),P＜0.05].The difference of TCM symptom scores after treatment between the two groups also had a significant difference (P＜0.05).The TCM symptom scores after treatment of invasion of the Lung by Wind-Heat syndrome group and damp-heat of lung and stomach syndrome group were (4.50±3.01) and (4.24±1.83),which had a significant difference compared with before treatment respectively[(15.37±7.03)and(15.29±5.13),P＜0.05].Conclusion The TCM internal and external treatment on acne could reduce the number of lesions and improve TCM symptom scores.The effect of treating invasion of the Lung by Wind-Heat syndrome and damp-heat of lung and stomach syndrome with TCM was almost equal.

To investigate the clinical characteristics and angio-architecture features of patients with dural arteriovenous fistulas (DAVF).The clinical data of 48 patients with DAVF were analyzed retrospectively.All patients were diagnosed by digital subtract angiography and 43 cases were also examined by MRI.Patients were divided into the bleeding group and non-bleeding group,whose clinical features and angio-architecture were compared.Of 48 cases,13 patients demonstrated intracranial bleeding,and men were more common in bleeding group (M/F:10/3) than in non-bleeding group (M/F:15/20) (P =0.036).The Cognard scores of bleeding group and nou-bleeding group were 3.77 ±0.28 and 2.49 ±0.21,respectively (P =0.002) ; however,there was no significant difference in age and the number of feeding artery between two groups.The results indicate that male patients with high Cognard scores tend to intracranial bleeding.

Objective To investigate the effects of magnesium isoglycyrrhizinate on liver function of patients with gastrointestinal cancer following chemotherapy.Methods From Apr.2012 to Dec.2015,a total of 168 cases of patients with gastrointestinal cancer following chemotherapy were enrolled,and were randomly divided into observation group(84 cases) and control group(84 cases).Each of the two groups was divided into A group(42 cases) and B group(42 cases) according to the treatment methods.Patients of observation group(including observation A group and observation B group) were treated with magnesium isoglycyrrhizinate,while patients of control group(including control A group and control B group) were treated with glutathione.Patients of A group(including observation A group and control A group) were treated with FOLFOX4 regimen,while patients of B group(including observation B group and control B group) were treated with XELOX regimen.The incidence of abnormal liver function and changes of the levels of liver function of each group were analyzed and compared.Results After the appropriate treatment,the abnormal rate of liver function of observation group were significantly lower than control group(P<0.05).After treatment,levels of liver function parameters in observation group and control group were all significantly increased(P<0.05),and those in control group were higher than observation group(P<0.05).After treatment,levels of liver function parameters in observation A group and control A group were all significantly increased(P<0.05),and those in control A group were higher than observation A group(P<0.05).After treatment,levels of liver function parameters in observation B group and control B group were all significantly increased(P<0.05),and those in control B group were higher than observation B group(P<0.05).Conclusion Magnesium isoglycyrrhizinate could be with protection effects on liver function of patients with gastrointestinal cancer following chemotherapy,which might be worthy of promotion.

0.05).2.Two days after treatment,total protein(TP) and albumin(Alb) of hemotoplasma were significantly higher than before treatment(all P0.05).3.Toxic side effects: gastrointestinal reaction was seen in 20 cases ((52.63%)),reduction of WBC in 2 cases(5.26%),baldness in 38 cases(100%) and heart impairment in 1 case(2.63%).The sperm test and menstrual onset were normal in 18 cases,whose ages ≥ 8 years at beginning of treatment,who were clinically cured and whose ages ≥17 years at the time of last following up,7 of them who had married could have children.Conclusions Combining CTX(conti-)(nuous) stosstherapy with prednisone standard scheme treated the children in Zhuang nationality with NS,We could got a good curative effect.By using this treatment,not only the plasma TP and Alb level could be increased rapidly and the urine protein could be conversed to negative quickly.The accumulated amount of CTX was less than 80 mg/kg,but the treatment was safety in the recent term, and no impairment of sexual gland was seen at long-term following up.

Objective To explore the effect of music intervention on the depression mental of postoperative chemotherapy interval patients with breast cancer.Methods Totals of 60 breast cancer patients in post-operative chemotherapy interval were selected and were randomly divided into control group and intervention group.Control group patients received routine nursing and intervention group received music intervention based on routine nursing care,before and after intervention,all patients were investigated with depression self-rating scale(SDS) and the effect of music intervention was analysed.Results There was no difference about depression incidence and score of SDS in two groups before intervention ( P ＞ 0.05 ).After intervention,the ration of depression was 23.33％ and the score of SDS was ( 35.60 ± 5.62) in intervention group,lower than control group,which depression ration was 83.33％,and SDS score was(42.87 ±6.34),and the difference was statistically significant (x2=21.90,t=-3.8 ;P ＜ 0.01 ).No difference was found in control group about the score of SDS before and after intervention ( P ＞ 0.05 ),while significantly difference was found in intervention group ( t=- 8.3,P ＜ 0.01 ).Conclusions Music intervention can significantly improve depression mental of post-operative chemotherapy interval patients with breast cancer.

OBJECTIVETo investigate the pulmonary function after treatment in neonates with respiratory distress syndrome (RDS) at varying disease severity levels and different gestational ages.

METHODSA total of 107 neonates with RDS were divided into <34 weeks group (65 neonates), late preterm group (21 neonates), full-term group (21 neonates). Another 121 non-RDS children were enrolled as the control group. According to the severity of RDS, the RDS neonates were divided into mild RDS group (grades 1 and 2; 76 neonates), and severe RDS (grades 3 and 4; 21 neonates). The tidal breathing pulmonary function was measured at a corrected gestational age of 44weeks.

RESULTSThe pulmonary function parameters showed no significant differences across the groups of RDS neonates of different gestational ages; the tidal volume per kilogram of body weight (VT/kg) showed no significant difference between the RDS and non-RDS groups, while the RDS group had significantly higher ratio of time to peak tidal expiratory flow to total expiratory time (tPTEF/tE) and ratio of volume to peak tidal expiratory flow to total expiratory volume (vPTEF/vE) than the non-RDS group of the same gestational age (P<0.05). At a corrected gestational age of 44 weeks, the two groups of neonates with varying severity levels of RDS had significantly lower tPTEF/tE and vPTEF/vE than the control group (P<0.05), and tPTEF/tE and vPTEF/vE tended to decrease with the increasing severity level of RDS.

CONCLUSIONSNeonates with RDS have significantly decreased pulmonary function than those without RDS. At a corrected gestational age of 44 weeks, the tidal breathing pulmonary function in neonates with RDS is not associated with gestational age, but is associated with the severity of RDS.

Female ; Gestational Age ; Humans ; Infant, Newborn ; Lung ; physiopathology ; Male ; Respiratory Distress Syndrome, Newborn ; physiopathology

Brain ; N-Methylaspartate ; Neurons ; Patch-Clamp Techniques

OBJECTIVEThe several species of the genus Paris called as Rhizoma Paridis were famous traditional Chinese medica. To develop the quantitative analysis method of the steroidal saponins in some species of the genus Paris and commercially available Rhizoma Paridis samples by HPLC-ELSD.

METHODThe contents of 11 steroidal saponins in Rhizoma Paridis samples were dectected with a Kromasil C18(4.6 mm x 150 mm, 5 microm) column which was deluted with acetonitrile-water (30:70-60:40) at a flow rate of 1 mL x min(-1) by HPLC-ELSD.

RESULTAll the authentic samples could be separated and calibration curves of 11 saponins were prepared. 11 steroidal saponins in 16 Rhizoma Paridis samples were detected in 30 min. The recovery for the assay of saponins was between 95% and 97%. The precision and stability of samples (RSD) were below 3%.

CONCLUSIONThe method was shown to be accurate and convenient, and suitable for the quantitative analysis of these 11 steroidal saponins in the commercially available Rhizoma Paridis samples.

Chromatography, High Pressure Liquid ; Liliaceae ; chemistry ; Molecular Structure ; Plants, Medicinal ; chemistry ; Rhizome ; chemistry ; Saponins ; analysis ; chemistry ; Spectrometry, Mass, Electrospray Ionization

Glutamate is not only the major excitatory neurotransmitter in the central nervous system of human and mammalian animals but also participates the synaptic transmission of peripheral sensory system.How-ever, overstimulation of glutamate receptors by excessive glutamate leads to glutamate excitotoxicity.This review discusses the neurotransmission of glutamate in the vestibular end organs and the excitotoxicity by glutamate on them in motion sickness as well as the antimotion sickness drugs asso-ciated with glutamate neurotransmission.

Objective To study the effect of traditional Chinese medicine (TCM) five elements music on cancer-related fatigue CRF of chemotherapy patients.Methods 80 patients were randomly divided into the experimental group and the control group equally.The experimental group was given the TCM five elements music intervention on the basis of routine care at the start of chemotherapy for 60 min,once a day for three cycles,each cycle and chemotherapy cycle were synchronic.The control group was given routine care with emphasis on psychological care.The two groups were given the CRF assessment of Brief Fatigue Inventory developed by the pain research team of the U.S.Adorson Cancer Center before and after the treatment,and the quality of life of patients was evaluated by Quality of Life Questionnaire (EORTC-QLQ-C30) by the European Cancer Treatment and Research Organization.Results CRF levels of the experimental group were markedly reduced after the intervention of TCM five elements music,among which slight fatigue accounted for 37.5％,moderate fatigue accounted for 10％ and serious fatigue accounted for 2.5％.There was significant difference between the two groups ( U =6.062 3,P ＜ 0.0 1 ).The proportion of moderate and serious fatigue was 12.5％ in the experimental group and 40％ in the control group after treatment,and there was significant difference between the two groups (U=3.282 8,P＜0.01 ).The total score of quality of life was (43.12±6.21) in the experimental group and (52.30 ± 7.28 ) in the control group after treatment.The difference was statistically significant (t =4.683 0,P＜0.05).Conclusions Application of TCM Five Elements music intervention on chemotherapy patients can eliminate or alleviate CRF and improve the quality of life of patients.