OBJECTIVETo study the releasing rate of chrysophanol from Ruyi Jinhuang plaster.

METHODBased on the detecting methods of releasing rate and residual dosage applied in (Pharmacopoeia of P. R. C) (2000 edition), the contents of chrysophanol were detected by HPLC.

RESULTChrysophanol in Ruyi Jinhuang plaster could well be released from plaster and to form medicinal concentration gradient.

CONCLUSIONChrysophanol in Ruyi-Jinhuang plaster can possibly be absorbed by skin.

Administration, Cutaneous ; Animals ; Anthraquinones ; metabolism ; Curcuma ; chemistry ; Drug Combinations ; Drugs, Chinese Herbal ; isolation & purification ; pharmacokinetics ; Female ; Guinea Pigs ; Male ; Phellodendron ; chemistry ; Plants, Medicinal ; chemistry ; Rheum ; chemistry ; Skin ; metabolism ; Skin Absorption

Diabetic nephropathy (DN) is one of the most common and serious microvascular complications in patients with diabetes mellitus. Diabetic renal fibrosis ( DRF) is a major pathological change in the development of DN. In recent years the incidence of renal fibrosis (RF) has remained high. For diabetic patients, RF may expose them to kidney transplantation or even death, which brings a great burden to themselves and their families. Therefore, learning the pathogenesis and the current treat ment status of DRF is crucial for the treatment of the disease and the development of new drugs. Here we review the general situa¬tion of DN, the general situation, molecular mechanism, and the treatment of DRF,looking forward to providing a reference for the research and treatment of DRF.