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Forty eight skin biopsies obtained from 24 patients were reviewed, and clinical, histological and immunohistochemical findings were analyzed. Results obtained are as follows: 1) Skin manifestation was plaque, erythroderma, scale and hyperpigmentation in mycosis fungoides, and subcutaneous nodule, mass and ulcerated patch in cutaneous lymphoma. The skin of lymphomatoid papulosis revealed hemorrhagic ulcerated and erythematous papules which healed spontaneously. 2) Histologically, mycosis fungoides showed epidermotropism in most cases. Pautrier's micro-abscesses were present in one-fourth of the cases. Malignant lymphoma was different in histology from mycosis fungoides. As compared with mycosis fungoides, it showed less frequent epidermotropism, more compact and diffuse infiltration of atypical lymphocytes, more often association with ulcer and necrosis, and more frequent mitotic figures. Lymphomatoid papulosis showed striking hemorrhage and edema of the papillary dermis. 3) Based on the results of immunohistochemical study, mycosis fungoides and lymphomatoid papulosis were considered as a T cell proliferative disorder of the skin. According to these findings, lymphoproliferative disorders of the skin occurred predominantly in the elderly and males. Clinical and histopathologic findings overlapped and were similar each other. It was difficult to make a definite diagnosis in early lesions, and a sequential follow up biopsy was required. It is concluded that strict criteria such as marked atypia and clustering of atypical cells are necessary for a histologic diagnosis of malignant lymphoproliferative disorder of the skin.
Biopsy

1.Two Cases of Anomalous Origin of the Right Pulmonary artery from the Ascending Aorta.

2.Prognosis of Complete Transposition on the great Arteries.

3.Clinical Observation on Amiodarone Treatment for Critical Arrhythmia in Children.

4.A Case of Anomalous Origin of the Left Coronary Artery from the Pulmonary Artery.

5.A Pathologic Study of Lymphoproliferative Disorders of the Skin.

6.Studies on Arrhythmias in School Children.

7.Study on Diagnostic Methods for Spleen in Complex Heart Disease.

8.Heart Disease Screening for Primary School Children.

9.Cardiac Involvement of Kawasaki Disease.

10.Clinical Observation of Truncus Arteriosus.

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