The S100 proteins are a multi-gene calcium-binding family,which are differently expressed in a variety of tumors.It is found to be associated with tumor invasion and metastasis.As a tumor-associated biomarkers,unraveling the relationship between S100 and prostate cancer progression as well as molecular mechanisms,would provide an important basis for the clinical diagnosis and therapeutic monitoring.

Ca2+signaling is fundamental for information process-ing in the peripheral nervous system,which regulates a variety of physiological activities.Ca2+signaling and calcium homeostasis are directly associated with neuropathology.Recently,studies on Ca2+signaling contribute to a deeper comprehension of the path-ogenesis of diabetic peripheral neuropathies,which provide a new research direction for the treatment of diabetic peripheralneuropathies.This review aims to highlight the relationship be-tween calcium signaling,sensory neurones and neuroglial cells in the context of diabetic peripheral neuropathies.

Objective The aim of this prospective randomized study was to compare the effects of remifentanil (R) and fentanyl (F) given by target-controlled infusion (TCI) on the Cp50 of TCI propofol for loss of consciousness ( LOC ) . Methods Sixty-four ASA 1 or II patients aged 20-55 yr undergoing elective cholecystectomy or mastectomy under general anesthesia were enrolled in this study. Their BMI ranged from 18-30 kg?m-2. The patients were randomly allocated to one of four groups with 16 patients in each group: (1) propofol alone (P), (2) P + remifentanil (Cp = 4 ?g?L-1 ) (R4), (3) P + remifentanil (Cp = 7 ?g?L 1 ) (R7) and (4) P + fentanyl (Cp = 4?g?L-1 ) (F). The patients were unpremeditated. Anesthesia was induced with remifentanil or fentanyl and propofol both given by TCI. The plasma concentration (Cp) of remifentanil and fentanyl were fixed in each group. The Cp50 of propofol for LOC was determined by up-and-down sequential trial. Cp of propofol was set at 1.25, 1.50, 1.80, 2.16, 2.59, 3.11, 3.73 and 4.48 mg?L-1 . If a patient did not go to sleep at a certain Cp of propofol, the next patient was tested at a higher concentration conversely if the patient went to sleep a lower concentration was tested in the next patient. The BIS values and hemodynamic changes were recorded before induction and at LOC (no response to verbal command and loss of eyelash reflex). The TCI pump was controlled by pharmacokinetic models developed by Marsh (propofol) Minto ( remifentanil) and Shafer ( fentanyl) . Results The Cp of propofol for LOC in group P was 3.48 mg ? L-1 , significandy higher than that in group F (2.31 mg ? L -1 ), group R4 (2.11 mg?L-1) and group R7 (1.76mg?L-1 ) (P

Biomarkers ; Disease Susceptibility ; Humans ; Pneumoconiosis ; etiology

Humans ; Polymorphism, Genetic ; Pulmonary Fibrosis ; genetics ; physiopathology ; Transforming Growth Factor beta ; genetics ; physiology

Animals ; Humans ; Interleukin-1 ; physiology ; Mice ; Pulmonary Fibrosis ; physiopathology ; Rats ; Receptors, Interleukin-1 ; physiology

Totally 896 medical records were statistically analyzed from Jan. 1, ] 998 to Dec. 31 , 2001. There were 65 cases (7. 3%,65/896) of ischemic cardiomyopathy .of which 38 cases (58. 5% .38/65) were myocardial infarction in small area, 27 cases(41. 5% ,27/65) were in large area. The causes of ischemic cardiomyopathy were lack of blood supply in cardiac cells for a long time and pathological changes in branches of coronary artery. If myocardial infarction in small area occurred,the blood vessels should be opened again in acute period, and the risk factors must be prevented and treated.

Animals ; Humans ; Interleukin-6 ; physiology ; Liver Cirrhosis ; physiopathology ; Mice ; Pulmonary Fibrosis ; physiopathology ; Rats

To study the function and mechanism of the NgR-Rhoa- Rock signal pathways which exists in the retinal ganglion cells apoptosis in diabetes mellitus (DM) rats.
● METHODS: Some healthy SD rats were operated by means of single intraperitoneal injection of 1%streptozotocin based on the standard of 50mg/ kg wight, after that the blood sugar value was greater than 16. 7mmol/ L as DM model, then randomly divided into 3 groups, each group was 10 rats. ln addition to take 10 healthy SD rats as control group. Four groups of rats were bilaterally eyeball intravitreal injection in turn with NgR-siRNA virus 10μ L (siRNA group), NgR-siRNA virus diluted 10μ L ( DM group), NgR - siRNA virus - negative -control solution 10μ L (siRNA blank group), NgR- siRNA virus diluted 10μ L ( normal control group ), and fed normally. During that time, some life indexes like blood glucose, body mass, etc. were measured and recorded. After 12wk, the expression of NgR and Rhoa, HE staining, and TUNNEL staining were detected by Western blot analysis.
● RESULTS: Western blot analysis: compared with normal control group, the expression of NgR and Rhoa in DM group and siRNA blank group increased significantly (P<0. 01), while siRNA group was no significant change (P > 0. 05); compared with DM group and siRNA blank group, the expression of those proteins significantly lowered in siRNA group. HE staining: compared with normal control group, some extent ganglion cells arranged disorder, irregular shape, spacing not consistent were all found in three groups of model rats;compared with DM group and siRNA blank group, there was some improvement in siRNA group of ganglion cells about the order and shape size. TUNEL staining:compared with normal control group, there were retinal ganglion cells apoptosis in all of three groups of model rats. Compared with DM group and siRNA blank group, the number of retinal ganglion cells apoptotic cells was less, and the shape of cells had improved significantly in siRNA group.
●CONCLUSlON: ln the DM phase, the expression of NgR and Rhoa were up - regulation, the condition of diabetic retinal ganglion cell apoptosis was improved after that the NgR-Rhoa-Rock signal pathways had been inhibited.