No Abstract Available.
Hepacivirus* ; Hepatitis C* ; Hepatitis*

Angiogenesis depends on the net balance between positive and negative angiogenic factors. Tumor cells are angiogenic resulting from increased production of positive factors and decreased production of negative factors. Among these, vascular endothelial growth factor and glioma- derived angiogenesis inhibiting factor are related to glioblastoma multiforme. The p53 gene is more frequently mutated than any other known oncogene or tumor suppressor gene in human tumors including glioblastoma multiforme. Angiogenesis is reported to be controlled by p53 regulation in recent studies. To examine the effect of p53 overexpression on angiogenesis in glioblastoma multiforme, we performed immunohistochemical staining in 51 cases of glioblastoma multiforme, using monoclonal antibodies to p53 protein and factor VIII. 20 cases of low grade astrocytoma were used as control. p53 overexpression was present in 15(75%) of 20 cases of low grade astrocytoma and the mean vessel count was 37.7+/-9.9 at x200 field and 17.5+/-5.8 at x400 field. p53 overexpression was present in 35(68%) of 51 cases of glioblastoma multiforme and the mean vessel count was 91.9 45.8 at x200 field and 40.7 19.1 at x400 field. Mean vessel count in low grade astrocytoma with p53 overexpression was 39.4 10.2 at x200 field and 18.9 5.7 at x400 field, while in cases without p53 overexpression it was 32.4+/-7.6 at x200 field and 13.2 3.5 at x400 field. Mean vessel count in glioblastoma multiforme with p53 overexpression was 94.5+/-51.8 at x200 field and 42.1+/-16.8 at x400 field, while in cases without p53 overexpression it was 86.1+/-29.5 at x200 field and 37.1+/-16.8 at x400 field. The mean survival time was 12.4 months in the 39 cases of glioblastoma multiforme in which follow-up studies were possible. Significant prognostic factors were age, p53 overexpression and adjuvant therapy. These results show that p53 gene mutation is one of the many contributing factors to angiogenesis in glioblastoma multiforme. In addition, other oncogenes and tumor suppressor genes, as well as growth factors may be involved. Age, p53 overexpression and adjuvant therapy proved to be significant prognostic factors, while microvessel density was not.
Angiogenesis Inducing Agents ; Antibodies, Monoclonal ; Astrocytoma ; Brain Neoplasms* ; Brain* ; Factor VIII ; Follow-Up Studies ; Genes, p53* ; Genes, Tumor Suppressor ; Glioblastoma ; Humans ; Intercellular Signaling Peptides and Proteins ; Microvessels ; Oncogenes ; Survival Rate ; Vascular Endothelial Growth Factor A

No abstract available.
Emergencies* ; Emergency Service, Hospital* ; Humans ; Statistics as Topic*

No abstract available.

No abstract available.

No abstract available.
Lipodystrophy*

PURPOSE: TThe purpose of this retrospective study was to demonstrate the characteristic findings of ultrasonogram and the functional result in the surgical excision of the interdigital neuroma. MATERIALS AND METHODS: Forty feet of thirty-five patients with clinical sign and symptoms of interdigital neuromas were examined by ultrasound with a 7.5MHz transducer, In 23 of these patients, surgical excision and pathological analysis of their interdigital masses were subsequently performed. RESULTS: Interdigital neuromas were seen sonographically as well-defined, ovoid, hypoechoic masses located just proximal to the metatarsal heads in the intermetatarsal space. The diameter of neuroma on average was 5.6 mm in the 2nd interspace, 5.4 mm in the 3rd and 4 mm in the 1st. Postoperatively, the satisfactory result was exellent in five (22%), good in twelve (52%), fair in four (17%) and poor in two (9%). CONCLUSIONS: These results suggest that ultrasonographic examination is an accurate diagnostic technique, and surgical excision is most effective method of treatment in the view of pain management than other therapeutic modalities in patients with clinically suspected interdigital neuroma.
Diagnosis* ; Foot ; Head ; Humans ; Metatarsal Bones ; Neuroma* ; Pain Management ; Retrospective Studies ; Transducers ; Ultrasonography

No abstract available.
Family Practice* ; Follow-Up Studies* ; Humans ; Internship and Residency*

No abstract available.
Aeromonas* ; Enterotoxins*

No abstract available.
Animals* ; Escherichia coli* ; Escherichia* ; Humans*