1.A statistical analysis of methicillin-resistant staphylococcus aureus.
Yong Woon PAIK ; Ji Suk KIM ; Yun Joo CHEUNG ; Suk Ja PARK ; Hung KIM
Journal of the Korean Pediatric Society 1991;34(5):645-653
No abstract available.
Methicillin Resistance*
;
Methicillin-Resistant Staphylococcus aureus*
2.Effects of Reactive Oxygen Metabolite on the Calcium Transport of Cardiac Mitochondria.
Myung Suk KIM ; Yun Song LEE ; Seok Chan HONG
Korean Circulation Journal 1994;24(1):145-155
BACKGROUND: Intracellular calcium overload is a common final feature of the ischemic-reperfused heart and mediates the genesis of irreversible cell damage. Reactive oxygen medabolites have been known to play and important role as toxic mediators in myocardial injuries resulting from ischemia and reperfusion. In order to investigate the mechanism of intracellular calcium accumulation in the ischemic-reperfused myocardium, the present study observed the possible contribution of the reactive oxygen metabolite to the calcium transport of cardiac mitochondria. METHODS: Mitochondrial were isolated from rabbit hearts. The effects of a reactive oxygen metabolite, H2O2 on calcium uptake and release, redox states of endogenous pyridine nucleotides and glutathiones of mitochondria respiring with succinate were observed. Calcium uptake and release were monitored by dual-wave length spectrophotometer using a calcium indicator, arsenaze III. Contents and redox states of pyridine nucleotides and glutathiones were measured by enzymatic methods using spectrofluorometer and HPLC. RESULTS: Hydrogen peroxide(10-500microM) promoted calcium release dose-dependently from CA++-preloaded mitochondria, but did not affect the mitochondrial calcium uptake. The H2O2-induced calcium release was accompanied by simultaneous oxidation of the pyridine nucleotides and decrease in the content of the reduced form of glutathione(GSH). When mitochondria were treated with BCNU(N,N=bis(2-chloroethyl)-N-nitrosourea) to inhibit glutathione reductase and so as to reduce the GSH content, there were no increase in calcium release from the mitochondria. These results may indicate that H2O2 increases the permeability of cardiac mitochondrial membrane to calcium in association with the changes in redox state of endogenous pyridine nucleotides, but not with that of glutathiones. CONCLUSION: It is suggested that the reactive oxygen metabolites induce the release of calcium from mitochondria by altering the redox state of pyridine nucleotides, and it may partly be involved in the elevation of cytosolic calcium concentration in the ischemic-reperfused myocardial cells.
Calcium*
;
Chromatography, High Pressure Liquid
;
Cytosol
;
Glutathione Reductase
;
Heart
;
Hydrogen
;
Ischemia
;
Mitochondria*
;
Mitochondrial Membranes
;
Myocardium
;
Nucleotides
;
Oxidation-Reduction
;
Oxygen*
;
Permeability
;
Reperfusion
;
Succinic Acid
3.Arterio-venous malformation in the chest wall: a case report.
Yun Young CHOI ; Kyo Nam KIM ; Heung Suk SEO
Journal of the Korean Radiological Society 1991;27(6):796-798
No abstract available.
Thoracic Wall*
;
Thorax*
4.Videothoracoscopic excision of mediastinal tumor: two cases report.
Doo Yun LEE ; Hae Kyoon KIM ; Dong Suk MOON
The Korean Journal of Thoracic and Cardiovascular Surgery 1992;25(7):723-726
No abstract available.
5.Closure of post left pneumonectomy bronchopleural fistula with emphysema thoracis(transsternal transpericardial approach): one case report.
Dong Suk MOON ; Doo Yun LEE ; Hae Kyoon KIM
The Korean Journal of Thoracic and Cardiovascular Surgery 1992;25(6):593-597
No abstract available.
Emphysema*
;
Fistula*
;
Pneumonectomy*
6.Production of Superoxide Anion and Damage of Mitochondria Isolated from Ischemic Repertused Heart.
Chong Yun RIM ; Young LEE ; Yun Song LEE ; Myung Suk KIM
Korean Circulation Journal 1991;21(6):1137-1151
BACKGROUND: Oxygen free radicals have been implicated as a cause of deleterious effects in the setting of coronary reperfusion, and they are believed to be generated by the xanthine oxidase system, from activated neutrophiles and from mitochondria. We evaluate the contribution of mitochondria to the production of oxygen free radicals and clarify the mechanism of cellular damage in ischemic reperfused hearts. METHODS: Mitochondria isolated from the ischemic rabbit hearts were incubated in the reaction conditions with different oxygen tensions. Generation of superoxide anion and activities of defensive enzymes aginst oxidative stress were mesured. RESULTS: Superoxide anion genertion by mitochondria incubated in 21% oxygen condition were 0.54+/-0.09 and 0.27+/-0.04(O2./min/mg protein) in ischemic mitochondria and in control respectively(P<0.05). Activites of defensive enzymes against oxidative stress, superoxide dismutase and glutathione peroxidase, were significantly reduced in mitochondria isolated from either ischemic or reperfused hearts. With the lapse of respiration in 21% oxygen condition, ADP-stimulated state 3 oxygen consumption(306.4+/-31.5 vs 214.4+/-11.4n atoms O/min/mg protein) at 30 minutes, P : O ratio and phosphorylation rate were significantly decreased in ischemic mitochondria. CONCLUSION: Elevation of oxygen free radical generation as well as the reduction of defensive enzyme activities in ischemic reperfused mitochondria are injurious to mitochondrial respiratory function. It may contribute to the mechanism of cellular damage in ischemic reperfused hearts.
Free Radicals
;
Glutathione Peroxidase
;
Heart*
;
Mitochondria*
;
Myocardial Reperfusion
;
Neutrophils
;
Oxidative Stress
;
Oxygen
;
Phosphorylation
;
Respiration
;
Superoxide Dismutase
;
Superoxides*
;
Xanthine Oxidase
7.Surgical treatment of stage III carcinoma of the lung afterpreoperative chemotherapy and radiation therapy: 8 cases report.
Doo Yun LEE ; Suk Joong JOO ; Hae Kyun KIM ; Sang Jin KIM ; Hyung Joong KIM
The Korean Journal of Thoracic and Cardiovascular Surgery 1992;25(9):962-967
No abstract available.
Drug Therapy*
;
Lung*
8.Thoracic outlet syndrome: one case report.
Hong Suk KIM ; Doo Yun LEE ; Hae Kyoon KIM ; Ki Man BAE
The Korean Journal of Thoracic and Cardiovascular Surgery 1991;24(12):1192-1196
No abstract available.
Thoracic Outlet Syndrome*
9.Open lung biopsy for diffuse infilterative lung disease.
Hae Kyoon KIM ; Doo Yun LEE ; Sung Nok HONG ; Hong Suk KIM
The Korean Journal of Thoracic and Cardiovascular Surgery 1991;24(9):903-906
No abstract available.
Biopsy*
;
Lung Diseases*
;
Lung*
10.Outcome of Surgical Angioplasty for Isolated Coronary Ostial Stenosis.
Keon Sik MOON ; Yun Joong KIM ; Jae Sung KIM ; Suk Keun HONG ; Hweung Kon HWANG
Korean Circulation Journal 1999;29(1):46-54
BACKGROUND: Although surgical angioplasty for isolated coronary ostial stenosis is assumend as an alternative approach to CABG, the clinical features of isolated coronary ostial stenosis, postoperative complications and follow-up angiographic results would have not been well studied. METHODS: We retrospectively studied 24 patients (female : male = 20 : 4, mean age 50.0 +/- 12.3 yr) who underwent surgical angioplasty for isolated coronary ostial stenosis using patch ( 22 fresh autologous pericardium, 2 saphenous vein) during the period of March 1990 through February 1998. Repeat coronary angiography (16 patients) and echocardiography (24 patients) were performed. Aortic regurgitation was evaluated semiquantitatively (Grade I - Grade IV). RESULTS: There were 3 deaths after surgical angioplasty. One death was due to acute coronary dissection perioperatively, the second due to low cardiac output syndrome 2 weeks post-surgery, and the third due to traumatic panperitonitis 10 months post-procedure. Angina recurred in 4 patients and the remaning 18 patients were symptom-free. Repeat angiography (19.3 +/- 20.7 Mo) showed widely patent ostium with excellent run-off except 2 patients (1 distal patch stenosis, 1 ostial restenosis in Takayasu's arteritis). The third symptomatic patient was proven to have coronary spasm by ergonovine test. AR increased in the fourth patient (Grade II -> III) with patent ostium. CONCLUSION: Surgical angioplasty may be feasible and alternative operative method to CABG for isolated coronary ostial stenosis. It should however be noted that postop AR can develop and/or increase. Further investigation is needed to evaluate the clinical significance of the AR.
Angiography
;
Angioplasty*
;
Aortic Valve Insufficiency
;
Cardiac Output, Low
;
Constriction, Pathologic*
;
Coronary Angiography
;
Coronary Artery Disease
;
Echocardiography
;
Ergonovine
;
Follow-Up Studies
;
Humans
;
Male
;
Pericardium
;
Postoperative Complications
;
Retrospective Studies
;
Spasm