No abstract available.
Anemia, Hemolytic* ; Child* ; Humans

Responses of mouse lymphocytes to the soybean paste fermented by Korean traditional fashion was examined to clarify its effects in cytokine production in vitro. A fraction of the soybean paste (KFSP-100) was prepared by precipitation with ammonium sulfate and by filtration through ultrafiltration membrane. KFSP-100 were added into cultures of fresh mouse splenic cells in vitro. KFSP-100 significantly enhanced the amount of IL-6 and TNF-a produced by macrophages and IL-6 and IFN-r produced by lymphocytes. Production of IL-12 by macrophages was not much affected by KFSP-100 treatments. The most noticeable finding was the fact that lymphocytes treated with KFSP-100 proliferated to an exceeding numbers (more than 10 times to the control) in 72 hours. The KFSP-100-induced proliferative response was specific to B cells since almost all of the KFSP-100-induced cells in the cultures of splenic cells were B cells. Furthermore, such a proliferative responses were equally observed only in cultures of purified B cells but not in cultures of T cells. In thermostability test, the biologically active components of the KFSP-100 is assumed to be either linear protein or glycoprotein. KFSP-100 did not induce agglutination of lymphocytes demonstrated by lectins in the same cells. These observations suggest that KFSP-100 may be a novel mitogen for B lymphocytes. The component (s) responsible for the B cell proliferation in KFSP-100 might be a factor gained by natural fermentation. None of the fractions of not fermented soybean paste prepared by the same methods demonstrate the same effect.
Agglutination ; Ammonium Sulfate ; Animals ; B-Lymphocytes ; Cell Proliferation ; Fermentation ; Filtration ; Glycoproteins ; Immunologic Factors* ; Interleukin-12 ; Interleukin-6 ; Lectins ; Lymphocytes ; Macrophages ; Membranes ; Mice ; Soybeans* ; T-Lymphocytes ; Ultrafiltration

Pancreatic pseudocyst occurs as a complication of pancreatitis or trauma, which results in the escape of pancreatic enzymes from the parenchyma or ductal system of pancreas. At that time, serum amylase may have returned to normal level, and the patient may be subjectively asymptomatic. In this phase, the radiologic findings are relatively greater significance than laboratory data. In the conventional radiologic study, pancreatic pseudocyst have been frequently confused with other retroperitoneal mass, but recently with clinical application of ultrasound and CT scan, more accurate diagnosis can be obtained. The brief results are as follows; 1. Male to female ratio was 3:2 in 15 patients. Incidence was most common in young adult age. Most frequent symptom was epigastic pain, and which was noted in 11 cases of patients. 7 cases of patients had past history of abdominal trauma and past history of pancreatitis was only in 1 case. Most common laboratory finding was leukocytosis in 8cases of patients and elevated serum amylase was also noted in 7 cases. 2. In each 5 cases of patients, plain chest roentgenologic evidence of left side pleural effusion and hemidiaphragm elevation were observed. 3. On flat abdomen film, soft mass shadow was visualized in 8 cases of patients. On UGI series, evidence of retrogastric space widening was observed in 11 cases of patients. 4. The location of pseudocyst is mainly in body and tail of pancrease in 11 cases of patients. 5. More accruable diagnosis can be obtained through application of ultrasound and CT scan.
Abdomen ; Amylases ; Diagnosis ; Female ; Humans ; Incidence ; Leukocytosis ; Male ; Pancreas ; Pancreatic Pseudocyst ; Pancreatitis ; Pancrelipase ; Pleural Effusion ; Tail ; Thorax ; Tomography, X-Ray Computed ; Ultrasonography ; United Nations ; Young Adult

We have experienced a case of tuberculous abscess of the liver with empyema in a 12 years old boy. He was admitted with the chief complaints of pain and mass in the right upper abdomen of about 1 month duration and intermittent mild fever for 15 days. On examination, liver was palpable 5 cm below the right costal margin, and was tender and firm. Liver scan showed a cold area in the right posterior upper part of the liver. With the needle aspiration of the liver, 240 ml of yellowish-green pus was aspirated. The stained smears of the pus showed a large number of acid-fast bacilli, and the culture revealed a growth of Mycobacterium tuberculosis. Our patient was cured successfully by the drainage of pus with the needle aspiration of the liver and antituberculous medication. We have presented here a rare case whose the diagnosis was made without the help of any operative procedure, and reviewed the literatures.
Abdomen ; Abscess* ; Child ; Diagnosis ; Drainage ; Empyema* ; Fever ; Humans ; Liver* ; Male ; Mycobacterium tuberculosis ; Needles ; Suppuration ; Surgical Procedures, Operative

We report a case of gastroenteritis due to Yersinia enterocolitica in a 7month old male infant who was misdiagnosed as shigellosis at onset of illness. He was treated with Gentamicin successfully. A marked improvement was resulted in clinical symptoms and laboratory finding at the time of discharge. It is a second case of Y.enterocolitica which is proved by stool culture in Korea.
Dysentery, Bacillary* ; Enteritis* ; Gastroenteritis ; Gentamicins ; Humans ; Infant ; Korea ; Male ; Shigella ; Yersinia enterocolitica

Moyamoya disease is characterised by stenosis or occlusion in the distal portions of the internal carotid artery. There is the associated finding of a fine network of abnormal vessels ('moyamoya' vessels, that is 'puff of smoke' like appearance) in the region of the basal ganglia. We experienced two cases of moyamoya disease which was confirmed by carotid angiogram. Case 1 had complaints of speech disturbance and clonic movement of right leg. Case 2 had been suffered from transitory repetitive paroxysmal hemiplegia. Review of literatures and references on moyamoya disease was done briefly.
Basal Ganglia ; Carotid Artery, Internal ; Constriction, Pathologic ; Hemiplegia ; Leg ; Moyamoya Disease*

Spina bifida or cranium bifidum result from a failure in fusion of skull(cranium bifidum) or the vertebral column(spina bifida). These entities are the most common anomalies of the nervous system which are associated with major abnormalities of cellular migration, and secondary mechanical deformities of the nervous system. During the last 12 years from Jan. 1967 to Dec. 1978, 83 cases of spina bifida and cranium bifidum had been admitted to the department of Pediatrics, Severance Hospital and evaluated clinically. Literature review were also made birefly.
Congenital Abnormalities ; Encephalocele* ; Nervous System ; Pediatrics ; Skull* ; Spinal Dysraphism*

PURPOSE: The purpose of this study is to assess the usefulness of dynamic MR imaging after contrast enhancement with Gd-DTPA in the differential diagnosis of hepatic focal lesions. MATERIALS AND METHODS: The population consists of 22 cases of hepatocellular carcinoma, 44 cases of hemangioma, and five cases of metastasis. Diagnosis of hepatocellular carcinoma was made by surgery, fine needle biopsy, ultrasonography, CT and conventional angiography. Hemangioma was diagnosed on the basis of ultrasonography, CT, conventional spin-echo MRI and clinical data. Diagnosis of metastasis was done by fine needle aspiration biopsy. Dynamic and delayed images were obtained using 1.5T superconductive magnetom after Gd-DTPA(0.1mmol/kg) intravenous injection. Quantitative and qualitative evaluation was done for each lesion. RESULTS: Early contrast enhancement with rapid or gradual washout was noted in 15 lesions of hepatocellular carcinoma(68.2%) ;on the delayed images, no contrast enhancement was noted in 18 lesions(81. 8%). Peripheral contrast enhancement pattern was predominantly(86.4%) observed in hemangiomas during dynamic phase. On the delayed images, homogeneous and persistent contrast enhancement of masses were noted in all hemangiomas. Characteristic centripetal fill-in pattern was observed in 32 lesions of hemangioma (72.7%). Contrast inversion of masses during contrast enhancement study was noted in all hemangiomas, while continuous negative contrast was noted in hepatocellular carcinomas and metastases. CONCLUSION: Dynamic MR imaging after contrast enhancement with Gd-DTPA is an useful method in the differential diagnosis of hepatic focal lesions.
Angiography ; Biopsy ; Biopsy, Fine-Needle ; Carcinoma, Hepatocellular ; Diagnosis ; Diagnosis, Differential* ; Evaluation Studies as Topic ; Gadolinium DTPA ; Hemangioma* ; Injections, Intravenous ; Magnetic Resonance Imaging* ; Neoplasm Metastasis ; Ultrasonography

Achondroplasia is a rare disease and characterized by the combination of short extremities with an enlarged head and a trunk approximating normal size. We had experienced 4 cases of achondroplasia; they all showed stunted growth, short arms and legs, prominent forehead, flattening of the bridge of the nose and moderate degree of kyphcsis and one case was associated with hydrocephalus. X-ray showed the thickness of the bones and their irregular epiphyseal ends such as cupping, flaring and spurs. Intelligence seemed to be normal except one case. We had seen those patients at the age of 8 months, 6 months and 1year, 7months and 2 years, confirming achodroplasia by clinical, X-ray survey and biochemical study. Review of the references concerning achondroplasia was made briefly.
Achondroplasia* ; Arm ; Extremities ; Forehead ; Head ; Humans ; Hydrocephalus ; Intelligence ; Leg ; Nose ; Rare Diseases

Determination of the immunoglobulin M(IgM) in umbilical cord sera has been advocated as a screening test for intrauterine infection, since the IgM is produced by the fetus and is not transported across the placenta from mother. The low level of IgM in normal neonate is thought to reflect the infrequent encounter of antigenic stimuli by the futus, upon exposure to an appropriate antigen, however, the fetus is capable of increased IgM production, as has been doucumented in infant with rubella syndrome, cytomegalic inclusion disease, toxoplasmosis and syphilis. But until now we don't have the normal value of cord serum IgM in Korean neonate yet. So we performed the study to determine the normal value of serum IgM in Korean neonate and further more we try to compare the value of other condition such as congenital syphilis, maternal infection during pregnancy other than syphilis and congenital anomalies. Results were as followes: 1. Normal value of cord Igm was 11.83+/-9.92 mg % 2. There was no sexual difference 3. Lowest levele were noted at small weight(2500 gm upwards arrow) and short gestation period(28 wk upwards arrow) but not significant thereafter 4. There was no difference by matenal age and socioeconomic status 5. In congenital syphilis there was significant increment of cord IgM compared with normal group 6. There was no significant increment of cord ISM in cogenital anomalies 7. After 6 months, IgM levels were increased to adult level.
Adult ; Cytomegalovirus Infections ; Fetal Blood ; Fetus ; Humans ; Immunoglobulin M* ; Immunoglobulins* ; Infant ; Infant, Newborn ; Mass Screening ; Mothers ; Placenta ; Pregnancy ; Reference Values ; Rubella ; Social Class ; Syphilis ; Syphilis, Congenital ; Toxoplasmosis ; Umbilical Cord