No abstract available.
Heart Arrest* ; Resuscitation*

BACKGROUND: Activation of the c-Met pathway is involved in cancer progression and the prognosis. We aimed to identify any association of c-Met protein expression with a number of clinicopathologic variables including infection of human papillomavirus and Epstein-Barr virus (EBV) in head and neck carcinomas (HNCa). METHODS: Eighty-two cases were enrolled in this study. Expression of c-Met and p16 was investigated immunohistochemically. EBV was detected by in situ hybridization and amplification of the c-Met gene by fluorescence in situ hybridization. RESULTS: The c-Met protein was expressed in 41.5% (34/82), and gene amplification was found in 1.4% (1/71). High expression of c-Met was associated with the primary location of the tumor; the hypopharynx showed the highest expression, followed by the oral cavity, larynx, and nasal cavity. Squamous cell carcinoma expressed c-Met more frequently than undifferentiated carcinoma. Also, p16 immunoreactivity or EBV infection was associated with the tumor location and well-differentiated histologic type, but were not linked to c-Met expression. The patients with positive c-Met expression showed frequent lymph node metastasis. CONCLUSIONS: Activation of the c-Met pathway might be involved in a subset of HNCa. Cases showing positive c-Met expression should be carefully monitored because of the high probability of lymph node metastasis.
Carcinoma ; Carcinoma, Squamous Cell ; Epstein-Barr Virus Infections ; Fluorescence ; Gene Amplification ; Head ; Head and Neck Neoplasms ; Herpesvirus 4, Human ; Humans ; Hypopharynx ; In Situ Hybridization ; Larynx ; Lymph Nodes ; Mouth ; Nasal Cavity ; Neck ; Neoplasm Metastasis ; Prognosis ; Proto-Oncogene Proteins c-met

No abstract available.
Cell Proliferation* ; Interleukin-1* ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive*

To investigate the discriminative values of different lipid and lipoproteins in the presence and severity of coronary artery disease(CAD), liporotein profiles and other risk factors were measured in 333 patients age 30-69 years who were admitted at Severance Hospital from January 1980 to Agust 1986. The extent of atherosclerosis was quantified by a coronary atheosclerosis score(CAS) based on number and severity of lesions in eight proximal segments of the follows; 1) In age 30-49 and 50-69 groups, there were no significant differences of age, hypertension, smoking, diabetes, obesity to compare with control groups. 2) In age 30-49 group, the extent of CAD was more severe in male patients(1.7+/-0.7 vessel disease) than female(1.3+/-0.6 vessel disease)(P<0.05). But, no significant difference was showed between male(2.0+/-0.9 vessel disease) in age 50-69 group. CAS was significantly increased in male patients(6.1+/-3.7)to compare with female(3.7+/-2.6) in age 30-49 group(P<0.01). But, there was no difference in age 50-69 group. However, stronger liner correlations were demonstrated between the age and CAS in male patients(r=0.227, P<0.005) and in female patients(r=0.317, p<0.05). 3) Total cholesterol(TC), triglyceride(TG), HDL/c, HDL-TC and HDL-C/LDL-C were significantly associated with the presence of CAD in age 30-69 male patients; HoweverTC and LDL-C had disciriminatory value only for age 50-69 female patients. 4)The concentration of TC, LDL/C, HDL-C/TC and HDL_C/LDL-C showed a strong correlation with CAS in male patients, TC and LDL-C in female patents. But, HDL-C had no significant correlation with CAS on both groups. Above data suggest that TC, TG and HDL-C are the significants markers in man and TC and LDL-C on female for presence of CAD. The concentration of TC and LDL-C are related to the severity of CAD in both sexes. Further studies of lipoproteins and risk factors with large population are needed.
Adult* ; Atherosclerosis ; Coronary Artery Disease* ; Coronary Vessels* ; Female ; Humans ; Hypertension ; Lipoproteins* ; Male ; Obesity ; Risk Factors ; Smoke ; Smoking

BACKGROUND AND OBJECTIVES: Recent data about trans-radial approach showed its usefulness in achieving the high procedural success rate and low local complications even though the size of the radial artery is small compared to that of the femoral artery. Therefore, we want to evaluate the size of the radial artery and the feasibility of the trans-radial coronary angiography as a routine technique. MATERIALS AND METHOD: Trans-radial coronary angiography (TRCA) was successful in 619 cases. The size of the radial artery was measured using 2D-ultrasonography. TRCA was tried with 4 Fr catheters. We divided the cases into two groups; early phase, 106 cases and late phase, 513 cases and compared the procedure time, catheter number used, and complications between 2 groups. RESULTS: The size of the radial artery was 2.7+/-0.4 mm in diameter and this of the men was larger than that of women (p 0.05). TRCA was performed successfully in 513 cases among 521 cases of late phase (98.5%) and crossover to femoral artery occurred in 8 cases (1.5%). The fluoroscopic time and total procedure time of the late phase (6.5+/-4.0 min, 22.9+/-11.3 min) were significantly lower than those of early phase (11.5+/-6.3 min, 31.2+/-13.7 min) (p<0.01). The average number of catheters used for coronary angiography was 1.8+/-1.0. There were 6 cases (1%) of radial artery occlusion and 1 case (0.2%) of radial artery perforation without hand ischemia. CONCLUSION: Based on the adequate size of the radial artery, high success rate and low complications, TRCA might be a safe and become a routine diagnostic technique.
Catheters ; Coronary Angiography* ; Female ; Femoral Artery ; Gangwon-do* ; Hand ; Humans ; Ischemia ; Male ; Radial Artery

BACKGROUND: Elastic recoil contributes to the residual lumen reduction immediately after PTCA. We evaluated the factors to influence on immediate elastic recoil after the successful PTCA. METHODS: 88 patients(96 lesions) were studied by quantitative angiography. Angiograms were obtained in two identical near orthogonal projection before PTCA and immediately after the last balloon deflation. RESULTS: Immediately after PTCA, minimal luminal diameter increased from 0.7+/-0.6mm to 1.9+/-0.6mm and percent diameter stenosis was reduced from 77+/-20 to 34+/-21%. The calculated mean elastic recoil was 0.5+/-0.7mm in diameter and % elastic recoils were lesser both in calcified(3+/-23 vs 23+/-24%, p=0.04) and thrombotic(9+/-20 vs 23+/-35%, p=0.02) lesions. The elastic recoil increased significantly according to the inflation diameter of balloon(r=0.32, p<0.01. No significant correlation between the immediate elastic recoil and age, sex, risk factors, eccentricity and lesion length was shown. CONCLUSION: The elastic recoil immediately after a successful PTCA was dependent on the existance of calcium and thrombus on the target lesion and on the balloon size at the maximal inflation.
Angiography ; Angioplasty, Balloon, Coronary* ; Calcium ; Constriction, Pathologic ; Inflation, Economic ; Phenobarbital ; Risk Factors ; Thrombosis

BACKGROUND: Patency of the infarct-related coronary artery may influence LV remodeling, provide a more stable electrophysiologic milieu and improves the outcome of patient with acute myocardioal infarction. The result from clinical trials have confirmed that early reperfusion in humans induced by a thrombolytic agent is associated with limitation of infarct size, preservation of ventricular function, and improved survival. The purpose of this study was evaluate the effect of thrombolytic therapy on the severity of the residual stenosis, antegrade flow of infarct-related coronary artery after acute myocardial infarction, and investigate left ventricular function and regianal wall motion abnormality depending on the thrombolytic therapy. METHODS: A retrosperctive study was performed in 166 patients with acute myocardial infarction with underwent coronary angiography within 8 days after acute attack from Oct. 1990 to Sep. 1994. Patients were grouped as thrombolysis group(n=64) who had undertaken urokinase infusion therapy within 6 hours of symptom onset and conservatively treated group(n=102) who had not received thrombolytic trerapy. At 8+/-7days, cardiac catheterization was performed. Status of the infarct related artery was assessed by resiudal % diameter stenosis, TIMI and collateral trading. Left ventricular function and wall motion were analyzed. RESULTS: 1) The was no statistical differenccs in age, sex and risk factors(diabetes, hypertension, smoking and hypercholesterolemia)between two groups. 2) The peak serum CK level was higher(2719+/-2333 vs 1951+/-2064 IU/L) and time to peak CK enzyme level was shorter(19+/-13 vs 32+/-24 hr) in thrombolysis group than conservatively treated group. 3) There was lower incidence of total occlusion(12.5% vs 30.4%), residual % diameter stenosis of infarct-related artery(67+/-34% vs 80+/-27%) and better antegrade flow(TIMI grade 0-1, 12.5% vs 32.4%) in thrombolysis group than conservatively treated group(p<0.05). 4) There were no statistical differences of ejection fraction(51+/-15 vs 51+/-14%). left ventricular end diastolic pressure(21+/-10 vs 21+/-16mmHg) and regional wall motion score(8.6+/-3.4 vs 9.1+/-3.1) between thrombolysis group and conservatively treated group(p>0.05). CONCLUSION: Thrombolytic therapy in acute myocardial infarction resulted in dquisition of early infarct-related arterial patency, effectiove antegrade flow and reduced incidence of totoal occlusion of infarct-related artery. Left ventricular ejection fraciton, regional wall motion score was not affected by thrombolytioc therapy in inhospital period.
Arteries ; Cardiac Catheterization ; Cardiac Catheters ; Constriction, Pathologic ; Coronary Angiography ; Coronary Vessels* ; Humans ; Hypertension ; Incidence ; Infarction ; Myocardial Infarction* ; Reperfusion ; Smoke ; Smoking ; Thrombolytic Therapy ; Urokinase-Type Plasminogen Activator ; Ventricular Function ; Ventricular Function, Left*

Percutaneous transluminal renal angioplasty(PTRA) has become the treatment of choice for major renal artery stenosis. Nonetheless, about 10% of renal artery stenosis could not be properly dilated and 10-15% had a recurrence among the parients successfully dilated. Especially, PTRA in Takayasu's arteritis has technical diffculties due to the tough, noncompliant nature of the stenosis, which art difficult to cross and resist the respeated, prolonged balloon inflations. Intraluminal renal artery stent placement in unsuccessful balloon angioplasty and unsuitable lesions to PTRA may be an attractive approach to improve flow conditions. We report two cases of proximal renal artery stenosis caused by Takayasu's arteritis, who treated with intraluminal renal stenting(Palmaz-Schatz biliary stent). In both cases, clinical and angiographical improvement was achieved.
Angioplasty, Balloon ; Constriction, Pathologic ; Recurrence ; Renal Artery Obstruction* ; Renal Artery* ; Stents* ; Takayasu Arteritis*

Seventy one children aged 3 months and 8 months with a foreign body in the airway were analysed. Most of the patients were less than 3 years of age, and male to female ratio 2.6:1. Most foreign bodies were food materials (58.2%), metallic bodies (20.9%) and plastic materials(13.4%). Of all the foreign bodies, 61 cases were lodged in the main bronchi and 3 cases were lodged in the larynx or trachea. Common symptoms and signs were cough, dyspnea, mild pyrexia, recurrent respiratory tract infection, decreased air entry, cyanosis and rales. The most common roentgenographic finding was obstructive emphysema (61.2%). A positive history of foreign body aspiration was obtained in 77.5% of the patients and it was found that carelessness of some sort is responsible in almost all the cases. Of the foreign bodies removed, 84.6% were done bronchoscopy. Direct laryngoscopy was performed in 4.6% of patients. Complications were involved in 19.7% of the cases with bronchoscopy. Three patients died of septic shock, asphyxia and hypoxic brain damage respectively.
Asphyxia ; Bronchi ; Bronchoscopy ; Child ; Cough ; Cyanosis ; Dyspnea ; Emphysema ; Female ; Fever ; Foreign Bodies* ; Humans ; Hypoxia, Brain ; Laryngoscopy ; Larynx ; Male ; Plastics ; Respiratory Sounds ; Respiratory Tract Infections ; Shock, Septic ; Trachea

Seventy one children aged 3 months and 8 months with a foreign body in the airway were analysed. Most of the patients were less than 3 years of age, and male to female ratio 2.6:1. Most foreign bodies were food materials (58.2%), metallic bodies (20.9%) and plastic materials(13.4%). Of all the foreign bodies, 61 cases were lodged in the main bronchi and 3 cases were lodged in the larynx or trachea. Common symptoms and signs were cough, dyspnea, mild pyrexia, recurrent respiratory tract infection, decreased air entry, cyanosis and rales. The most common roentgenographic finding was obstructive emphysema (61.2%). A positive history of foreign body aspiration was obtained in 77.5% of the patients and it was found that carelessness of some sort is responsible in almost all the cases. Of the foreign bodies removed, 84.6% were done bronchoscopy. Direct laryngoscopy was performed in 4.6% of patients. Complications were involved in 19.7% of the cases with bronchoscopy. Three patients died of septic shock, asphyxia and hypoxic brain damage respectively.
Asphyxia ; Bronchi ; Bronchoscopy ; Child ; Cough ; Cyanosis ; Dyspnea ; Emphysema ; Female ; Fever ; Foreign Bodies* ; Humans ; Hypoxia, Brain ; Laryngoscopy ; Larynx ; Male ; Plastics ; Respiratory Sounds ; Respiratory Tract Infections ; Shock, Septic ; Trachea