1.Effects of biochanic A on mouse lung tumor and lymphocyte proliferative.
Yun Sil LEE ; Tae Hwan KIM ; Ja June JANG
Journal of the Korean Cancer Association 1991;23(3):479-484
No abstract available.
Animals
;
Lung*
;
Lymphocytes*
;
Mice*
2.Use of Medical Resources by Preterm Infants Born at Less than 33 Weeks' Gestation Following Discharge from the Neonatal Intensive Care Unit in Korea.
Journal of Korean Medical Science 2015;30(Suppl 1):S95-S103
This study was aimed to provide data on the use of medical resources by preterm infants following discharge from the neonatal intensive care unit (NICU). The cohort included preterm infants (n=2,351) born at 22-32 weeks' gestation who were discharged from the NICUs of 44 Korean hospitals between April 2009 to March 2010. Mean duration of post-discharge follow-up was 425+/-237 days. After discharge from the NICU, 94.5% of total infants visited a pediatric outpatient clinic (11.5+/-9.8 mean visits), 42.9% visited a pediatric clinic for respiratory problems irregularly (4.9+/-6.6 mean visits), and 31.1% utilized emergency center at least once. Among all visits to the emergency center, 24.7% resulted in readmission and 50.8% of those visits were due to respiratory problems. At least one episode of readmission was required by 33.6% (788/2,346) of total infants, and 18.4% (431/2,346) of total infants were readmitted with respiratory problems at least once. Among all infants readmitted for respiratory problems, 16.2% (70/341) were diagnosed with respiratory syncytial virus infection which accounted for 30.3% of viral etiologies confirmed by laboratory testing. Infants born at <30 weeks' gestation had more frequent total readmission and respiratory readmission than those > or =30 weeks' gestation (2+/-1.7 vs. 1.7+/-1.2, P=0.009, 1.8+/-1.2 vs. 1.5+/-1.1, 0.027, respectively). Overall, use of medical resources is common, and respiratory problems are the leading cause of use of medical resources. Total readmissions and respiratory readmissions are more frequent in more immature infants.
Cohort Studies
;
Databases, Factual
;
Emergency Service, Hospital
;
Female
;
Follow-Up Studies
;
Gestational Age
;
Humans
;
Infant
;
Infant, Newborn
;
Infant, Premature
;
Infant, Premature, Diseases/*pathology
;
Intensive Care Units, Neonatal
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Male
;
Patient Readmission
;
Republic of Korea
;
Respiratory Distress Syndrome, Newborn/*pathology
;
Retrospective Studies
3.Erratum: Correction of Error in Result: Comparison of Follow-up Courses after Discharge from Neonatal Intensive Care Unit between Very Low Birth Weight Infants with and without Home Oxygen
Ji Sook KIM ; Jae Won SHIM ; Jang Hoon LEE ; Yun Sil CHANG ;
Journal of Korean Medical Science 2019;34(10):e96-
An important error in the result of Table 3 was confirmed in the article.
4.Heart Disease Screening for Primary School Children.
Chang Yee HONG ; In Sil LEE ; Hee Ju KIM ; Jung Hwan CHOI ; Hae Il CHEONG ; Jung Yun CHOI ; Yong Soo YUN
Journal of the Korean Pediatric Society 1985;28(3):258-262
No abstract available.
Child*
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Heart Diseases*
;
Heart*
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Humans
;
Mass Screening*
5.The effect of lipopolysaccharide on the migration of osteoclast precursors.
Hee Young LEE ; Dae Sil LEE ; Jeong Heon CHA ; Yun Jung YOO
The Journal of the Korean Academy of Periodontology 2007;37(1):23-33
No abstract available.
Osteoclasts*
6.Influence of gestational age at exposure on the prenatal effects of gamma-radiation.
Sung Ho KIM ; Se Ra KIM ; Yun Sil LEE ; Tae Hwan KIM ; Sung Kee JO ; Cha Soo LEE
Journal of Veterinary Science 2001;2(1):37-42
The objective of this investigation was to evaluate the influence of gestational age at exposure on the prenatal effects of gamma-radiation. Pregnant ICR mice were exposed to a single dose of 2.0 Gy gamma-radiation at a gestational 2.5 to 15.5 days post-coitus (p.c.). The animals were sacrificed on day 18 of gestation and the fetuses were examined for mortality, growth retardation, change in head size and any other morphological abnormalities. The only demonstrable effect of irradiation during the preimplantation period was an increase in prenatal mortality. Resorptions were maximal on post-exposure day 2.5 after conception. The pre-implantation irradiated embryos which survived did not show any major fetal abnormalities. Small head, growth retardation, cleft palate, dilatation of the cerebral ventricle, dilatation of the renal pelvis and abnormalities of the extremities and tail were prominent after exposure during the organogenesis period, especially on day 11.5 of gestation. Our results indicate that the late period of organogenesis in the mouse is a particularly sensitive phase in terms of the development of the brain, skull and extremities.
Abnormalities, Radiation-Induced/*pathology
;
Animals
;
Bone and Bones/abnormalities/radiation effects
;
Female
;
Fetal Death
;
*Gamma Rays
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*Gestational Age
;
Mice
;
Mice, Inbred ICR
;
Pregnancy
;
Pregnancy, Animal/*radiation effects
;
Prenatal Exposure Delayed Effects
7.A Case of Primary Tuberculosis of the Lacrimal Sac Presenting as Epiphora
Sang Yun LEE ; Sangwook PARK ; Jong-Sil LEE ; Yung Jin JEON
Korean Journal of Otolaryngology - Head and Neck Surgery 2021;64(3):202-206
Extra-pulmonary tuberculosis usually progresses as a secondary infection from pulmonary tuberculosis, and tuberculosis of the head and neck region. Tuberculosis of ocular and periocular areas, however, is a rare disease. Among ocular tuberculosis involving the adnexal structures, a few lacrimal sac tuberculosis has been reported. We recently experienced a case of lacrimal sac tuberculosis presenting as epiphora. Examination revealed bilateral nasolacrimal duct obstruction and the patient underwent endoscopic endonasal dacryocystorhinostomy. During the operation, a biopsy taken from the unhealthy looking lacrimal sac filled with caseous necrotic tissue was suggestive of tuberculosis. Histopathological features and further systemic evaluation confirmed tuberculosis. She was treated medically with anti-tubercular agents. The new opening of the lacrimal sac was patent and epiphora was resolved successfully at a year follow up. This report highlights the requirement of high suspicion of tuberculosis, even in the nasolacrimal drainage system.
8.Anticarcinogenic Effect of Panax ginseng C.A. Meyer and Identification of Active Compounds.
Taik Koo YUN ; Yun Sil LEE ; You Hui LEE ; Shin Il KIM ; Hyo Yung YUN
Journal of Korean Medical Science 2001;16(Suppl):S6-S18
The failure to improve the five-year survival rate of cancer patients, from one in three in the 1960s to one in two in the 1970s, stimulated awareness of the importance of primary prevention of cancer. Korean investigators carried out extensive long-term anticarcinogenicity experiments with 2000 newborn mice to investigate whether Panax ginseng C.A. Meyer inhibited carcinogenesis induced by several chemical carcinogens in 1978. There was a 22% decrease (p<0.05) in the incidence of urethane induced lung adenoma by the combined use of red ginseng extract. In the group sacrificed at 56 weeks after the treatment with aflatoxin B1, the incidence of hepatoma significantly decreased to 75% by the addition of red ginseng extract (p<0.05). The result showed that natural products can provide hope for human cancer prevention. By the newly established '9 week medium-term anticarcinogenicity test model of lung tumors in mice' (Yun's model), we confirmed significant anticarcinogenic effects of powders and extracts of the 6- yr-old dried fresh ginseng, 5- and 6-yr old white ginsengs, and 4-, 5-, and 6-yr old red ginseng. We also demonstrated that the anticarcinogencity of ginseng was more prominent in aged or heat treated extracts of ginseng and red ginseng made by steaming. To investigate the active components for cancer prevention, several fractions of 6-yr old fresh ginseng and red ginseng, four semi-synthetic ginsenoside Rh1, Rh2, Rg3 and Rg5, major saponin components in red ginseng, were prepared. Among the ginsenosides, Rg3 and Rg5 showed statistically significant reduction of lung tumor incidence and Rh2 had a tendency of decreasing the incidence. Ginsenoside Rg3, Rg5 and Rh2 were found to be active anticarcinogenic compounds. Rg3, Rg5 and Rh2 are active components in red ginseng, and they prevent cancer either singularly or synergistically.
Animal
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*Anticarcinogenic Agents
;
Disease Models, Animal
;
Fractionation
;
Human
;
Korea
;
Mice
;
Molecular Structure
;
*Panax/chemistry/growth & development
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Plant Extracts/analysis
;
Time Factors
9.A Case of chronic necrotizing pulmonary aspergillosis with pulmonary artery aneurysm.
Hwi Jong KIM ; Hyo Young CHUNG ; Soo Hee KIM ; Ji Chul YUN ; Jong Deog LEE ; Young Sil HWANG
Tuberculosis and Respiratory Diseases 2000;49(1):105-110
Pulmonary aspergillosis is classified as a saprophytic, allergic, and invasive disease. Chronic necrotizing pulmonary aspergillosis is categorized as an invasive pulmonary aspergillosis. Most invasive pulmonary aspergillosis have acute and toxic clinical features but chronic necrotizing pulmonary aspergillosis is characterized by a sub-acute infection, most commonly seen in patients with altered local defense system from preexisting pulmonary disease of in mild immunocompromised patients. Pulmonary artery aneurysm due to this infection is termed as a mycotic aneurysm, etiology of which are tuberculosis, syphilis, bacteria and fungus. We report a case chronic necrotizing pulmonary aspergillosis complicating pulmonary aneurysm is a 62 year-old man who was presented with cough, sputum, and fever. Chest radiographs showed a rapid, progressive cavitary lesion and pulmonary artery aneurysm. Angioinvastion of aspergillus was revealed by pathology after operative removal of left upper lobe containing the pulmonary artery aneurysm. He was treated with itraconazole.
Aneurysm*
;
Aneurysm, Infected
;
Aspergillus
;
Bacteria
;
Cough
;
Fever
;
Fungi
;
Humans
;
Immunocompromised Host
;
Invasive Pulmonary Aspergillosis*
;
Itraconazole
;
Lung Diseases
;
Pathology
;
Pulmonary Artery*
;
Pulmonary Aspergillosis
;
Radiography, Thoracic
;
Sputum
;
Syphilis
;
Tuberculosis
10.Respiratory Syncytial Virus Related Readmission in Preterm Infants Less than 34 weeks' Gestation Following Discharge from a Neonatal Intensive Care Unit in Korea.
Jang Hoon LEE ; Chun Soo KIM ; Yun Sil CHANG ; Jung Hwan CHOI
Journal of Korean Medical Science 2015;30(Suppl 1):S104-S110
This study was done to evaluate respiratory syncytial virus (RSV) related readmission (RRR) and risk factors of RRR in preterm infants < 34 weeks gestational age (GA) within 1 yr following discharge from the neonatal intensive care unit (NICU). Infants (n = 1,140) who were born and admitted to the NICUs of 46 hospitals in Korea from April to September 2012, and followed up for > 1 yr after discharge from the NICU, were enrolled. The average GA and birth weight of the infants was 30(+5) +/- 2(+5) weeks and 1,502 +/- 474 g, respectively. The RRR rate of enrolled infants was 8.4% (96/1,140), and RSV accounted for 58.2% of respiratory readmissions of infants who had laboratory tests confirming etiological viruses. Living with elder siblings (odd ratio [OR], 2.68; 95% confidence interval [CI], 1.68-4.28; P < 0.001), and bronchopulmonary dysplasia (BPD) (OR, 2.95; 95% CI, 1.44-6.04; P = 0.003, BPD vs. none) increased the risk of RRR. Palivizumab prophylaxis (OR, 0.06; 95% CI, 0.03-0.13; P < 0.001) decreased the risk of RRR. The risk of RRR of infants of 32-33 weeks' gestation was lower than that of infants < 26 weeks' gestation (OR, 0.11; 95% CI, 0.02-0.53; P = 0.006). This was a nationwide study that evaluated the rate and associated risk factors of RRR in Korean preterm infants. Preterm infants with BPD or living with siblings should be supervised, and administration of palivizumab to prevent RRR should be considered.
Antiviral Agents/therapeutic use
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Birth Weight
;
Bronchopulmonary Dysplasia/drug therapy/pathology
;
Female
;
Gestational Age
;
Humans
;
Infant
;
Infant, Newborn
;
Infant, Premature
;
Intensive Care Units, Neonatal
;
Male
;
Odds Ratio
;
Palivizumab/therapeutic use
;
Patient Discharge
;
Patient Readmission
;
Republic of Korea
;
Respiratory Syncytial Virus Infections/drug therapy/*pathology/virology
;
Respiratory Syncytial Viruses/*isolation & purification
;
Risk Factors
;
Siblings