1.Hepatocellular Carcinoma with Severe Hypoglycemia: Involvement of Insulin-ike Growth Factor I, II and Insulin-ike Growth Factor Binding Proteins.
Seok Joo KIM ; Bo Yeong YUN ; Ha Chin CHOI
The Korean Journal of Hepatology 1999;5(4):332-337
We report a case of hepatocellular carcinoma presented with severe hypoglycemia. Computerized tomography and ultrasonography revealed a massive bilateral tumor with portal vein thrombosis. The levels of IGF-I (113 ng/mL) and IGFBP- (815 ng/mL) measured in the plasma, were lower than normal range. There was strong immunoreactivity of IGF- and IGF-I in immunohistochemical stain of tumor cells.
Carcinoma, Hepatocellular*
;
Carrier Proteins*
;
Fibrinogen*
;
Hypoglycemia*
;
Insulin-Like Growth Factor Binding Proteins
;
Insulin-Like Growth Factor I
;
Plasma
;
Reference Values
;
Ultrasonography
;
Venous Thrombosis
2.Lumbar Juxtafacet Cyst Treated with Direct Needle Aspiration Under the Guidance of Image Intensifier
Sung-Ha HONG ; Seung-Pyo SUH ; Seok-Ha HWANG ; Yun-Seong KIM
The Journal of the Korean Orthopaedic Association 2020;55(3):261-265
A lumbar juxtafacet cyst is a rare disease that causes low back pain, radiculopathy and neurological claudication by compressing the nerve roots. A 34-year-old male complained of severe low back pain and radicular pain in the right lower extremity. Magnetic resonance images revealed a cyst at the lateral recess of the spinal canal between the L3-4 disc and posterior facet joint that extended to the L4 body level. Under the guidance of an image intensifier, needle aspiration of the cyst was performed, which extracted 1.5 ml of serous, yellowish colored fluid. After the aspiration, the symptoms subsided dramatically. The follow-up magnetic resonance images showed no recurrence of the cyst. To the best of the author’s knowledge, there are no reports of lumbar juxtafacet cyst treated with needle aspiration in Korea. This case is reported with a review of the relevant literature.
3.The surgical management of extensive nasopharyngeal angiofibroma with combined intracranial and extracranial approach.
Chul Hee LEE ; Ha Won JUNG ; Hun Jong DONG ; Yeong Seok YUN ; Won Seok YU ; Sung Hwa HONG
Korean Journal of Otolaryngology - Head and Neck Surgery 1991;34(2):376-386
No abstract available.
Angiofibroma*
4.Microbiome of Genitourinary Tumors: Especially in Prostate Cancer and Kidney Cancer
Kyungchan MIN ; Seok Joong YUN ; Hansoo PARK ; Yun-Sok HA
Korean Journal of Urological Oncology 2021;19(3):136-147
Human body contains diverse microbes. Different microbes are identified at different organs. Urine was thought as sterile, but according to progression in important technologies like 16S rRNA gene sequencing and expanded quantitative urine culture, it is known that diverse microbes exist in genitourinary tract. Microbiome contains the microbes and surrounding microenvironments. In addition to urologic difficulties like interstitial cystitis or chronic prostatitis, malignancies are thought to be related to microbiomes. In this review, we summarized several studies in urologic malignancies, especially prostate cancer and kidney cancer.
5.Microbiome of Genitourinary Tumors: Especially in Prostate Cancer and Kidney Cancer
Kyungchan MIN ; Seok Joong YUN ; Hansoo PARK ; Yun-Sok HA
Korean Journal of Urological Oncology 2021;19(3):136-147
Human body contains diverse microbes. Different microbes are identified at different organs. Urine was thought as sterile, but according to progression in important technologies like 16S rRNA gene sequencing and expanded quantitative urine culture, it is known that diverse microbes exist in genitourinary tract. Microbiome contains the microbes and surrounding microenvironments. In addition to urologic difficulties like interstitial cystitis or chronic prostatitis, malignancies are thought to be related to microbiomes. In this review, we summarized several studies in urologic malignancies, especially prostate cancer and kidney cancer.
6.Do Knots Matter in Superior Labrum Anterior to Posterior Lesions Repair?.
Hyeon Jang JEONG ; Ho Yun JOUNG ; Dae Ha KIM ; Sung Min RHEE ; Seok Hoon YANG ; Woo KIM ; Joo Han OH
Clinics in Shoulder and Elbow 2017;20(2):68-76
BACKGROUND: In general, the outcomes of arthroscopic repair for superior labrum anterior to posterior lesions (SLAP) are favorable, however, persistent pain and limitation of motion are not rare complications. One of the possible cause is a “knot-ache”. This study evaluated the results of reoperation of symptomatic recurrent SLAP lesions and asked whether the knot is associated with postoperative complications. METHODS: Between 2005 and 2015, a total of 11 patients who had undergone arthroscopic SLAP repair were reoperated for recurrent symptomatic SLAP lesion. By retrospective chart review, operative findings, the visual analogue scale for pain (pVAS), the range of motion (ROM), and functional scores were analyzed. RESULTS: The mean age of the study participants was 38.3 years, and the mean follow-up period was 42.5 months. In the primary operation, there were nine cases of repairs with conventional knot-tying anchors and three cases with knotless anchors. Impingement of the knots during abduction and external rotation of the shoulder was observed in the all cases with knot-tying anchors. The mean pVAS, ROM, and functional scores significantly improved with reoperation. At the final follow-up, the mean satisfaction VAS was 8.3. CONCLUSIONS: The knots of suture anchor maybe a possible etiology of the pain, which we termed a “knot-ache”. Considering that reoperation is performed due to pain after primary repair, the use of knotless suture anchor may have benefits of eliminating one of possible cause, “knot-ache”. Therefore, authors suggest the use of knotless anchors during reoperation for recurrent or recalcitrant pain after primary SLAP repair.
7.A Case of Cystic Germinoma in Bilateral Frontal Region.
Dong Seok HAN ; Hack Gun BAE ; Kyeong Seok LEE ; IL Gyu YUN ; In Soo LEE ; Seung Ha YANG
Journal of Korean Neurosurgical Society 1988;17(2):347-352
The authors present a case of germinoma in corpus callosum extending to the both frontal lobes with cystic change, in a 27-year-old male. Bilaterallity and cystic change simulated a cystic astrocytoma or a butterfly glioblastoma. The interest in this case is due to the unusual location and the nature of the tumor.
Adult
;
Astrocytoma
;
Butterflies
;
Corpus Callosum
;
Frontal Lobe
;
Germinoma*
;
Glioblastoma
;
Humans
;
Male
8.Utility of Smo as a Prognostic Marker for Human Bladder Tumors.
Yun Sok HA ; Seok Joong YUN ; Yong June KIM ; Sang Cheol LEE ; Wun Jae KIM
Korean Journal of Urology 2007;48(10):997-1003
PURPOSE: Smoothened(Smo) encodes a 1,024 amino acid transmembrane protein that acts as a transducer of the hedgehog(Hh) signal and maps to 7q31-q32 in humans. In the absence of Hh, Patched(Ptc) prevents Smo from signaling. When M-Hh-N binds to Ptc, however, Smo is free to upregulate downstream genes in the network. Activating mutations in Smo have been identified in sporadic basal cell carcinomas. This study was performed to evaluate the significance of Smo expression in humanzbladder cancer. MATERIALS AND METHODS: Tumor tissues were obtained from 140 patients with bladder cancer and normal bladder mucosa were acquired from 17 patients without bladder cancer as controls. Smo expression was assessed from paraffin sections of tissues using immunohistochemistry and graded on a scale of 0-12 according to the intensity and rate of staining. Differences of Smo expression between the bladder tumors and normal mucosa were compared. The relationships between their expression and the pathological or clinical characteristics such as tumor stage, grade, recurrence, and progression were also analyzed. RESULTS: There was no difference in the Smo expression in comparisons between the bladder cancers and the normal tissues(4.96+/-1.92 vs.4.52+/-0.87, p=0.111). Superficial bladder tumors had a higher Smo expression compared with normal tissues(0.005). Smo expression in the superficial and low-grade bladder tumors were higher than in the invasive and high-grade bladder tumors(p=0.002 and 0.001, respectively). The progression status was correlated with Smo expression but not the recurrence status(p=0.041 and 0.357, respectively). However, the Smo expression levels were not associated with the overall survival of patients(p=0.406). CONCLUSIONS: The results of this study showed that the enhanced expression of Smo was correlated with superficial, low-grade bladder cancer and tumors without progression. These results suggest that Smo is closely correlated with the differentiation and progression of bladder cancer and may, therefore, be useful as a prognostic marker for bladder cancer in the clinical setting.
Carcinoma, Basal Cell
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Humans*
;
Immunohistochemistry
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Mucous Membrane
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Paraffin
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Recurrence
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Transducers
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Urinary Bladder Neoplasms*
;
Urinary Bladder*
9.Comparison of Metabolic Risk Factors in Urolithiasis Patients according to Family History.
Cheol PARK ; Yun Sok HA ; Yong June KIM ; Seok Joong YUN ; Sang Cheol LEE ; Wun Jae KIM
Korean Journal of Urology 2010;51(1):50-53
PURPOSE: Urolithiasis develops more frequently in patients with a family history (FHx). However, little is known about risk factors in stone formers with a FHx. The aim of this study was to examine the clinico-metabolic characteristics of urinary stone formers according to FHx. MATERIALS AND METHODS: A database of 1,068 stone formers who underwent a complete metabolic evaluation was reviewed. The patients were divided into two groups on the basis of the presence of a FHx. Clinical factors and metabolic parameters were compared between the two groups. RESULTS: There were no significant differences in clinical characteristics, such as gender, age, body mass index, stone episodes, or multiple stones, between the two groups (p>0.05, respectively). Compared with stone formers without a FHx, however, serum calcium concentrations were more elevated in stone formers with a FHx. Also, the urinary excretion of calcium was higher in stone formers with a FHx than in those without a FHx. Other urinary metabolites showed no significant differences between the two groups (p>0.05, respectively). CONCLUSIONS: Our study revealed that stone formers with a FHx had increased urinary calcium excretion as well as elevated concentrations of serum calcium. This finding suggests that urolithiasis in stone formers with a FHx may be associated with calcium metabolic abnormalities.
Body Mass Index
;
Calcium
;
Family Characteristics
;
Humans
;
Risk Factors
;
Urinary Calculi
;
Urolithiasis
10.Preoperative Underweight Patients with Upper Tract Urothelial Carcinoma Survive Less after Radical Nephroureterectomy.
Ho Won KANG ; Hae Do JUNG ; Yun Sok HA ; Tae Hwan KIM ; Tae Gyun KWON ; Seok Soo BYUN ; Seok Joong YUN ; Wun Jae KIM ; Young Deuk CHOI
Journal of Korean Medical Science 2015;30(10):1483-1489
The prognostic impact of body mass index (BMI) in patients with upper tract urothelial carcinoma (UTUC) is an ongoing debate. Our study aimed to investigate the prognostic role of BMI in patients treated with radical nephroureterectomy (RNU) for UTUC from a multi-institutional Korean collaboration. We retrospectively reviewed data from 440 patients who underwent RNU for UTUC at four institutions in Korea. To avoid biasing the survival estimates, patients who had previous or concomitant muscle-invasive bladder tumors were excluded. BMI was categorized into approximate quartiles with the lowest quartile assigned to the reference group. Kaplan-Meier and multivariate Cox regression analyses were performed to assess the influence of BMI on survival. The lower quartile BMI group showed significantly increased overall mortality (OM) and cancer specific mortality (CSM) compared to the 25%-50% quartiles and upper quartile BMI groups. Kaplan-Meier estimates showed similar results. Based on multivariate Cox regression analysis, preoperative BMI as a continuous variable was an independent predictor for OM and CSM. In conclusion, preoperative underweight patients with UTUC in Korea survive less after RNU. Preoperative BMI may provide additional prognostic information to establish risk factors.
Aged
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Asian Continental Ancestry Group
;
Body Mass Index
;
Carcinoma, Transitional Cell/*mortality
;
Cystectomy/*mortality
;
Female
;
Humans
;
Kidney Pelvis/surgery
;
Male
;
Nephrectomy/*mortality
;
Republic of Korea
;
Retrospective Studies
;
Thinness/*mortality
;
Ureter/surgery
;
Urinary Bladder/surgery
;
Urologic Neoplasms/*mortality/pathology/*surgery
;
Urothelium/pathology/*surgery