2.Transcription factor Forkhead-box A1 and breast cancer.
Chinese Journal of Pathology 2010;39(2):136-139
Animals
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Antineoplastic Agents
;
therapeutic use
;
Breast Neoplasms
;
drug therapy
;
genetics
;
metabolism
;
Cyclin-Dependent Kinase Inhibitor p27
;
Fenretinide
;
therapeutic use
;
Hepatocyte Nuclear Factor 3-alpha
;
genetics
;
metabolism
;
Humans
;
Intracellular Signaling Peptides and Proteins
;
metabolism
;
Prognosis
;
Receptors, Estrogen
;
metabolism
4.Molecular pathology of inflammatory breast cancer.
Chinese Journal of Pathology 2010;39(1):59-62
Cadherins
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metabolism
;
Female
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Gene Expression Profiling
;
Humans
;
Inflammatory Breast Neoplasms
;
genetics
;
metabolism
;
pathology
;
NF-kappa B
;
metabolism
;
Receptor, ErbB-2
;
metabolism
;
Receptor, Notch3
;
Receptors, CCR7
;
metabolism
;
Receptors, CXCR4
;
metabolism
;
Receptors, Notch
;
metabolism
5.MicroRNA and breast cancer-related hormone receptors.
Jing ZHANG ; Yun NIU ; Qi YU
Chinese Journal of Pathology 2011;40(3):212-214
6.A study of single-walled carbon nanotubes modified by organics of the phthalocyanine category
Zhonghui XU ; Haibo NIU ; Yun JIANG
Journal of Pharmaceutical Analysis 2008;20(3):193-197
Organics of the phthalocyanine category have very good nonlinear optical properties. The single-walled carbon nanotubes were modified by using the phenoxy phthalocyanine. Characterization analysis was made by means of the transmission electron microscope (TEM), ultraviolet visible absorptive spectra, fluorescent spectra and Raman spectra. Under the TEM, it was observed that the composite looked like sugarcoated haws. By comparing the ultraviolet visible absorptive spectra before and after absorption, it was disclosed that the spectral intensity and the intensity of the peaks in the fluorescent spectra dropped remarkably. This shows that the single-walled carbon nanotubes have absorbed a large number of phenoxy phthalocyanines. Raman analysis revealed that in the Raman spectra, the position of the main peaks of the single-walled carbon nanotubes after absorption moved in the direction of long waves. The analysis suggests that the movement of the Raman spectra results from the change in the state of the single-walled carbon nanotubes before and after absorption.
7.SCF protects the cortical neuron from apoptotic cell death in diabetic mice
Yun LUO ; Wenjing ZHU ; Fengnan NIU ; Yun XU
Chinese Journal of Nervous and Mental Diseases 2009;35(12):730-733
Objective To investigate the role of SCF on neuronal apoptosis induced by diabetes and its possible mechanism.Methods Twenty-seven male C57 mice were randomly divided into control group,diabetes group,and diabe-tes plus stem cell factor(SCF)group.The diabetic mice were induced by streptozotocin.TUNEL staining was used to assess neuronal apoptosis and western blot were used to detect the protein level of BCL-2,BAX,CASPASE 3 and P-ERK/ERK.Results Compared with the controls,the number of apoptotic neuron death and the protein levels of active CASPASE 3 were significantly increased in the cortex of diabetic mice.Treatment with SCF significantly reduced apoptotic neuron death and attenuated the increased in protein levels of active CASPASE 3 in the cortex of diabetic mice.The levels of BCL-2 and BAX were significantly increased in the diabetic animals compared to the controls.Treatment with SCF could significantly attenuated the increase in the expression of BAX but could not affect the level of BCL-2 in the cortex of diabetic mice.P-ERK was significantly decreased in the diabete group but not in dibete plus SCF group.Conclusions SCF can protect a-gainst diabete-induced apoptotic neuron death through increasing the phosphorylation of ERK and influencing the expression of BCL-2/BAX.
8.Recent advances in PLK1 and breast cancer.
Zi-yu LIU ; Yun NIU ; Rong-ju ZHANG
Chinese Journal of Pathology 2011;40(6):427-429
Antineoplastic Agents
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therapeutic use
;
BRCA2 Protein
;
metabolism
;
Breast Neoplasms
;
drug therapy
;
metabolism
;
pathology
;
Cell Cycle Proteins
;
metabolism
;
physiology
;
Centrosome
;
metabolism
;
Drug Screening Assays, Antitumor
;
Female
;
Humans
;
Microtubule-Associated Proteins
;
metabolism
;
Neoplasm Invasiveness
;
Nuclear Proteins
;
metabolism
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Phosphorylation
;
Prognosis
;
Protein-Serine-Threonine Kinases
;
metabolism
;
physiology
;
Proto-Oncogene Proteins
;
metabolism
;
physiology
;
RNA, Small Interfering
;
pharmacology
;
Tumor Suppressor Protein p53
;
metabolism
10.MRI features of mucinous carcinoma of the breast: correlation with histopathology
Peifang LIU ; Lu YIN ; Yun NIU ; Runxian HAO
Chinese Journal of Radiology 2009;43(5):470-475
Objective To characterize the features of breast mucinous carcinoma on T2WI, dynamic contrast-enhanced MR imaging (DCE-MRI) and diffusion weighted imaging (DWI) and correlate the MR features with histopathology. Methods MR imaging in 8 women (aged 33--65 years old) with mncinous carcinoma of the breast verified histopathologically was performed on 1.5 T scanner with T1WI, FS T2 WI, 3D DCE-MRI using volume imaging for breast assessment(VIBRANT) sequence, DWI with b value of 500 and 1000 s/mm2 by single-shot EPI sequence. According to the lexicon of BI-RADS-MRI designed by ACR, the MR findings were retrospectively studied, including morphology, signal intensity on T1WI and FS T2WI, mass enhancement, the patterns of dynamic enhancement curve, and the mean ADC on DWI. The pathologic diagnosis was made according to the standard criteria by the World Health Organization Classification of Tumors. Results Five patients were pure mucinous carcinoma and 3 patients were the mixed. The amount of mucus ranged from 60% to 90%. All 8 tumors presented as a mass on MRI with low signal intensity on T1WI, high or strongly high signal intensity on FS T2WI and high signal on DWI. The tumor size ranged from 1.3 to 3. 2 cm in diameter. Five tumors showed rim enhancement in early phase and the central part was gradually enhanced in delayed phase. One tumor presented slightly heterogeneous enhancement. Two tumors showed progressively heterogeneous enhancement. The mean ADC values of tumor were (2.41±0.28) ×10-3 mm2/s with b value of 500 s/mm2 and (2.06 ±0. 14) × 10-3 mm2/s with b value of 1000 s/mm2, and higher than that of the normal breast tissue [ ( 1.71 ±0. 32) × 10-3 and ( 1.43 ± 0. 24) × 10-3 mm2/s]. Conclusions The MR features of breast mucinous carcinoma on T1WI, DCE-MRI, and DWI are different from that of invasive ductal carcinomas and may reflect its distinct histological type. The combination of these MR sequences may lead to a pre-operative diagnosis of this tumor.