No Abstract Available.
Filtering Surgery* ; Genistein* ; Glaucoma*

No abstract available.
Child* ; Humans ; Tachycardia, Supraventricular*

To access the effects of trabeculectomy or medical treatment on automated visual field progression in glaucoma, a retrospective automated visual field data were obtained for those who underwent six Humphrey C30-2 field tests over at least 4 years. The first field data was excluded. Linear regression was performed with respect to mean deviation[MD], corrected pattern standard deviation[CPSD], and mean thresholds of Glaucoma Hemifield test[GHT]. Subjects were classified as progressive or stable based on the slope and statistical significance. There were 19 persons[25eyes]in surgery group and 16 persons [27eyes]in medication group. The levels of IOP in all subjects were maintained under 21 mms of mercury during all follow-up periods. There was no difference in mean postoperative IOP between both groups[p>0.05]. There were no significant dif-ferences in numbers of aggravation respect to MD, CPSD, and GHT between two groups of surgery and medication[p>0.01]. There was no differnce in the visual field outcome between two groups of surgery and medication with same level of IOP.
Filtering Surgery ; Follow-Up Studies ; Glaucoma ; Humans ; Linear Models ; Retrospective Studies ; Trabeculectomy* ; Visual Fields*

The effect of betaxolol and dipivefrin on microcirculation of peripapil lary reina and optic disc in normal tension glaucoma was assessed. Betaxolol, selective beta-1 blocker, was known to improve the blood flow of retrobulbar arteries, and dipivefrin was known to decrease the flow of ciliary body. Total subjects were 29 normal tension glaucoma patients; 18 subjects with no previous IOP reducing eye drops during 4 weeks were assigned for betaxolol group, and 11 subjects with using timolol for dipivefrin group. The intraocular pressure was significantly reduced after instillation in betaxolol group(p<0.01), and in dipivefrin group(p<0.05). But systemic blood pressure and pulse rate were not changed after instillations in both groups. Blood flow, volume, velocity of optic disc and peripapillary retina of betaxolol group and dipivafrin group were not significantly changed. From the above results, we concluded that betaxolol and dipiverin with timolol did not influenced the microcirculation of peripapillary retina and opit disc.
Arteries ; Betaxolol* ; Blood Pressure ; Ciliary Body ; Heart Rate ; Humans ; Intraocular Pressure ; Low Tension Glaucoma* ; Microcirculation ; Ophthalmic Solutions ; Optic Disk* ; Optic Nerve* ; Retina ; Retinaldehyde* ; Timolol

To determine whether intraocular pressure is overestimated in diabetes with increased corneal thickness. Fifty-four patients with proliferative retinopathy and thirty-six control subjects were included in this study. Corneal thickness was measured by ultrasound pachymetry and intraocular with Goldmann tonometer in all subjects. There were no significant differences in age distribution between control and diabetes mellitus group (59.5 +/-10.4 years versus 60.6 +/-9.5 years). The corneal thickness was greater in patients with diabetes mellitus than in controls (566.8 +/-30.4 micrometerversus 549.9 +/-28.7 micrometer, p<0.05). The intraocular pressure was increased in diabetes mellitus than in controls, too (14.8 +/-2 .6 mmHgversus 13.1 +/-2.7 mmHg,p<0.05). The corneal thickness was correlated with the intraocular pressure (p<0.05). The increased intraocular pressure in diabetes mellitus is associated with increased corneal thickness.
Age Distribution ; Diabetes Mellitus ; Glaucoma ; Humans ; Intraocular Pressure* ; Ultrasonography

Respiratory syncytial virus (RSV) typically causes lower respiratory tract infections in children, and most patients recover successfully. However, some infants and young children can have a severe course of disease with respiratory failure, and extrapulmonary manifestations can occur in severe RSV disease. We report one case of severe RSV bronchiolitis complicated with acute myocarditis, fulminant hepatic failure, and disseminated intravascular coagulation.
Bronchiolitis ; Child ; Disseminated Intravascular Coagulation ; Humans ; Infant ; Liver Failure ; Liver Failure, Acute ; Myocarditis ; Respiratory Insufficiency ; Respiratory Syncytial Viruses* ; Respiratory Tract Infections

Respiratory syncytial virus (RSV) typically causes lower respiratory tract infections in children, and most patients recover successfully. However, some infants and young children can have a severe course of disease with respiratory failure, and extrapulmonary manifestations can occur in severe RSV disease. We report one case of severe RSV bronchiolitis complicated with acute myocarditis, fulminant hepatic failure, and disseminated intravascular coagulation.
Bronchiolitis ; Child ; Disseminated Intravascular Coagulation ; Humans ; Infant ; Liver Failure ; Liver Failure, Acute ; Myocarditis ; Respiratory Insufficiency ; Respiratory Syncytial Viruses* ; Respiratory Tract Infections

To evaluate the validity of FDT as a field analyzer by comparing to Humphrey perimetry with global indeces.FDT is known as a easy to use and convenient device, and there is restriction in pupil size and refractive error within 7 diopters. Forty-two glaucoma patients[79 eyes]were included in this study. All subjects performed FDT N-30 and HFA C30-2 apart 15 minutes on same day.Mean age of subjects were 48.18 +/-16.46years[from sixteen to seventy four years].Twenty-five men and seventeen women were included in this study. Test duration was 4.92 +/-1.08 minutes with FDT N-30 and 13.79 +/-3.32 minutes with HFA C30-2.In global index mean deviation was 14.63 +/-9.52 decibel with HFA C30-2 and 10.33 +/-6 .8 3 decibel with FDT.There was a significant correlation with coefficient correlation 0.940 between two tests[p<0.01]. Pattern standard deviation was 7.89 +/-3 .8 5 decibel in HFA C30-2 and 7.80 +/-3.13 in FDT.There was a significant correlation with coefficient correlation 0.702 between FDT PSD and HFA C30-2 PSD, and 0.691 between FDT PSD and HFA C30-2 CPSD, too[P<0.01].In diagnosing glaucoma, sensitivity and specificity of FDT was 86% and 70% respectively. FDT is thought to be convenient and effective screening tool in glaucoma patients for with a high correlation with HFA C30-2.
Female ; Glaucoma ; Humans ; Male ; Mass Screening ; Pupil ; Refractive Errors ; Sensitivity and Specificity ; Visual Field Tests ; Visual Fields

PURPOSE: The clinical characteristics and neuropsychological tests of orthostatic hypotension (OH) and postural orthostatic tachycardia syndrome (POTS) in children were compared. METHODS: From August 2011 to April 2015, we enrolled patients who visited hospital with dizziness or syncope. According to the results of head-up tilt test (HUTT), the patients were classified into 4 groups; OH group, POTS group, normal group I who had no orthostatic symptom during HUTT, and normal group II who had orthostatic symptom during HUTT. RESULTS: Eighty-eight patients were enrolled with 11(12.5%) in OH group, 13(14.7%) in POTS group, 49(55.7%) in normal group I and 15(17.0%) in the normal group II. During HUTT, the temporal changes of systolic, diastolic, and mean blood pressure of OH group were significantly different from those of POTS group, normal group I, and normal group II. Heart rate changes after tilt showed increase trend in all 4 groups and there was no significant different between OH and POTS group. In normal group II, the temporal changes of diastolic and mean blood pressure were similar to those in POTS group and were significantly different from normal group I. In the autonomic nervous system test, the heart rate response to deep breathing (HRDB) was significantly different between normal group I and II CONCLUSIONS: In pediatric OH patients, heart rate may be increased with blood pressure fall. And if orthostatic symptoms are associated with HUTT, we should not exclude OI even if the test result do not meet the criteria for diagnosis.
Autonomic Nervous System ; Blood Pressure ; Child* ; Diagnosis ; Dizziness ; Heart Rate ; Humans ; Hypotension, Orthostatic* ; Neurophysiology* ; Neuropsychological Tests ; Postural Orthostatic Tachycardia Syndrome* ; Respiration ; Syncope

Failure of glaucoma filtering surgery most commonly results from excessive fibrosis and occlusion of the filtration site. Many drugs have been investigated to improve surgical results, but drugs that effectively suppress fibroblast activity with less side effects have not been found yet. Genistein, an isoflavonoid phytoestrogen found in soya bean and other legumes, has been reported as a potent inhibitor of tyrosine kinase and suppresses the receptor activation of many growth factors. In this study, the effect of genistein on the proliferation of subconjunctival fibroblast in rabbits were investigated. Cell proliferation was assayed after bFGF (10ng/ml), TGF-beta1 (10ng/ml), EGF (5ng /ml), PDGF (20ng/ml) in cultured rabbit fibroblasts and the effects of genistein on them were analyzed. Each growth factors stimulated fibroblast proliferation effectively. bFGF, TGF-beta1, EGF and PDGF stimulated cell growth by 183%, 163%, 134%, and 182% after 24 hours, respect- ively, and cell growths were increased up to 72 hours. Genistein 50 micrometer suppressed stimulated fibroblast growth by 36%, 46%, 65% and 43%in bFGF, TGF-beta1, EGF and PDGF stimulated samples 24 hours later respectively. Therefore, we speculate that genistein suppresses the proliferating activity of growth factor-induced fibroblasts in rabbit.
Blister ; Cell Proliferation ; Epidermal Growth Factor ; Fabaceae ; Fibroblasts* ; Fibrosis ; Filtering Surgery ; Filtration ; Genistein* ; Glaucoma ; Intercellular Signaling Peptides and Proteins ; Intraocular Pressure ; Phytoestrogens ; Protein-Tyrosine Kinases ; Rabbits ; Transforming Growth Factor beta1