No abstract available.
Arrhythmias, Cardiac* ; Child* ; Humans

No abstract available.
Multiple Organ Failure* ; Sepsis*

Evaluation of a fever of unknown origin (FUO) is complex. Recently, PET scanning has been approved for screening in FUO evaluation. We treated three cases of FUO associated with increased FDG uptake in the bone marrow of the femur and tibia on the fusion PET/CT; all three had the same pattern of uptake. Bone marrow biopsies revealed mature lymphocyte and histiocyte infiltration and myxoid changes in one case, and cortical bone involvement in another case. The cases were all young females who had fever with neutropenia and relative lymphocytosis that lasted for several weeks and then remitted spontaneously. Even though the results of the studies were not diagnostic, the unique uptake pattern on PET/CT and the histology might be related to the cause of the illness and should be studied further to assess the association with classic FUO.
Biopsy ; Bone Marrow ; Female ; Femur ; Fever ; Fever of Unknown Origin ; Histiocytes ; Humans ; Lymphocytes ; Lymphocytosis ; Mass Screening ; Neutropenia ; Positron-Emission Tomography ; Tibia

No abstract available.
Thoracic Outlet Syndrome*

No abstract available.
Amiodarone* ; Arrhythmias, Cardiac* ; Child* ; Humans

BACKGROUND/AIMS: The caudal anesthsia is most commonly used for benign anorectal surgery, The combination of long-acting anesthetics and opiates has been used for longer duration and successful control of postoperative pain. But the side effects of peridural anesthesics and morphine have commonly occured in caudal anesthesia. This study was performed to assess the difference in clinical effects between peridural mepivacaine and bupivacaine with morphine. METHODS: We evaluated the clinical effects in 60 patients who had anal operation with Jack-Knife position under caudal anesthesia. We divided randomly these 60 patients into two groups, M and B groups (in each group, 30 patients included). Group M (n=30) was given 2% mepivacaine 20 ml with morphine 2 mg caudally, and Group B (n=30) was given 0.5% bupivacaine 20 ml with morphine 2 mg in the same manner. We measured the onset time, duration, postoperative analgesia, and side effects including urinary retention. RESULTS: The onset time for analgesia was significantly shorter in group M than in group B. The duration of postoperative pain complaints was significantly longer in group M than in group B. The postoperative analgesic effects and side effects were not significantly different between two groups. CONCLUSIONS: Caudal mepivacaine and morphine mixture is effective for control of postoperative pain without significant side effects.
Analgesia ; Anesthesia, Caudal* ; Anesthetics ; Bupivacaine* ; Humans ; Mepivacaine* ; Morphine* ; Pain, Postoperative ; Urinary Retention

No abstract available.
Sepsis*

We have used BALB/c mice as an animal model for the study of anaphylactic hypersensitivity to the house dust mite. For the sensitization, BALB/c mice were injected with a single dose of extracts of Oermatophagoides farinae (D. pa) or Dermatophagoides pteronyssinus (D. pt) mixed with adjuvants (aluminum hydroxide and Bordetella pertussis) intraperitonealy. On days of 15, 30, and 60 after the sensitization, the mice received a challenge dose of the same allergen intravenously to induce anaphylactic shock. The hypersensitivity reactions were scored by anaphylactic shock. And various immunological parameters, including cytokines and immunoglobulin isotypes, were studied in relation with the shock. A high level of anaphylactic shock was produced in the mice by both of the allergens, D, fa and D, pt, at 15 and 30 days after sensitization. In vitro Ag specific proliferative reponses of spleen cells from D. pt treated mice (D. pt mice) was six times higher than those from O. fa treated mice (O. fa mice). Regardless the differences in antigens, the production of IFN-r by spleen cells from D. pt mice or O. fa mice was equally high at 15 days after sensitization. However, the ability to produce IFN-r by the spleen cells from D, pt mice was three times higher compared to that from D. fa mice. The production of IL-4 by the spleen cells was enhanced slightly but not significant in both groups. In studies of the allergen-specific immunoglobulin isotypes in the sera of the mice, the level of IgE in both groups was enhanced slightly but not significant. In contrast, the level of IgG subtypes were increased in both groups. When the levels of IgG were compared by subtypes, the level of IgG1 increased significantly on day 15 when the anaphylactic shock score was maximized in both groups. Increase in IgG2a level at the day was not significant, instead, asignificant increase in IgG2 levels was observed on day 60 after sensitization when the anaphylaxis was almost discontinued. Although a higher level of IgG3 was examined on day 15 and 30 in D. pt mice and on day 60 in D, fa mice, anaphylaxis was not appeared to be associated with the levels of IgG3 in this study. The IgG1, rather than IgE, was assumed to the major factor involved in the anaphylactic response observed in this experiment. In conclusion, BALB/c mice would be an animal model for the study of anaphylactic hypersensitivity to D. fa or D, pt., which might be an essential tool for the future development of immuno-therapeutic agents.
Mice ; Animals

Trichofolliculoma is an adnexal tumor of hair follicle oriyin, considered to be of intermediate differentiation between a hair follicle nevus, a simple hyperolasia of the hair follicle, and trichoepithelioma, Which usually lacks mature hair follicles. Grossly the tumor usually appears on the head or neck as a 0.5 to 1.0cm solitary white to pearly papule, Many lesions show a cental pore, and occasionally woolly or cottony hairs may protrude from this pore. Histologically, trichofolliculomas are characterized by a central dilated follicle filled with keratin or hair. Radiating from this primary hair follicle are numerous secndary hair follicles of varying degrees of maturation. An organized fibro-vascular stroma surrounds these epithelial structure, giving it a well-defined nodular appearance. We presented here two case of trichofolliculoma with typical clnical and histopathological findings, one in a 65 year-old female and the other a 56 year-old males.
Aged ; Female ; Hair ; Hair Follicle ; Head ; Humans ; Male ; Middle Aged ; Neck ; Nevus

Trichofolliculoma is an adnexal tumor of hair follicle oriyin, considered to be of intermediate differentiation between a hair follicle nevus, a simple hyperolasia of the hair follicle, and trichoepithelioma, Which usually lacks mature hair follicles. Grossly the tumor usually appears on the head or neck as a 0.5 to 1.0cm solitary white to pearly papule, Many lesions show a cental pore, and occasionally woolly or cottony hairs may protrude from this pore. Histologically, trichofolliculomas are characterized by a central dilated follicle filled with keratin or hair. Radiating from this primary hair follicle are numerous secndary hair follicles of varying degrees of maturation. An organized fibro-vascular stroma surrounds these epithelial structure, giving it a well-defined nodular appearance. We presented here two case of trichofolliculoma with typical clnical and histopathological findings, one in a 65 year-old female and the other a 56 year-old males.
Aged ; Female ; Hair ; Hair Follicle ; Head ; Humans ; Male ; Middle Aged ; Neck ; Nevus