1.Analysis of C-kit expression in acute leukemic cells(1).
Yoo Hong MIN ; Gil Jin JANG ; Sun Yung RA ; Sun Ju LEE ; Jee Sook HAHN ; Yun Woong KO
Korean Journal of Hematology 1993;28(2):267-277
No abstract available.
2.Cervical Radiculopathy: Selective Nerve Root Injection of Steroids.
Duk Hyun SUNG ; Kang Woo LEE ; Yun Ju RA
Journal of the Korean Academy of Rehabilitation Medicine 2000;24(4):725-732
OBJECTIVE: To determine the therapeutic efficacy of fluoroscopic and electrical stimulation guided perineural selective nerve root injection in cervical radiculopathy patients. METHOD: The gold standard of the diagnosis of cervical radiculopathy was based on clinical features, MRI and electrodiagnostic findings. Considering the natural regression of pain in cervical radiculopathy, only patients (n=27, 14 male and 13 female) who had suffered from persisting or aggravating pain for at least 6 weeks or longer duration after the onset of symptoms, were received a selective nerve root injection (SNRI) of steroids to a target nerve root. Patients were followed up at 2 weeks and 2 months, and interviewed via telephone or re-examined at an average of 37.8 weeks 68 weeks after injection by a independent physician. Criteria for a successful outcome were greater than 50% reduction of pain on visual analogue scale and an ability to return to previous level of function. RESULTS: High proportion of patients reported a successful outcome at 2 weeks (88.9%, 24 of 27 patients). Twenty-two of twenty-four patients reported the outcome at 2 months and 20 of 22 patients were followed up for an averrge period of 37.3 weeks. Among these 20 patients 19 patients satisfied with the result of SNRI at an average follow up period of 68 weeks. There was no significant difference of the efficacy according to the duration of the symptoms. There were no complications in any of the patients after injections. CONCLUSION: Fluoroscopic and electrical stimulation guided selective nerve root injections of corticosteroids were an effective and safe treatment modality in cervical radiculopathy. These could be considered as a first line treatment before a surgical intervention in whom another conservative treatments are not effective.
Adrenal Cortex Hormones
;
Diagnosis
;
Electric Stimulation
;
Follow-Up Studies
;
Humans
;
Magnetic Resonance Imaging
;
Male
;
Radiculopathy*
;
Steroids*
;
Telephone
3.Estimation of Reference Values of Median Nerve Conduction Study: A Meta-Analysis.
Journal of the Korean Academy of Rehabilitation Medicine 2002;26(6):717-727
OBJECTIVE: The comparison of nerve conduction parameters of each laboratory is difficult because those are influenced by many factors. This study was performed to provide comprehensive normative nerve conduction parameters of median nerve by using a meta-analysis. METHOD: We searched MEDLINE between year 1965 to 2000. Among them we selected 7 articles that provided the mean, standard deviation and sample size of median nerve conduction study and estimated the reference value of median nerve conduction parameters using a meta-analysis. RESULTS: The distal latency of median motor nerve was measured at 8 cm proximal to motor point of abductor pollicis brevis and the distal latency of median sensory nerve was measured at 14 cm proximal to interphalangeal joint of 2nd or 3rd finger. Mean of distal onset latency, amplitude, and conduction velocities of median motor nerve were 3.46 msec, 11.12 mV, and 57.10 m/sec, respectively. Mean of onset distal latency, peak distal latency, and amplitude of median sensory nerve conduction study were 2.72 msec, 3.34 msec, and 37.29 mV, respectively. CONCLUSION: Meta-analysis can summarize large quantity of studies and can maximize subject numbers, it can provide reference value approximate to the normal one. So this value can be used in interpretation of the reference value of each laboratories.
Fingers
;
Joints
;
Median Nerve*
;
Neural Conduction
;
Reference Values*
;
Sample Size
4.Partial trisomy of chromosome 18q11.2-q12: A case report.
Ah Ra CHO ; Hye Ryoun KIM ; Mi Kyung LEE ; Sin Weon YUN ; Jung Ju LEE
Korean Journal of Pediatrics 2009;52(10):1171-1174
Edwards syndrome, also called trisomy 18, is one of the most common autosomal anomalies. The survival rate of patients with Edwards syndrome is very low and its characteristic findings include cardiac malformations, mental retardation, growth retardation, specific craniofacial anomalies, clenched hands, rocker-bottom feet, and omphalocele. Compared with the classic Edwards syndrome, the symptom of partial duplication of chromosome 18 is relatively mild with a good prognosis. We report the case of a baby with partial duplication 18q11.2-q12. The characteristic phenotype features of Edwards syndrome were observed in the patient. However, the symptom was milder than the typical Edwards syndrome. At present, we can expect better prognosis for this patient.
Chromosomes, Human, Pair 18
;
Foot
;
Hand
;
Hernia, Umbilical
;
Humans
;
Intellectual Disability
;
Phenotype
;
Prognosis
;
Survival Rate
;
Trisomy
5.Diabetic Muscle Infarction in Diabetes; Three cases report.
Ji Hye HWANG ; Soon Tak JEONG ; Yun Ju RA ; June Yong JUNG
Journal of the Korean Academy of Rehabilitation Medicine 2003;27(5):803-807
Spontaneous muscle infarction in diabetic patients is a rare condition that usually occurs in those with advanced diabetic complications. Increased clinical awareness is important for early recognition, particularly in a diabetic patient presenting with a painful thigh or leg swelling. However, the disorder has received little attention in the rehabilitation medicine literature. Magnetic resonance imaging is the diagnostic choice of study, and in the appropriate clinical setting, may obviate the need for a muscle biopsy. We reported three patients with diabetic muscle infarction, review additional reported cases, and discussed the principles of diagnosis and management.
Biopsy
;
Diabetes Complications
;
Diabetes Mellitus
;
Diagnosis
;
Humans
;
Infarction*
;
Leg
;
Magnetic Resonance Imaging
;
Rehabilitation
;
Thigh
6.Value of N-terminal pro-Brain Natriuretic Peptide in Acute Stage of Ischemic Stroke.
Yun Ju CHOI ; Seung Han LEE ; Kang Ho CHOI ; Kee Ra LEE ; Seong Min CHOI ; Man Seok PARK ; Byeong Chae KIM ; Myeong Kyu KIM ; Ki Hyun CHO
Journal of the Korean Neurological Association 2007;25(4):508-514
BACKGROUND: Brain natriuretic peptide (BNP) is expected to play a role in hemodynamic modulation. Its biologically inactive fragment, the 76-amino-acid N-terminal proBNP (NT-pro-BNP), was known as one of the biologic markers of congestive heart failure and other clinical situations. But, there are controversies about clinical significance of NT-pro-BNP in ischemic stroke. This study was performed to find the clinical significance of NT- pro-BNP in early stage of acute ischemic stroke. METHODS: NT-pro-BNP levels were measured in 610 consecutive patients who admitted to the department of neurology at Chonnam National University Hospital. 205 patients were excluded due to incomplete follow-up period (more than 2 weeks), systemic infection, and etc. 286 ischemic stroke patients and 119 patients as control subjects were enrolled. NT-pro-BNP levels between stroke group and control were analyzed. When the patients in stroke group had more than 300 pg/mL of NT-pro-BNP, they were regarded as high group and the others were low group. National Institute of Health Stroke Scale (NIHSS) was checked at admission and 2 weeks later. Relationship between changes of NIHSS and the NT-pro-BNP level was also investigated. RESULTS: The NT-pro-BNP levels were significantly increased in ischemic stroke patients (830.87 pg/mL) compared with control group (378.27 pg/mL) (p=0.002). And the high levels of NT-pro-BNP in stroke patients were related to severity on admission and cardioembolic infarction. But there was no correlation between NT-pro-BNP and improvement of NIHSS. CONCLUSIONS: In this study, significant relationship between the severity of ischemic stroke and NT-pro-BNP was found. But NT-pro-BNP was not related to early prognosis of ischemic stroke.
Biomarkers
;
Follow-Up Studies
;
Heart Failure
;
Hemodynamics
;
Humans
;
Infarction
;
Jeollanam-do
;
Natriuretic Peptide, Brain
;
Neurology
;
Prognosis
;
Stroke*
7.Prominent Crista Terminalis in Patients with Embolic Events.
Jin Oh NA ; Eung Ju KIM ; Sun Joung MUN ; Eun Hee CHOI ; Jin Hee MUN ; Hye Ra LEE ; Yun Kyung KIM ; Hwan Seok YONG
Journal of Cardiovascular Ultrasound 2011;19(3):156-158
A prominent crista terminalis is a normal anatomic variant which consist of thick muscular bridge within the right atrium. However, it could be often misdiagnosed with an abnormal mass on the transthoracic echocardiography. The case report presented here, describe the findings of transthoracic echocardiography that suggested a right atrial mass in patients with pulmonary embolism. However, subsequent transesophageal echocardiography and cardiac computed tomography/magnetic resonance imaging differentiated a true right atrial mass from a prominent crista terminalis.
Echocardiography
;
Echocardiography, Transesophageal
;
Heart Atria
;
Humans
;
Pulmonary Embolism
8.Localization of Klotho in cisplatin induced acute kidney failure.
So Ra PARK ; Tae Won KIM ; Young Jung KIM ; Hyun Tae KIM ; Si Yun RYU ; Ju Young JUNG
Korean Journal of Veterinary Research 2014;54(4):225-231
Klotho deficiency is an early event in acute kidney injury (AKI) that exacerbates acute kidney damage. The present study explored the expression of Klotho and inflammation related factors in cisplatin-induced AKI. Rats (n = 18) were treated with cisplatin intraperitoneal injection (5 mg/kg) or left untreated as controls (n = 6), then sacrificed at 5 (n = 6) and 10 days (n = 6) treatment. Five days after cisplatin injection, the serum kidney enzymes and kidney cell apoptosis were significantly increased. Moreover, the expression of Klotho was decreased when compared to the control group, especially in the cortex and outer medulla regions. In contrast, inflammation related signals including nuclear factor kappa B, tumor necrosis factor-alpha, and tumor necrosis factor-like weak inducer of apoptosis were enhanced. However, 10 days after cisplatin injection, Klotho expression was enhanced upon both IHC and Western blot analysis, with slightly recovered renal function and decreased apoptosis. Furthermore, inflammation related signals expression was decreased relative to the 5 days group. Overall, this study confirmed the opposite expression patterns between Klotho and inflammation related signals and their localization in cisplatin-induced AKI kidney.
Acute Kidney Injury*
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Animals
;
Apoptosis
;
Blotting, Western
;
Cisplatin*
;
Inflammation
;
Injections, Intraperitoneal
;
Kidney
;
Necrosis
;
NF-kappa B
;
Rats
;
Tumor Necrosis Factor-alpha
9.Three Cases of Spontaneous Muscle Hematoma in Alcoholic Liver Cirrhosis.
Dong Hoon LEW ; Ja Yoon CHOI ; Ra Ri CHA ; Hye Won OH ; Yun Won JO ; Hyun Ju MIN ; Ok Jae LEE
Korean Journal of Medicine 2014;86(4):472-477
Liver cirrhosis is commonly associated with bleeding complications due to portal hypertension or coagulopathy. Spontaneous muscle hematoma is a rare but potentially lethal complication of liver cirrhosis. Here we report three cases of spontaneous muscle hematoma diagnosed in patients with alcoholic liver cirrhosis. All three patients died due to recurrent bleeding and liver failure although they had undergone repeated transcatheter arterial embolization of the actively bleeding vessels. We reviewed 14 cases of spontaneous muscle hematoma that were associated with liver cirrhosis, including our cases, and found that the mortality rate was 86%, despite early diagnosis and treatment. Cirrhosis-associated spontaneous muscle hematoma occurred more frequently in patients with alcoholic liver cirrhosis, who accounted for -93% of cases. Thus, spontaneous muscle hematoma should be considered a life-threatening complication in patients with alcoholic liver cirrhosis, and abstinence from alcohol may help to prevent the occurrence of this deadly condition.
Alcoholics*
;
Early Diagnosis
;
Fibrosis
;
Hematoma*
;
Hemorrhage
;
Humans
;
Hypertension, Portal
;
Liver Cirrhosis
;
Liver Cirrhosis, Alcoholic*
;
Liver Failure
;
Mortality
10.Subclinical Pseudohypoparathyroidism with Recurrent Seizure in Postpartal Period.
Yun Ju CHOI ; Kang Ho CHOI ; Kee Ra LEE ; Seong Min CHOI ; Seung Han LEE ; Man Seok PARK ; Byeong Chae KIM ; Myeong Kyu KIM ; Ki Hyun CHO
Journal of the Korean Neurological Association 2007;25(3):383-385
Pseudohypoparathyroidism (PHP) is a disorder characterized by clinical and laboratorial findings of hypoparathyroidism with high plasma parathyroid hormone levels due to resistance by target tissues. Neurologic complications of PHP are not uncommon but recurrent attacks of seizure during the postpartal period have yet to be reported. We report a case of subclinical pseudohypoparathyroidism with recurrent seizures in the postpartal period.
Hypoparathyroidism
;
Parathyroid Hormone
;
Plasma
;
Postpartum Period
;
Pseudohypoparathyroidism*
;
Seizures*