Lung transplantation has been successfully employed for variety of obstructive lung disease. Single lung transplantation has become a therapeutic option for end-stage obstructive lung disease. The patient, a 57 year old man with emphysema, suffered from severe dyspnea, which progressively aggravated him for the last three years. A single lung transplantation was performed from a young brain-dead donor on April 7th, 1999 in the department of thoracic surgery, Respiratory Center, Yongdong Severance hospital, yonsei University. The immunosuppressive regimen was based on cyclosporine A and azathioprine from beginning, adding steroid. Single lung transplantation was feasible and beneficial in patients with end-stage emphysema.
Azathioprine ; Cyclosporine ; Dyspnea ; Emphysema ; Humans ; Lung Diseases, Obstructive ; Lung Transplantation* ; Lung* ; Middle Aged ; Pulmonary Emphysema* ; Respiratory Center ; Thoracic Surgery ; Tissue Donors

No abstract available.
Erythrocyte Membrane* ; Erythrocytes* ; Hydroxyl Radical* ; Lipid Peroxidation* ; Macrophages, Alveolar* ; Mineral Fibers*

No abstract available.
Angiofibroma*

OBJECTIVE: To evaluate the clinical efficacy of a new air cleaning device (LG Electronics, Korea) equipped with electrostatic precipitator (EP) and photocatalytic plasma filter (PCP) in 24 respiratory allergic subjects. MATERIAL AND METHOD: Air cleaning conditioner and air cleaner were placed in living room and bedroom. Both EP and PCP (EP/PCP) filters were used for the first 4 weeks and for another 4 weeks, PCP without EP filter (PCP) was used. We measured symptom scores of asthma and rhinitis, peak expiratory flow rate (PEFR), serum eosinophil cataionic prote in? in ECP, Dermatophagoides farinae (DF) specific IgE and IgG in sera, concentrations of major allergens of DF in floor dust of living room, bedroom and in airborne dust. RESULTS: Both asthma and rhinitis symptom scores were significantly improved not only with EP/PCP filters but also with PCP filter. The morning PEFR was significantly improved with EP/PCP filters, but not with PCP filter. Frequency of salbutamol inhalation by air cleaner with EP/PCP filter tended to de crease(p=0.051), with no significant difference in serum ECP concentration. DF specific IgE significantly decreased at the 8th week with no differences in specific IgG. However, the mean Der f I levels in floor dust of bedroom (1, 128 vs. 374 ng/gm dust, p<0.01) and living room (1,516 vs 812 ng/gm dust, p<0.01) decreased, Der f1 in airborne dust measured only in 8 out of 22 subjects, and they decreased significantly with the trial of EP/PCP filter (172.2 pg/4.5m vs. 62.1 pg/4.5m, p<0.01). CONCLUSION: These results suggest that the EP/PCP air cleaner may be an effective tool for environmental control in respiratory allergic subjects.
Albuterol ; Allergens ; Asthma ; Dermatophagoides farinae ; Dust ; Eosinophils ; Humans ; Immunoglobulin E ; Immunoglobulin G ; Inhalation ; Peak Expiratory Flow Rate ; Plasma* ; Rhinitis

Lung transplantation in the treatment of end-stage emphysema has been increasing in number since the recent rise in the 5 year survival rate. For the shortage of donor lungs, the single lung transplantation or transplantation in ABO compatible, nonidentical recipients has also been increasing. The lung transplantation in compatible, nonidentical recipients show good results as with identical recipients with the proper application of immunosuppressive agents. We transplanted the left lung of a 41 year-old male donor to a 35 year-old female recipient who had been suffering from severe dyspnea due to end-stage emphysema. For postoperative immunosuppression, we applied conventional triple immunotherapy(cyclosporine, azathioprine, prednisolone) and we could suppress the rejection response of transplanted lung by adding the anti-CD3 antibody(OKT3) during the operation. The patient could be discharged without any specific problem at 18th postoperative day.
Adult ; Azathioprine ; Dyspnea ; Emphysema ; Female ; Humans ; Immunosuppression ; Immunosuppressive Agents ; Lung Transplantation* ; Lung* ; Male ; Survival Rate ; Tissue Donors

BACKGROUND: We studied the quality of life (QOL) of patients with restless legs syndrome (RLS) and compared it to that of normal controls and patients with hypertension or diabetes in Korea. METHODS: We developed a Korean version of the Johns Hopkins RLS QOL questionnaire by translating this into Korean and then back into English to check its accuracy. In total, 250 RLS patients were included in this study. The scores of RLS patients were compared with those of 215 normal controls, 196 patients with hypertension, and 185 diabetics. All subjects completed the questionnaires, including the Korean versions of the Short Form 36, Johns Hopkins RLS QOL, Pittsburgh Sleep Quality Index, and the Beck Depression Inventory. The associations between the severity of RLS and the QOL scores were examined using Pearson correlations. RESULTS: The QOL scores were lower in subjects with RLS than in the normal controls and the patients with hypertension or diabetes. More severe RLS symptoms were associated with a lower QOL score. Correlation analysis revealed a significant negative correlation between the severity of RLS symptoms and QOL score (r=-0.702, p<0.001). However, neither the gender of the RLS subjects nor the age at symptom onset (early or late onset) affected the QOL score. The factors most related to QOL score in RLS patients were depression and sleep quality. CONCLUSIONS: We found that Koreans with RLS have a considerably diminished QOL, with this being worse than in Korean subjects with diabetes or hypertension. These findings are comparable with studies conducted in Western countries.
Chronic Disease ; Depression ; Humans ; Hypertension ; Korea ; Quality of Life ; Surveys and Questionnaires ; Restless Legs Syndrome ; Sleep Wake Disorders ; Translating

No abstract available.
Humans ; Survival Rate*

In 1938, Jarcho and Levin initially described shortening of the trunk, prominent occiput, broad forehead, multiple vertebral defects and ribs anomaly, short neck, increased anteroposterior chest diameter, lordosis, kyphoscoliosis. After that, Jarcho-Levin syndrome is an eponym that has been used to describe a variety of clinical phenotypes. We examined a girl who was suspected as suffering from Jarcho-Levin syndrome because she had shortening of the trunk, multiple vertebral defects and ribs anomaly, short neck, increased anteroposterior chest diameter, lordosis, kyphoscoliosis. We report a case of Jarcho-Levin syndrome with intrathoracic kidney, and review related literature.
Animals ; Eponyms ; Female ; Forehead ; Humans ; Kidney* ; Lordosis ; Neck ; Phenotype ; Ribs ; Thorax

BACKGROUND: Recently, the diagnosis of non-alcoholic fatty liver disease (NAFLD) has been made more frequently, as the use of ultrasonography on health screening has been on the rise. The aim of this study was to elucidate the relationship between NAFLD and the metabolic syndrome defined by NCEP-ATP III criteria. METHODS: A total of 1,675 subjects, who attended for routine physical check?ups, were screened. Among those, 401 subjects were selected after excluding the subjects with either significant alcohol consumption, evidence of viral or toxic hepatitis, significant liver or renal dysfunction, or overt thyroid disease. NAFLD was diagnosed if the subjects had a "bright liver" on ultrasonographic examination. The diagnosis of metabolic syndrome was made according to the criteria of NCEP-ATP III established in 2001. RESULTS: The prevalence of NAFLD was 27.2%. Blood pressure, body weight, body mass index, waist circumference, and serum levels of total cholesterol, triglyceride, fasting glucose and liver enzymes were higher among the subjects with NAFLD than the control. The prevalence of obesity, IFG/DM, dyslipidemia and hypertension was higher in the NAFLD group. The prevalence of the metabolic syndrome was 19.2%, which was higher in the NAFLD group than the control group. The odds ratio of NAFLD for the metabolic syndrome was 6.458 (95% C.I. 3.178~13.124). CONCLUSION: NAFLD was closely associated with the metabolic syndrome regardless of the presence of obesity.
Alcohol Drinking ; Blood Pressure ; Body Mass Index ; Body Weight ; Cholesterol ; Diagnosis ; Drug-Induced Liver Injury ; Dyslipidemias ; Fasting ; Fatty Liver* ; Glucose ; Hypertension ; Liver ; Mass Screening ; Obesity ; Odds Ratio ; Prevalence ; Thyroid Diseases ; Triglycerides ; Ultrasonography ; Waist Circumference

PURPOSE: To decide diagnostic titer in a single determination of antibody by indirect particle agglutination test and to characterize the occurrence of Mycoplasma pneumoniae during a 9 year-period in Seoul. METHODS: M. pneumoniae pneumonia diagnosed serologically at the Seoul National University Children's Hospital from 1986 to 1995 were reviewed, retrospectively. Antimycoplasma antibody was measured by indirect particle agglutination test. Diagnosis was based on 4 fold-rise or single high titer. Single diagnostic titer was set up by the value greater than the 90th percentile of the titer at one year of the children who initially had 4 fold-rise or > or =160. RESULTS: The geometric mean titer and the 90th percentile at 1 year of the 15 children who initially had antibody titer > or =160 or 4 fold-rise were 122 and 639, respectively, and single diagnostic titer was established as > or =640. A total of 126 childern were included by our diagnostic criteria. Male and female ratio was 1.17:1 and the mean age was 6 years 4 months. Pneumonia by M. pneumonuae occurred every years during the study period showing increased cases every 3 years. In the epidemic years, the cases occurred in late spring, summer and early fall. CONCLUSIONS: It is concluded that the occurrence of Mycoplasma pneumoniae pneumonia in Seoul from 1986 to 1995 was characterized by epidemics every 3 years as well as its endemicity.
Agglutination Tests ; Child ; Diagnosis ; Epidemiology ; Female ; Humans ; Korea* ; Male ; Mycoplasma pneumoniae* ; Mycoplasma* ; Pneumonia* ; Pneumonia, Mycoplasma* ; Retrospective Studies ; Seoul*