Majolin's ulcer is a carcinomatous ulcer from degenerating burn scars. This patient is a 44 year-old man who has been suffering from pain and itching sensation on Rt. wrist of burn scars. Symptom has been developed since 18 months ago. Skin lesion is a well defined, slight brownish colored, scaly verrucous surfared plaque with reddish ringlike border and oozing tendency in small part. On physical examination, he is in within normal limit excepet burn scar on Rt. upper extremity. He was received burn with gasolin at the age of seven. Biopsy on the skin lesion revealed well differentiated squamous cell carcinoma appearance. Diagnosis was confirmed by the history and histopathological finding. Literature was briefly reviewed.
Adult ; Biopsy ; Burns ; Carcinoma, Squamous Cell ; Cicatrix ; Diagnosis ; Humans ; Physical Examination ; Pruritus ; Sensation ; Skin ; Ulcer* ; Upper Extremity ; Wrist

No abstract available.
Cushing Syndrome*

No abstract available.

Adequate growth is the most importment and principal factor in the fields of pediatrics and also it is great concern to all parents. There are many causes of short stature, secondary to a variety of causes. Clinical evaluation of short stature requires a wide variety of clinical, radiographic, pathologic, and biochemical tools. The most important thing is early and accurate diagnosis of disease. As a first step to do so, we performed the clinical analysis of 25 short statured children who had been admitted to Severance Hospital in recent 10 years. Results were as follows; 1) In 25 cases, male were 11 and female were 14 cases. Etiologically, contitutional slow growth 2, mongolism 1, gargoylism 3, achondroplasia 3, spondylometaphyseal dsplasia 1, cretinism 12, and pitutary dwarfism 3 cases.2) Chronological age at the beginning of diagnostic approach were generally delayed. 3) Height age and bone age of dwarfism were markedly retarded than chronological age wheras weight age showed no specific relationship except in case of malnutrition. 4) skeletal dysplasia and endocrine dwarfism, bone age was retarded than height age. But in constitutional slow growth, discrepancy was not marked. 5) Head circumference in each type of short stature was variable. 6) Diagnostic methods include measurement of height and bone age, X-ray, thyroid function test, growth hormone stimulation test and chromosome study.
Achondroplasia ; Child ; Congenital Hypothyroidism ; Diagnosis ; Down Syndrome ; Dwarfism ; Female ; Growth Hormone ; Head ; Humans ; Male ; Malnutrition ; Mucopolysaccharidosis I ; Parents ; Pediatrics ; Thyroid Function Tests

BACKGROUND: An aortocaval compression by the gravid uterus in late pregnancy leads to acute hypotension in the mother and decreases uteroplacental blood flow which may affect neonatal outcome. The purpose of this study was to evaluate maternal hemodynamic changes, which affect neonatal outcome under general anesthesia for an elective cesarean section depending on the maternal position-supine or left lateral 15degrees tilting by wedge. METHODS: Forty women undergoing an elective cesarean section under general anesthesia delivered through the supine position or left lateral 15degrees tilting by wedge position randomly. The maternal brachial blood pressure and heart rate were recorded, and the maternal arterial blood, umbilical artery and vein blood were sampled. Induction-to-delivery time (IDT), uterine incision-to-delivery time (UDT), and Apgar scores were measured. RESULTS: The two groups had no maternal hypotension less than 100 mmHg, and there were no significant differences in brachial blood pressure and heart rate of the mother, or acid-base status and Apgar scores of the neonate. CONCLUSIONS: In conclusion, maternal position had no clinical significant effects on maternal brachial blood pressure and heart rate, and neonatal outcome.
Anesthesia, General ; Blood Pressure ; Cesarean Section ; Female ; Heart Rate ; Hemodynamics ; Humans ; Hypotension ; Infant, Newborn* ; Mothers ; Pregnancy ; Supine Position ; Umbilical Arteries ; Uterus ; Veins

No abstract available.
Pulmonary Artery*

Functional recovery after mandibular condyle fracture was a contradictory result of many authors. The treatment goal of condyle fracture has been directed primarily toward restoration of functional movement of the mandible. We selected some patients who requested functional therapy in many cases of condylar fracture, depend on pattern of fracture, patient's demand, occlusion, age. Without intermaxillary fixation, we induced the patients to rapid healing of temporomandibular function and normal mandibular protrusive, lateral movement as a result of early functional therapy by activator. So, the authors report the cases with review of concerned literature.
Humans ; Mandible ; Mandibular Condyle

1.050 patients who visited orthodontic dental department from 1983 to 1994, were surveyed on the yearly tendency of orthodontic patient distribution and state by means of Angle's classification. The results were as follows : 1. There was increased visiting rate of patient per year and higher visiting rate in female than in male. 2. 8-15 age group was 61.4% in total visiting patients and over 20 age group was 18.5%, under 7 age group was 8.1%. 3. Class I malocclusion was 42.2%, class II div 1 was 22.5%, class II-2 was 3.9%, class III was 29.1% and cleft lip & palate was 2.0% in total visiting patient. 4. As showed the living distribution, Namgu and Susunggu's patients were 43.7% of the total patients. 5. There was increased tendency for the number of the patient to be received orthognathic surgery.
Cleft Lip ; Dentistry* ; Female ; Humans ; Male ; Malocclusion* ; Orthodontics* ; Orthognathic Surgery ; Palate

We present 3 cases of congenital hyperplasia. Case lis a 5 year and 9 month old who is suffered from excessive salt craving and symptoms of precocious puberty. Case llis a 2 month old boy who has failure to thrive and frequent episode of dehydration. Case lll is a 5 year and 3 month old girl who has enlarged clitoris without salt craving since birth. All 3 cases have higher level of 17KS than normal but normal blood pressure. Serum 17 OH progesterone or urinary pregnanetriol were not checked. All patients were well responding with corticosteroid and 17 KS in 24 hour urine were decreased to normal. These patients are considered to have 21 hydroxylation defect type in congenital adrenal hyperplasia. Review of literature and references on congenital adrenal hyperplasia was attempted priefly.
Adrenal Hyperplasia, Congenital* ; Blood Pressure ; Clitoris ; Dehydration ; Failure to Thrive ; Female ; Humans ; Hydroxylation ; Hyperplasia ; Infant ; Male ; Parturition ; Pregnanetriol ; Progesterone ; Puberty, Precocious

The nm23 gene was originally identified by differential screening of a cDNA library with RNA from low and high metastatic clones of a murine melanoma cell line. And the nm23 gene has been represented as a metastasis suppressor gene. The product of nm23 gene is known to be identical to nucleoside diphosphate(NDP) kinase. The lack of expression of nm23 protein has been correlated with a poorer prognosis in some human tumors, among which are breast carcinoma, malignant melanoma, gastric carcinoma and hepatcelluar cacin-oma. However, in several types of malignant tumors such as colon carcinoma, neuroblastoma and pancreatic carcinoma, unexpected overexpression of nm23 protein was found as compared with normal tissues. Also in a few studies with cervical carcinoma, the expression of nm23 protein was found to be increased as compared with normal cervical tissue recently. Therefore, in this study, we analyzed the expression of nm23-H1 protein by immunohistochemistry method in a series of 40 cervical carcinomas, to determine whether the alterations in the expression of nm23-H1 protein occured in cervical carcinoma as compared with cervical intraepithelial neoplasia(CIN) and normal cervices, and also analyzed the possible association between nm23 protein expression and prognostic parameters of cervical carcinoma at Ewha Womans University Mokdong Hospital from September 1993 to March 1997. The results obtained were as follows; 1. The mean ages of normal control patients, CIN and cervical carcinomas were 42.9 (+/-5.1) years, 39.5(+/-7.7) years, and 49.3(+/-11.7) years respectively. All cases of cervical carcinoma were squamous cell carcinomas. And the number of each stages Ia, Ib, IIa, IIb, III and IV were 13 cases, 8 cases, 6 cases, 9 cases, 2 cases, and 2 cases respectively. 2. In cervical carcinoma, nm23-H1 protein expression was significantly increased as compared with CIN and normal cervical tissue(t=5.017>1.96). 3. In cervical carcinoma, the nm23-H1 protein expression was more increased in higher stages(p=0.021). But it had no significant correlations with primary tumor size, lymphovascular space invasion, parametrial invasion or lymph node metastasis. Our results on nm23-H1 protein expression in cervical carcinoma suggest that cervical carcinoma seems to belong to the group of tumors, like colon carcinoma and neuroblastoma, pancreatic carcinoma in which nm23-H1 overexpression is associated with a more malignant phenotype. In this study, nm23-H1 protein was more expressed in higher clinical stages of cervical carcinoma. Therefore the expression of nm23-H1 protein probably may have a prognostic significance in cervical carcinoma. But a further prospective study on a larger population is needed to establish the role of nm23 gene in this kind of tumor.
Breast Neoplasms ; Carcinoma, Squamous Cell ; Cell Line ; Cervix Uteri* ; Clone Cells ; Colon ; Female ; Gene Library ; Genes, Tumor Suppressor ; Humans ; Immunohistochemistry ; Lymph Nodes ; Mass Screening ; Melanoma ; Neoplasm Metastasis ; Neuroblastoma ; Phenotype ; Phosphotransferases ; Prognosis ; RNA