Majolin's ulcer is a carcinomatous ulcer from degenerating burn scars. This patient is a 44 year-old man who has been suffering from pain and itching sensation on Rt. wrist of burn scars. Symptom has been developed since 18 months ago. Skin lesion is a well defined, slight brownish colored, scaly verrucous surfared plaque with reddish ringlike border and oozing tendency in small part. On physical examination, he is in within normal limit excepet burn scar on Rt. upper extremity. He was received burn with gasolin at the age of seven. Biopsy on the skin lesion revealed well differentiated squamous cell carcinoma appearance. Diagnosis was confirmed by the history and histopathological finding. Literature was briefly reviewed.
Adult ; Biopsy ; Burns ; Carcinoma, Squamous Cell ; Cicatrix ; Diagnosis ; Humans ; Physical Examination ; Pruritus ; Sensation ; Skin ; Ulcer* ; Upper Extremity ; Wrist

Low back pain patients an controls of shipyard workers were surveyed between June 1995 and september 1995 to identify risk factors of industrial low back pain. The patients were 17 male workers who had got medical treatment for over 3 days because of industrial back pain controls were 51 male workers who had not have musculoskeletal disorder for one year before the survey. By univariate analysis, the workers who did overtime work 4 times or more for the last 2 weeks showed odds ratio of 3.67 on low back pain with the workers who did less overtime work. Carrying heavy materials was also associated with the low back pain and the odds ratio increased with the increase of carrying weight. work space and work posture were not associated with the low back pain significantly. The welder had higher odds ratio than the other workers on low back pain. The duration of employment and job satisfaction did not affect the risk of low back pain. Multiple logistic regression analysis showed that frequency of overtime work for the last 2 weeks and carrying heavy materials among the risk factors were associated significantly with the low back pain. We found that important risk factors of low back pain of shipyard workers are work intensity factors such as overtime work and carrying heavy weight.
Back Pain ; Employment ; Humans ; Job Satisfaction ; Logistic Models ; Low Back Pain* ; Male ; Odds Ratio ; Posture ; Risk Factors*

No abstract available.

Genotoxic agents can induce various DNA lesions. DNA-Protein Crosslinks(DPCs) were known as the important DNA lesions which could impair gene expression because DPCs had a high probability of resisting repair and persisting through cell cycle. This repair resistance of DPCs could have biological significance but had not been evaluated clearly yet. Most of the studies that have evaluated the repair of DPCs only compared the extent of DPCs repair with other DNA lesions. We injected K2CrO4, a genotoxic agent, into Sprague-Dawley rats intraperitoneally(5mg/kg) and isolated blood lymphocytes 12 hours later. These lymphocytes were cultured in the mitogen added growth media and mitogen free media separately. The degree of the repair of DPCs was monitored for 4 days by the K-SDS assay. 4 day later, the amount of DPCs decreased by 4.6% in the mitogen added media but in creased by 10.9% in the mitogen free media. These results showed that DPCs induced by K2CrO4 were not repaired easily and the DPCs were biologically significant DNA lesions. We thought the decrease of DPCs in the mitogen added media was not due to the repair of DPCs, but from the increase of normal cell proliferation. Therefore, it is very important to consider the proliferation of normal cells when estimating the repair of DPCs.
Animals ; Cell Cycle ; Cell Proliferation ; DNA ; Gene Expression ; Lymphocytes* ; Rats* ; Rats, Sprague-Dawley

Most insects including the honeybee cause erythema and edema at the site of a sting in non-allergic individuals. This reaction usually resolves within a few days. However, in certain cases, the persistence of inciting materials in the cutaneous tissue may promote a local inflammatory foreign body reaction. Localized nodular lesions were seen in our two patients and erythemstous patches were present in one patient due to rarely encountered complications induced by retained sting materials. In these cases histopathology showed multiple foci of foreign body granuloma containing yellow refraetile material in the center surrounded by histiocytes and foreign body giant cells. The granulomatous skin lesions in these patients were treated with intralesional injections of triamcinolone acetonide and partial excisions of the nodular masses were performed.
Bites and Stings ; Edema ; Erythema ; Foreign-Body Reaction ; Giant Cells, Foreign-Body ; Granuloma* ; Granuloma, Foreign-Body ; Histiocytes ; Humans ; Injections, Intralesional ; Insects ; Skin ; Triamcinolone Acetonide

No abstract available.
Child* ; Heart Diseases* ; Heart* ; Humans ; Mass Screening*

No abstract available.
Cheek*

This study was carried out to evaluate the cytotoxicity of rock wool fibers(RWFs) such as cell division disturbance, chromosomal and DNA damage, and mutagenicity using cultured cells. RWFs were the man made mineral fibers. In order to find the correlation between the cytotoxicity of RWFs and the phagocytic capacity of cells, the phagocytic processes were observed using scanning electron microscope. Cell division disturbance by RWFs was evaluated by the formation of multinucleated giant cells. The chromosomal damage was evaluated by the micronucleus formation. For the evaluation of oxidative DNA damage, 8-hydroxy-2'-deoxyguanosine (8-OH-dG) formation was measured utilizing calf thymus DNA. Mutagenicity was determined by the point mutation of HGPRT and the effect of RWFs on cell transformation was also observed. 1. Compared with the results of chrysotile, RWFs were no or little effect on the cell growth according to the results done by the tests of cell proliferation inhibition and relative plating efficiency. 2. The frequency of multinucleated giant cell formation was increased by the treatment of RWFs and it was dose-dependent. However, the effect of RWFs was weaker than that of chrysotile. 3. The number of micronuclei formed in the RWFs treated cells was between those of cells treated with chrysotile and those of untreated cells. 4. The 2 fold increase in the formation of 8-OH-dG in calf thymus DNA was observed in the cells treated with RWFs in the presence of H2O2. On the other hand, chrysotile had no effect on the 8-OH-dG formation. 5. RWFs had no effect on the HGPRT point mutation and cell transformation. These results showed that RWFs could induce chromosomal damage, cell division disturbance and oxidative DNA damage in the RWFs treated cells.
Asbestos, Serpentine ; Cell Division ; Cell Proliferation ; Cells, Cultured ; DNA ; DNA Damage ; Giant Cells ; Hand ; Hypoxanthine Phosphoribosyltransferase ; Mineral Fibers ; Point Mutation ; Thymus Gland ; Wool*

The number of migrant workers staying in Korea is 73,250 August 1994 now by the data which Economic Planning Agency presented to the National Assembly. Industrial trainees were reported to be 17,640 and illegal stayers were 55,610 but many migrant workers did not seem to be included. There are some reports which described the unfulfillment of their basic right such as discrimination of wage, delay of payment, long working hours, enforced work, but working conditions, work environment and their health were not surveyed well. Therefore this survey is to study their situation such as working conditions, work environment, health and living conditions as well as general characteristics. Questionnaire was written by plain English and was made of closed question mainly. Finally 185 persons completed the questionnaire. The results are as follows; 1) The general characteristics are following: ages are mostly between 20 and 29 years old, and males are more than females, and mostly unmarried. Many were students in their countries and their education levels were high. 2) Many persons; were introduced to Korea by native broker. Total cost for coming to Korea was mostly over $1,000 and many paid over $2,000. Their staying period in Korea is mostly over 2 years arid many persons think their status uneasy. The most important purpose for coming to Korea is to earn money. 3) Many are working in garment factories but most factories are small scale: ones below 20 employees. Most are working over 10 hours a day. The average income is $480 and that is about 54.8% of average income of Korean workers. Unpaid salaries are about $921 per each worker. 4) 15.8% of migrant workers answered to have experienced industrial accidents. Their health status seems to be worse after coming to Korea. The resident environment was very poor. We knew that migrant workers' situation was very bad considering their working conditions, work environment, health and living conditions. Therefore, employment policy of migrant workers must be reviewed immediately and good working conditions must be provided to them as soon as possible.
Accidents, Occupational ; Adult ; Discrimination (Psychology) ; Education ; Employment ; Female ; Humans ; Korea ; Male ; Questionnaires ; Salaries and Fringe Benefits ; Single Person ; Social Conditions ; Transients and Migrants*

Pigmented lesions of palmar and plantar skin may cause diagnostic problems, because some features of benign lesions in these sites may raise the suspicion of melanoma if considered alone. Transepidermal elimlnation is a mechanism by which a substance is eliminated through the epidermis, and it is apt to be confused with a feature of melanoma that tumor cells are located at all layers of the epidermis. We report a case of transepidermal elimination of nevus cells in acral letiginous nevus which needs a differential dignosis of melanoma.
Epidermis ; Melanoma ; Nevus* ; Skin