No abstract available.
Gangwon-do* ; Orientia tsutsugamushi* ; Rickettsia*

No abstract available.
Ossification, Heterotopic*

BACKGROUND: Oxygen free radicals have been implicated as a cause of deleterious effects in the setting of coronary reperfusion, and they are believed to be generated by the xanthine oxidase system, from activated neutrophiles and from mitochondria. We evaluate the contribution of mitochondria to the production of oxygen free radicals and clarify the mechanism of cellular damage in ischemic reperfused hearts. METHODS: Mitochondria isolated from the ischemic rabbit hearts were incubated in the reaction conditions with different oxygen tensions. Generation of superoxide anion and activities of defensive enzymes aginst oxidative stress were mesured. RESULTS: Superoxide anion genertion by mitochondria incubated in 21% oxygen condition were 0.54+/-0.09 and 0.27+/-0.04(O2./min/mg protein) in ischemic mitochondria and in control respectively(P<0.05). Activites of defensive enzymes against oxidative stress, superoxide dismutase and glutathione peroxidase, were significantly reduced in mitochondria isolated from either ischemic or reperfused hearts. With the lapse of respiration in 21% oxygen condition, ADP-stimulated state 3 oxygen consumption(306.4+/-31.5 vs 214.4+/-11.4n atoms O/min/mg protein) at 30 minutes, P : O ratio and phosphorylation rate were significantly decreased in ischemic mitochondria. CONCLUSION: Elevation of oxygen free radical generation as well as the reduction of defensive enzyme activities in ischemic reperfused mitochondria are injurious to mitochondrial respiratory function. It may contribute to the mechanism of cellular damage in ischemic reperfused hearts.
Free Radicals ; Glutathione Peroxidase ; Heart* ; Mitochondria* ; Myocardial Reperfusion ; Neutrophils ; Oxidative Stress ; Oxygen ; Phosphorylation ; Respiration ; Superoxide Dismutase ; Superoxides* ; Xanthine Oxidase

No abstract available.
Arrhythmias, Cardiac*

No abstract available.
Child* ; Humans ; Tuberculosis, Renal*

Cryptosporidium, a coccidian parasite first described by Tyzzer (1907) from a laboratory mouse, has become an important human enteric pathogen causing overwhelming diarrhea especially in immunocompromised patients such as AIDS. This parasite has been reported from over 20 countries and is recognized as a cosmopolitan species. In Korea, however, there has been no report on human as well as animal cryptosporidiosis. This study was performed so as to verify the presence of Cryptosporidium in Korea by activating the parasite from laboratory mice by immunosuppression. Total 65 conventionally-bred ICR mice including a control (5 mice) and 3 experimental groups (20 each) were used for this study. Group I was immunosuppressed with prednisolone injection (1 mg IM, every other day) for 7 weeks. Group II (prednisolone injection and tetracycline administration) and Group III (prednisolone injection and trimethoprim-sulfamethoxazole administration) were prepared to observe the effect of antibacterial agents on the activation of cryptosporidiosis. In fecal examinations of mice Cryptosporidium oocysts (4-6 microns in size) were detected from 1 week after the start of immunosuppression and the mice began to die. In H-E stained tissue sections of the lower jejunum, numerous very small (2-4 microns), dense, ovoid or spherical, slightly basophilic bodies were seen attached on the free border of mucosal epithelial cells. In scanning and transmission electron microscopic observations, these organisms were identified as various developmental stages of Cryptosporidium. The species is considered to be C. parvum.(ABSTRACT TRUNCATED AT 250 WORDS)
Cryptosporidiosis-etiology ; Cryptosporidiosis-immunology ; Cryptosporidium-growth-and-development ; English-Abstract ; Immune-Tolerance ; Intestinal-Diseases,-Parasitic-etiology ; Intestinal-Diseases,-Parasitic-immunology ; Mice- ; Mice,-Inbred-ICR ; *Cryptosporidiosis-parasitology ; *Cryptosporidium-pathogenicity ; *Immunosuppression- ; *Intestinal-Diseases,-Parasitic-parasitology

No abstract available.
Antibodies* ; Coxiella burnetii* ; Coxiella* ; Korea* ; Prevalence*

It is well-known that the course of phototherapy, stool colour changes from yellow to green. The occurrence of frequent loose green stools, commencing a few hours after the beginning of treatment, has been observed in several different centers. In order to elucidate the machanism by which phototherapy induces loose stools in newborns, studies were perforned on the speed of intestinal transit by performing the carmine red ftest on 15fullterm newborns, 15jaundiced newborns before and after phototherapy and 15 healthy newborns exposed to phototherapy. The following results were obtained. 1) Intestinal transit time in 15 full term newborns was 12.75+_3.54 hours.(Fig. 1). 2) Intestinal transit time before phototherapy was 13.63+_3.21 hours in 15 jaundiced newborns and it was 7.32+_2.76 hours after phototherapy (Fig. 1). 3) Intestinal transit time in 15 healthy newborns was 13.74+_5.14 hours(Fig. 1). A statistically accelerated intestinal transit was observed in jaundiced newborns treated with phototherapy. The increased rate of intestinal transit produced by phototherapy is probably due to the action of the phototherapy.
Carmine ; Humans ; Infant, Newborn* ; Phototherapy*

Ventricular arrhythmia and left ventricular dysfunction after hospital discharge in acute myocardial infarction are powerful predictors of sudden death. We evaluated the ventricular extrasystoles with 24 hour ambulatory electrocardiography at convalescent phase in 34 patients of acute myocardial infarction. Ventricular extrasystoles were observed in 19 patients (56%) and classified by Lown's grading system as grade 1 for 8 cases, grade 2 for 3 cases, grade 3 for 3 cases, grade 4 for 3 cases, and grade 5 for 2 cases. There was no relation between the develoment of ventricular extrasytoles and the risk factors of ischemic heart discase such as smoking, hypertension, hyperlipidemia, diabetes mellitus, and male sex. Also, the development of ventricular extrasystoles was independent to infarct site, regional wall motion abnormalities, and clinical manifestations of left ventricular dysfunction such as congestive heart failure and cardiomegaly. In conclusion, ventricular arrhythmia might independently predict the prognosis in survivors of acute myocardial infarction.
Arrhythmias, Cardiac ; Cardiomegaly ; Chymopapain ; Death, Sudden ; Diabetes Mellitus ; Electrocardiography, Ambulatory ; Heart ; Heart Failure ; Humans ; Hyperlipidemias ; Hypertension ; Male ; Myocardial Infarction* ; Prognosis ; Risk Factors ; Smoke ; Smoking ; Survivors ; Ventricular Dysfunction, Left ; Ventricular Premature Complexes*

No abstract available.
Prostate* ; Testis*