Objective To investigate the clinical features of central nervous system involvement in pSS.Methods The clinical data of 21 CNS-SS patients in our hospital were retrospectively reviewed.Results There were a variety of neuropsychiatrie presentations in pSS,in which 12 patients had brain involvement and 9 patients had spinal cord involvement,accounting for 57.1% and 42.9% respectively.Seven patients had con- current peripheral nervous system involvement.Neurological involvement of 10 patients preceded other syrup- toms of pSS.The mean duration of pSS at the onset of CNS-SS was(4?6)years.Abnormal MRI results had been found in 13 patients,of which 8 patients had demyelination lesions,which was the most frequent presen- tation,and accounted for 38.1%.Cerebral spinal fluid abnormality was seen in 11 CNS-SS patients,among which protein elevation was found in 10,pressure elevation in 6 and white cell count elevation in 5.Conclu- sions Central nervous system may be involved in pSS.MRI and cerebral spinal fluid tests are essential for the diagnosis of CNS-SS.CNS-SS may features of spinal cord and the peripheral nervous system involvement CNS-SS usually carries a mild clinical process and frequently oceurrs in stable pSS.

Integrative medicine is the effective combination of dual diagnosis of Chinese medicine and western medicine.The combination can broaden the scope of clinical diagnosis and combine the local pathological changes with the overall response of the human disease.It can add a more comprehensive understanding of diseases for people.Clinically treated with combination of Chinese medicine and western medicine can achieve the complement of advantages.It is significant.Because the theory system of Chinese medicine compared with western medicine is different and the theory system of combination is not practical and standardized.The methods of clinical diagnosis and treatment are also different.So there are still some problems and deficiencies in the integrative medicine.In this study,through extensive literature research,as well as the clinical investigation in some integrative medicine hospitals and the collection of related clinical data,we compared and analyzed the academic ideas and different features of Chinese medicine and western medicine,analysed the status and the insufficience of current clinical integrative medicine.Finally,we put forward a series of effective strategies and methods for how to combine with integrative medicine in a specific,reasonable and effective way.

AIM: To study whether there was a correlation between central foveal thickness (CFT) assessed with optical coherence tomography (OCT) and visual acuity of patient with high myopia after phacoemulsification and intraocular lens implantation.METHODS: Totally 67 patients with high myopia underwent phacoemulsification and intraocular lens implantation were enrolled in the study.Best corrected visual acuity (BCVA) was recorded and CFT was measured using OCT at 1wk,1 and 3mo after oerations.BCVA and CFT were compared before and after the operation.All patents were divided into two groups by the BCVA at 3mo after operation,BCVA>0.5 in Group A and BCVA≤0.5 in Group B.ANOVA,Spearman correlation analysis and independent t test were used for statistical analysis.RESULTS: There was a statistically significant difference between preoperative BCVA and postoperative BCVA (F=115.04,P<0.01).Preoperative CFT was different compared with that 1wk and 1mo after operation (P=0.04,0.02) and was not different with that 3mo after operation(P=0.52).There was a statistically significant difference in CFT of postoperative 3-month compared with that of postoperative 1-week(P<0.01) or that of postoperative 1-month (P<0.01).BCVA showed significant positive correlation with CFT without foveal lesion on postoperative 3mo (r=0.28,P=0.03).CFT of Group A and Group B was significantly different at 3mo after the operation (t=-2.24,P=0.03).There was no significant difference in age and intraocular lens of two groups.CONCLUSION: Optical coherence tomography allow for objective assessment of retinal construction changes in eyes with high myopia are correlated to visual acuity.

BACKGROUND: Gastric lavage (GL) is one of the most critical early therapies for acute paraquat (PQ) poisoning; however, details of the treatment protocol remain to be established. METHODS: A rapid quantitative method involving sodium dithionite testing was developed. It was validated for the determination of the PQ concentrations in gastric juice and eluate samples from a swine acute PQ poisoning model with early or delay GL, or without. The vital signs, laboratory testing, and PQ plasma concentrations were collected for therapeutic effect evaluation. RESULTS: The reaction conditions of the test were optimized for two types of samples. Early GL at one hour (H1) could improve the signs and symptoms after acute PQ poisoning at 24 hours (H24). In contrast, GL at 6 hours (H6) could only partially relieve the vital signs. The H1 GL group effectively reduced the peak of the plasma PQ concentration. In addition, the PQ concentrations in the plasma and the gastric juice were signifi cantly decreased in both the GL groups as compared to the untreated group at H24. Moreover, there was no signifi cant difference in the washing effi ciencies calculated from the total eluates between the two GL groups. However, the washing effi ciency of the fi rst 10 L eluate is superior to that of the additional 10 L eluate. CONCLUSION: GL only at early stage may it benefit PQ poisoning in an animal model. The currently used 20 L GL volume may need to be reduced in view of the low washing efficiency in the later 10 L eluate. The rapid quantitative method can be used for gastric juice sample and has a certain value for clinical GL practices.

Continuous renal replacement therapy( CRRT) employs convection and adsorption to re-move pro-and anti-inflammatory mediators from plasma, helping to restore the immunologic homeostasis. CRRT also provide uninterrupted clearance of retained endogenous and exogenous toxins, along with acid-base,electrolyte,hemodynamics and volume homeostasis.CRRT may improve outcomes in critically ill pa-tients with sepsis-induced acute kidney injury,septic shock and multiple organ dysfunction syndrome.Region-al citrate anticoagulation, as compared to unfractionated heparin, report better filter survival times and less bleeding.Antibiotic dosing decisions should be individualized to take into account patient-related,CRRT-relat-ed,and drug-related factors.

Cerebral small vessel disease (SVD) is an important subtype of cerebrovascular disease. It is also one of the major reasons for resulting in vascular cognitive impairment or dementia in the elderly. SVD is a small arteriovenous lesion in subcortex caused by a variety of causes, mainly causing subcortical lacunar infarction, white matter damage, microblecds and other pathological changes. There is evidence that vascular endothelial function and blood-brain barrier damage may result in small vessel structures and perivascular changes, which may be the initial factors.of causing SVD. Genetic susceptibility is also one of the risk factors that can not be ignored.

Humans ; Oral Medicine ; Proteomics

Animals ; Humans ; Hyperbaric Oxygenation ; Mandibular Diseases ; prevention & control ; therapy ; Osteoradionecrosis ; prevention & control ; therapy ; Radiation Injuries ; prevention & control ; therapy

Aim To investigate the mechanism of resveratrol decreasing GDF8 expression via activating autophagy in skeletal muscle of obese mice. Methods Male C57BL/6 mice were randomly divided into standard control diet (SCD), SCD treated with resveratrol (SCD + RES), high-fat diet (HFD) and high-fat diet group treated with resveratrol (HFD + RES). The SCD + RES and HFD + RES groups were intervened with resveratrol via gavage daily (400 mg • kg"1 • d-1) for 20 weeks. The body mass, serum TG, TC, LDL-C and HDL-C levels were detected. The pathological changes in skeletal muscle were detected by HE staining. The mRNA, protein distribution and expression of SIRT1, LC3, p62 and GDF8 were assessed by im-munohistochemistry, RT-PCR and Western blot respectively. Results The body mass , serum TG , TC and LDL-C levels increased, while HDL-C levels decreased in HFD group. Lipid deposition between skeletal muscle fibers was obvious in HFD group. The mRNA and protein expressions of GDF8 and p62 increased, while the mRNA and protein expressions of S1RT1 and LC3 decreased. All the response was attenuated by treatment with resveratrol. Conclusions High-fat diet in-\ duces lipid depostion and decreases autophagy in skeletal muscle. Resveratrol treatment significantly attenuates GDF8 expression in skeletal muscle tissues, which may be related with activated SIRTland induced autophagy, thus resulted in the degradation of myostatin.