OBJECTIVE:To analyze the main factors related to the adverse drug reactions (ADRs) and the drug-induced diseases induced by Chinese patent medicines commonly used for cardiovascular diseases. METHODS:With ADRs of Chinese medicine as key word,the original papers about Chinese patent medicine-induced ADRs were retrieved from all the literature from 1998 to 2008 in full-text data base of CHKD periodicals for statistical analysis. RESULTS:The common Chinese patent medicines commonly used for cardiovascular diseases might induce ADRs and drug-induced disease. CONCLUSION:Chinese patent medicine-induced ADRs have various categories and manifeste differently clinically,which call for attention from both medical staff and patients.

OBJECTIVE: To study the similarity and difference of approximate recipes for edema. METHODS: The approximate clinical commonly used recipes for edema were analyzed in respect of medicine constitute, interpretation of the cause, main functions and clinical application of modern Chinese medicine, etc. RESULTS:The similarity and difference of approximate recipes were found out and their key points in clinical application were confirmed. CONCLUSIONS: It must be careful and considerate to identify the type of edema, afford the reasonable recipes and combine the essence of interpretation of the cause when the new therapy methods are put forward according to modern Chinese medicine. Recipes which are chosen and applied according to their similarity and difference can obtain comparatively sound curative effect.

OBJECTIVE:To evaluate the common characteristics and differences of the close herbal prescriptions for coronary heart disease(CHD).METHODS:The close herbal prescriptions for CHD were compared in respect of the compositi-on,pathogenesis,function and indication as well as the clinical application in modern Chinese medicine etc.RESULTS:Great importance should be attached to the differences lie in the 8 groups of close herbal prescriptions for CHD in their clinical application.CONCLUSION:The modern Chinese medicine put forward some new approaches for the treatment of CHD aimed at its patterns of syndrome.In the application of these therapies,syndrome differentiation should be carried out with prudence to choose the most effective therapy in view of the difference of the close prescriptions to achieve a better efficacy.

OBJECTIVE:To provide reference for high blood pressure of different formulas used.METHODS:The similar conventional prescriptions for high blood pressure were compared in respects of constitute of prescription,the machine of disease,main function of prescription,clinical application,etc.RESULTS:The similarity and difference of those prescriptions and the key points of clinical application were found out by analyzing the main function,constitute of prescription and mechanism of disease,etc.CONCLUSION:In the field of modern Chinese medicine,new treatment methods are put forward to some types of high blood pressure disease.It is must careful to indentify type of disease.Sound efficacy can be achieved when suitable prescription is applied according to the similarity and difference of prescriptions.

OBJECTIVE: To analyze the main factors for ADR that is induced by Chinese medicine injection to promote clinical use of drug.METHODS: Literatures about ADR which was induced by Chinese medicine injection for cardiovascular disease were retrieved from CHKD from Jan.1998 to Jun.2009 and analyzed statistically with ADR as .RESULTS: 10 kinds of ADR which were caused by cardiovascular injection were listed.CONCLUSION: Medical personnel and patients should pay attention to numerous kind of ADR resulted from Chinese medicine injection and clinical manifestation.

Objective:To analyze the pulpal prognosis of replanted permanent teeth in children and to examine the associated factors .Methods:The samples consisted of 67 children with 81 avulsed perma-nent teeth treated in Peking University Hospital of Stomatology from 2000 to 2012 .Their clinical data of the replanted teeth were collected , and the follow-up period was no less than 12 months.The pulpal prognosis was classified as pulp necrosis and pulp non-necrosis .Results: The replantation within 30 minutes after avulsion led to the most significant increase in pulpal healing (P<0.05).The dental pulp of 80% ( 4/5 ) young permanent teeth replanted within 30 minutes remained vital , while all the teeth replanted after 30 minutes developed pulp necrosis within 60 days after replantation .Conclusion: The extra-alveolar period significantly affects the prognosis of pulp in immature permanent teeth after replanta-tion.When the extra-alveolar period is more than 30 minutes, the chance of pulp revascularization after replantation is very low , therefore pulp extirpation should be performed .

Objective:To analyze the prognosis about periodontal ligament healing of replanted perma-nent teeth in children and to examine the associated factors.Methods: The sample consisted of 49 children with 61 avulsed permanent teeth, whose injuries had been managed in the period from 2000 to 2012.The clinical data of replanted teeth were collected, and the follow-up period was no less than 12 months .The factors were analyzed in relation to postoperative outcomes, classified as functional periodon-tal healing ( FH ) , infection-related ( inflammatory ) resorption ( IRR ) and replacement resorption ( RR) .Results:The functional healing rate was 23.0%, while replacement resorption rate was 72.1%. The replacement resorption ( ankylosis ) was usually observed earlier by clinical examination than by radiographic examination.86.0% (40/47) resorptive processes were diagnosed within the first year. Physiological storages, such as milk, saline and saliva were significantly better to periodontal ligament healing than nonphysiological storages, such as tap water and sterilizing solutions ( chloramine and alco-hol) .Functional healing was found significantly more frequent in canines and premolars.Conclusion:The factor significantly affecting periodontal ligament healing is storage medium.Replacement resorption is the most common type of root resorption.The replacement resorption diagnosis must combine the radio-graphic examination with the clinical examination.It is better to follow up more than 1 year after tooth re-plantation.

Objective To explore the role of intraleisonal pingyangmycin in the treatment of maxilla and facial vascular malformation.Methods A total of 160 cases with vein malformation were divided into two groups randomly,and were injected pinyangmycin and sod morrhuate,respectively.Results The size of the swelling reduced by 50% or more in 74 patients(92.5%) and by 75% or more in 64 patients(80%) in pinyangmycin group;the size of the swelling reduced by 50% or more in 50 patients(62.5%) and by 75% or more in 34 patients(42.5%) in sod morrhuate group;there was a significant difference in the two groups.Conclusion Intralesional injection of pinyangmycin is an easy,safe,and effective therapeutic method in venous malformation.

The estimation of chronologic age based on the stages of third-molar development was evaluated by using the eight stages (A-H) method of Demirjian and the third-molar development was compared, in terms of sex and age, with results of previous studies. The samples consisted of 291 orthopantomograms from young Chinese subjects of known chronologic age and sex (including 139 males with a mean age of 14.67+/-3.62 y and 152 females with a mean age of 14.85+/-3.70 y). Statistical analysis was performed by employing the Mann-Whitney U-test and the t-test. Regression analysis was conducted to obtain regression formulas for calculating dental age from the chronologic age. Our results showed statistically significant differences (P<0.05) in third-molar development between males and females, at the calcification stages D, E and H. And a strong correlation was found between age and third-molar development in both males (r (2)=0.65) and females (r (2)=0.61). New equations (Age=8.76+1.32 Development stage) for estimating chronologic age were derived. It is concluded that third-molar genesis took place earlier in males than in females. The use of third molars as a developmental marker is appropriate in young adults of Central China. The formula obtained in the present study can be used as a guide for estimation of dental maturity and a standard for age estimation for young adults of Central China.

Objective To investigate the effects of recombinant human fibronectin fragment (RetroNectin) combined with anti-CD3 monoclonal antibody (CD3Ab) on the proliferation and cytotoxicity of cytokine-induced killer cells (CIK) from acute leukemia (AL). Methods Mononuclear cells (MNCs) were isolated from peripheral blood of complete remission AL pa-tients. The MNCs were cultured in vitro by precoating with RetroNectin (RN group), CD3Ab (CD3Ab group), RetroNectin com-bined with CD3Ab (RN+CD3Ab group) and traditional method (control group) to generate CIK. The changes of growth rate, characterization, cytotoxicity and apoptosis of CIK were determined between groups. Results The amplification of CIK was higher in experimental group than that of control group, and the amplification of CIK was higher in group RN+CD3Ab than that of in group RN and group CD3Ab (P＜0.05). The expression of CD25 positive cells was higher in group RN and group RN+CD3Ab than that of group CD3Ab and control group (P＜0.05).The percentage of G1 stage cells was lower in group RN and group RN+CD3Ab than that of group CD3Ab and control group. The percentage of S stage cells was higher in group RN and group RN+CD3Ab than that of group CD3Ab and control group (P＜0.05). The cytotoxicity was higher in group RN and group RN+CD3Ab than that of group CD3Ab and control group (P＜0.05) at the E/T scope 40∶1.The percentage of apoptotic cells was lower in group RN and group RN+CD3Ab than that of group CD3Ab and control group (P ＜ 0.05). Conclusion These in vitro studies suggest that a higher activity of immune cells could be obtained by CIK cells cultured by precoating Ret-roNectin and CD3Ab.