1.A Retrospective Study on the Low Dose Lamotrigine of Skin Disorders
Yosuke MORITA ; Kyohei WATANABE ; Takaaki KODAWARA ; Yumi TSUBOTA ; Ryoichi YANO ; Hitoshi TSUKAMOTO ; Nobuyuki GOTO
Japanese Journal of Drug Informatics 2022;23(4):178-182
Objective: In this study, we investigated the occurrence of skin damage following the initiation of low-dose lamotrigine.Methods: We retrospectively analyzed the incidence of skin disorders within 8 weeks of the start of lamotrigine administration, prescribing for 3 years from July 2014 to June 2016.In addition, we also confirmed the onset time of skin disorders in the low- and normal-dose groups.Results: The incidence of skin damage was 7.7 and 24.6 % in the low- and normal-dose lamotrigine start groups, respectively. The onset of skin disorders was relatively early in the normal-dose lamotrigine start group.On the other hand, no tendency was found in the low-dose lamotrigine start group because the number of cases was small.Conclusion: The initiation of low-dose lamotrigine and extension of introduction period might reduce the onset of early skin damage.
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