Peer review anti assessment includes the evaluation of expert and index system in two parts.The current status of anti-assessment study mainly focused on expert,much of the index system anti-assessment study reports.As can be seen from the status,the anti-assessment system not yet formed and the application is rare.In urgent need of further research to improve our peer-reviewed scientific research.

Objective: To investigate the predictive value of mean platelet volume/platelet count ratio (MPV/PC) for short-term outcome in patients with acute noncardioembolic stroke. Methods: Patients with acute noncardioembotic stroke admitted to the Department of Neurology, the Second Hospital of Tianjin Medical University from April 2018 to April 2019 were retrospectively enrolled. According to the modified Rankin Scale (mRS) score at discharge or 14 days after onset, patients were divided into the good outcome group (mRS 0-2) and the poor outcome group (mRS >2). The demographic, baseline clinical data, laboratory findings were collected and compared between the good outcome group and the poor outcome group. MPV/PC values were calculated according to the average platelet volume and platelet count in blood routine. Multivariate logistic regression analysis was used to determine the independent predictive factors of poor outcome. Receiver operating characteristic (ROC) curves analysis was used to evaluate the predictive value of MPV/PC for poor outcome. Results: A total of 596 patients with acute noncardioembolic stroke were enrolled, including 391 (65.60%) with good outcome and 205 (34.40%) with poor outcome. MPV/PC in the poor outcome group was significantly higher than that in the good outcome group (0.06±0.08 vs. 0.04±0.03; t=-4.392, P<0.001). Multivariate logistic regression analysis showed that MPV/PC was an independent predictive factor for the poor outcome (odds ratio 1.088, 95% confidence interval 1.042~1.137; P<0.001). ROC curve analysis showed that the best cut-off value for MPV/PC to predict poor oucotme was 0.050, the area under the curve was 0.772 (95% confidence interval 0.732~0.812), the sensitivity was 62.1%, the specificity was 81.6%, the positive predictive value was 86.3%, and the negative predictive value was 92.2%. Conclusion MPV/PC is an independent predictive factor for poor short-term outcome in patients with acute noncardioembolic stroke, and has certain predictive value.

Objective:To investigate the clinical characteristics and correlation of sleep disturbances(SD)with cognitive impairment-associated cerebral small vascular disease(CSVD-CI)in elderly patients.Methods:In this cross-sectional study, 261 elderly CSVD-CI patients admitted to the Department of Neurology, Second Hospital of Tianjin Medical University between December 2019 and December 2021 were continuously enrolled.The Pittsburgh Sleep Index Scale(PSQI)was used to evaluate the overall sleep quality.Those with a PSQI score ≥7 was assigned to the CSVD-CI with sleep disturbances(CSVD-CI-SD)group, while those with a PSQI score <7 was assigned to the CSVD-CI without SD(CSVD-CI-NSD)group.The Montreal Cognitive Assessment(MoCA)was used to evaluate the cognitive function of patients with CSVD-CI, and scores on the overall cognitive function and various cognitive domains were compared between the CSVD-CI-SD group and the CSVD-CI-NSD group.Results:There were no significant differences between the CSVD-CI-SD group and the CSVD-CI-NSD group in sex ratio, age, education level and comorbidities( P>0.05). Compared with the CSVD-CI-NSD group, patients in the CSVD-CI-SD group took longer to fall asleep, had worse sleep efficiency, a shorter sleep duration, more obvious SD at night, worse sleep quality, more use of sleeping drugs, and more obvious daytime dysfunction(all P<0.05). Compared with the CSVD-CI-NSD group, the total MoCA score, attention score and orientation score in the CSVD-CI-SD group were significantly decreased( P<0.01). Correlation analysis results showed that the total MoCA score and attention in the CSVD-CI-SD group were negatively correlated with SD at night( r=-0.198, r=-0.115, P<0.05 for both), and orientation was negatively correlated with sleep quality( r=-0.170, P<0.05). Conclusions:The prevalence of SD is high in CSVD-CI patients, with CSVD-CI-SD patients showing more obvious overall cognitive, attention and orientation impairment in MoCA.Additionally, the total MoCA score and attention are negatively correlated with nighttime SD, and orientation is negatively correlated with sleep quality in CSVD-CI-SD patients.

Objective    To compare the clinical outcomes of transcatheter aortic valve implantation (TAVI) in oncology and non-oncology patients with severe aortic stenosis (AS). Methods    A computer-based search in PubMed, The Cochrane Library, EMbase, CBM, CNKI and Wanfang databases from their date of inception to December 2021 was performed, together with reference screening, to identify eligible clinical trials. Two investigators screened the articles, extracted data, and evaluated quality independently. RevMan 5.3 and Stata 12.0 softwares were used for meta-analysis. Results    The selected 8 cohort studies contained 57 988 patients, including 12 335 cancer patients and 45 653 non-cancer patients. The results of meta-analysis showed that in patients with cancer, the 30-day mortality [OR=0.74, 95%CI (0.65, 0.84), I2=0%, P<0.000 01], stroke [OR=0.87, 95%CI (0.76, 0.99), I2=0%, P=0.04] and acute kidney injury [OR=0.81, 95%CI (0.76, 0.85), I2=49%, P<0.000 01] were lower than those in patients without cancer. The 1-year mortality [OR=1.46, 95%CI (1.15, 1.86), I2=62%, P=0.002] and late mortality [OR=1.51, 95%CI (1.24, 1.85), I2=61%, P<0.000 1] were higher in patients with cancer. Conclusion    It is effective and safe in cancer patients with severe AS undergoing TAVI. However, compared with patients without cancer, it is still high in long-term mortality, and further study of the role of TAVI in cancer patients with AS is necessary.