Objective To explore the clinical effects of treating acute radioactive stomatitis with Xiufu Decoction by mouth-washing and oral-taking. Methods All 108 cancer patients were recruited into a treatment group (n=56) and a control group (n=52). The treatment group was treated with Xiufu Decoction for 15 days, and the control group was treated with Nystatin tabletsfor 15 days, 3 times/day. Results There was significant difference between the two groups in odynolysis time, the control of mycotic stomatitis, life condition, and overall effects (P<0.01 or P<0.05). All patients in the treatment group completed the whole course of radiotherapy; while 5 patients in the control group suspended the radiotherapy due to serious mouth ulcer. Conclusion Xiufu Decoction has the functions of enhancing immunity, fixing wound surface, relieving pain, improving diet and sleep, raising life quality, and safeguarding the process of radiation therapy, besides the decoction is safe and without toxic effect.

[Objective] To investigate the clinical efficacy of nasal endoscopic assisted by-mouth low-temperature plasma radiofrequency ablation for treating the children with adenoid hypertrophy.[Methods] Seventy patients with adenoid hypertrophy were divided by random digits table method into treatment group and control group with 35 cases each.The patients in control group underwent traditional by-mouth adenoidectomy,while the patients in treatment group were treated with nasal endoscopic assisted by-mouth low-temperature plasma radiofrequency ablation.The operative time and intraoperative blood loss in two groups were calculated.The children were followed up for 6-12 months and the clinical efficacy of snoring,nasal obstruction and hearing and the postoperative complications were observed.[Results]The intrsoperative blood loss in treatment group was significantly lower than that in control group[(2.23±0.74)ml vs.(24.58±8.19)ml](t=19.733,P ＜ 0.01).The total efficiency of snoring,nasal obstruction and hearing in treatment group was 91.4％(32/35),82.9％(29/35)and 77.1％(27/35),respectively,and which was significantly higher than that in control group[68.6％(24/35),62.9％(22/35)and 57.1％(20/35)](x2 =5.354,5.293,5.421,P＜0.01).There,was no residual adenoid and adenoidal hypertrophy recurrence in treatment group,while the postoperative residual adenoid rate in control group was 91.4％(32/35),the adenoidal hypertrophy recurrence rate was 20.0％(7/35).There was significant difference in postoperative complication incidence between two groups(x2 =9.391,P ＜ 0.01).[Conclusions] Nasal endoscopic assisted by-mouth low-temperature plasma radiofrequency ablation for treating the children with adenoid hypertrophy has better clinical efficacy,less intraoperative blood loss,no postoperative residual and other complications.It is an ideal method for treating the children with adenoid hypertrophy and worthy of clinical application.

Objective To study the effects of mild hypothermia on secondary cerebral vasospasm and levels of endothelin(ET),calcitonin gene-related peptide(CGRP)in CSF and plasma in patients with subarachnoid hemorrhage(SAH).Methods 56 patients with SAH were randomly divided into mild hypothermia group and control group.Based on the routine treating method,patients of mild hypothermia group were treated with local mild hypothermia.The levels of ET,CGRP in CSF and plasma were detected before and after treatment.And the incidence rates of secondary cerebral vasospasm cases were compared between the two groups.Results(1)At 7 d,14 d after treatment,ET levels in CSF and plasma in mild hypothermia group were significant lower than those in control group(P

A method was evaluated for determination of twenty-one doping (including nandrolone, boldenone and methandienone) in human urine by gas chromatography-high resolution mass spectrometry. Samples were prepared by liquid-liquid extraction, concentrated, TMS derivatization and limit of detection at ng x mL(-1) by MID/GC/HRMS. According to the code of the World Anti-Doping Agency (WADA), precision and recoveries of the procedure were evaluated by replicate analysis (n = 6), the recoveries in the range of 66%-103%, with the RSD below 10.0%. The precision within the day of the method with three different concentrations was also determined RSD were less than 9.5%, 10.0% and 9.7%.

Objective To explore the factors influencing the patients' treatment compliance infected with chronic hepatitis B virus, and provide some useful advices to improve patients compliance. Methods Data were collected through deep interviews with 9 patients and analyzed using a phenomenological hermeneutic method. Results Using generic analysis, the factors influencing patients' compliance fell in-to three themes: (1) The enforceability of the doctor's advice; (2)The factors of the patients their own, in-cluding the disease-related knowledge, the realization of how harmful the disease is, and past behavior habits; (3)The social factors, including economic situation, pressure of life, family care, and the supervision and guidance of health care workers. Conclusions In order to make the patients consciously adopt the doctor's advice, health workers should pay more attention to strengthen the enforceability of the doctor's ad-vice and health education, and focus on the impact of cognitive, psychological and social factors on pa-tients' compliance.

BACKGROUND:Researches have found that minocycline plays a neuroprotective effect by inhibiting the microgliacel proliferation and activation and suppressing glial cels to release cytokines and chemokines. OBJECTIVE:To investigate the influence of minocycline on glial cel line derived neurotrophic factor, NTN and gene expression in substantia nigra and corpus striatum in Parkinson’s disease model rats.
METHODS:144 rats were randomly divided into four groups, with 36 rats in each group. In the normal control group, no intervention was given. In the model and experimental groups, 6-hydroxydopamine was injectedin the right substantia nigra pars compacta and ventral tegmental area to establish Parkinson’s disease models. In the sham surgery group, vitamin C was injected in the two points. In the experimental group, after model establishment, rats were intragastricaly given 4.5 g/L minocycline 45 mg/kg. From then on, additional 22.5 mg/kg minocycline was added every 12 hours. The last group was normal control group. Immediately, 12 hours, 1, 7, 14 and 21 days after model induction, SP immunohistochemistry was used to detect the expression of glial cel line derived neurotrophic factor and NTN expression in the substantia nigra and corpus striatum. RT-PCR was used to identify glial cel line derived neurotrophic factor and NTN mRNA expression in the substantia nigra and corpus striatum.
RESULTS AND CONCLUSION:Both in the substantia nigra and corpus striatum, the positive cel number and relative gene expression of glial cel line derived neurotrophic factor and NTN were lower in the model group than in the normalcontrol and sham surgery groups (P< 0.05). Glial cel line derived neurotrophic factor-and NTN-positive cel number and relative expression were higher in the experimental group than in the model group (P< 0.05). These findings suggest that minocyclinecan delay the process of Parkinson’s disease pathogenesis by promoting glial cel line derived neurotrophic factor protein and gene expression.

Objective To observe the expression of acid-sensing ion channel la (ASICla) and to investigate the effect of intracellular Ca2 + concentration on focal cerebral ischemia in diabetic rats.Methods 108 male Wistar rats were divided into three groups:group A [rats with middle cerebral artery occlusion (MCAO)],group B [rats with MCAO and diabetes (DM + MCAO)],group C [rats with MCAO and diabetes treated with fasudil intervention (DM+ MCAO+ fasudil)] (n=36 each).Samples were obtained at the time points of 1,3,6 and 24 h after ischemia respectively (n=9).Models of MCAO and DM+MCAO were prepared.Rats in DM+MCAO+Fasudil group were treated with fasudil 1 mg/Kg by caudal vein injection after half an hour when DM+MCAO model successfully prepared.ASICla expressions were detected at different time points of ischemia in the 3 groups respectively.Ca2+ concentration in ischemia cortex cells were determined at different time points of ischemia in group B and C.Results ASICla expressions were gradually increased along with the ischemia time in group A and B (group A:0.71±0.10,0.80±0.11,0.86±0.08,0.93±0.09;groupB:0.86±0.11,1.05±0.51,2.42±0.08,2.78±0.04; all P＜ 0.05),and ASICla expressions at different time points were higher in group B than in group A (all P＜ 0.05).Ca2-concentration were gradually increased along with the ischemia time in group B (106.32± 18.6,137.84±14.32,151.94± 18.38,183.61±7.96,all P＜0.05).Compared with group B,the levels of ASICla expression and calcium current were reduced in group C.Conclusions The activation of ASICla increases calcium ion flow internal pathway leading to intracellular calcium overload,which may be one of the reasons for the aggravation of focal cerebral ischemia in diabetes.

Objective:To detect the polymorphism of ALDH2 gene in Chinese and to guide the rational use of nitroglycerin. Meth-ods:The polymorphism of ALDH2 (Glu504Lys) was measured by colorful gene chip. Results:The polymorphism of ALDH2 from 1026 clinical samples in China was detected by gene chip. The results showed that there were three genotypes. The distribution of the three genotypes of wild type [ALDH2(504Glu)], heterozygotes [ALDH2(Glu504Lys)] and homozygous mutant [ALDH2(504Lys)] was 61. 7%(623 samples), 31. 6%(319 samples) and 6. 6%(67 samples), respectively. Conclusion:Approximately one third of Chinese patients can not be treated by nitroglycerin. The gene detection method in the study is suitable for the guide of rational drug use in hospi-tal.

Objective To study the clinical effects of treating radiodermatis with acupoint massage and wet compress of Chinese medicine. Methods 104 patients with radiodermatis were randomly recruited into a control group and a treatment group, with 52 patients in each group. The treatment group was treated with acupoint massage plus wet compress of chiense medicines; with the treatment group was externally applied with Kangbao Shaoshang moistening ointment. The result was compared after the treatment. Results The time for easement of pain in the treatment group was obvious reduced than the control group after the treatment. The total effective rate was 96.1% and 57.69% in the treatment group and the control group respectively, the difference showing statistical significance (χ2=27.3, P＜0.01). Conclusion It was effective to treat radiodermatitis with acupoint massage and wet compress of Chinese medicine.

OBJECTIVE:To construct the database of“The Time and Age Limit in the Use of Common Orally Adminis-tered Drugs”in order to guide the rational drug use in patients.METHODS:The frequently used instructions of common orally administered drugs in the hospital where the authors worked were collected,and then were classified and listed according to the elements in“The Time and Age Limit in the Use of Common Orally Administered Drugs”,and further summarized according to the basic knowledge in drug administration.RESULTS:Ante cibum drugs accounted for22.2%,post cibum drugs11.7%,either ante cibum or post cibumor or unmarked drugs59.4%,bedtime drugs6.7%,wholly swallowed drugs12.2%,chewed drugs1.7%,children restricted drugs32.2%,and the drugs taken once daily with the set time accounted for13.9%.CONCL_ USION:The construction of“The Time and Age Limit in the Use of Common Orally Administered Drugs”database can guide patients to use medicine rationally.