Objective:To analyze the changing trend of intracerebral hemorrhage (ICH) incidence among residents with different characteristics during 9 years of comprehensive hypertension prevention and control (hypertension prevention and control) in Tengzhou from 2013 to 2021.Methods:From January 1, 2013 to December 31, 2021, the new ICH cases collected by the Center for Disease Control and Prevention in Tengzhou City were analyzed to calculate the incidence of ICH, and the trend of its distribution was analyzed among residents with different ages, sexes, and between urban and rural areas. The registered population information came from Tengzhou Public Security Bureau. Age and sex standardized incidence was calculated based on the 7th National Population Census in 2020. The Cochran-Armitage test was used to analyze the time and age trends of the incidence.Results:The overall ICH crude and standardized incidence in Tengzhou City decreased from 97.30/100 000 to 52.13/100 000 ( Z=-9.93, P<0.001) and 119.30/100 000 to 50.69/100 000 ( Z=-15.40, P<0.001) from 2013 to 2021, and both elevated to form a single peak in 2020, with 22.58% ( χ 2=24.02, P<0.001) and 18.09% ( χ 2=17.08, P<0.001) higher than in 2019, respectively. The trends in male and female incidence over the same period were similar to the overall trends, and the incidence was higher in males than in females in all years. The incidence of ICH increased with age in all years. The difference of increase in male incidence rate in 2020 was statistically significant in three age groups ≥45 years compared with 2019 (36.29%, 23.57% and 16.18%, respectively, χ 2=6.73, 4.65, 4.00, P<0.001). The incidence of ICH decreased by 70.07% and 36.23% ( Z=18.44, 5.22, P<0.001) in urban and rural areas respectively from 2013 to 2021, whereas increased by 34.15% ( χ 2=10.88, P<0.01) and 22.08% ( χ 2=18.63, P<0.001) in 2020 compared with 2019 separately. Conclusions:The incidence of ICH in Tengzhou from 2013 to 2021 showed a significant downward trend, with the decrease in the incidence of ICH in women exceeding that in men. The decrease in the incidence of ICH in urban areas exceeded that in rural areas, and male morbidity seemingly had a younger trend.

Objective To compare the effect of intravenous combined with oral hydration and routine hydration in the prevention of contrast induced nephropathy in patients with chronic renal insufficiency. Methods A total of 48 patients who were undergoing percutaneous coronary intervention or diagnosis were randomized divided into the short-time hydration group ( 25 cases ) and the conventional hydration group (23 cases). Patients in the short-time hydration group received intravenous hydration at 3 ml/(kg·h) from 1 hour before the operation to 4 hours after the operation, and oral hydration at 1 ml/( kg·h) rate from 4 hours before the operation to 10 hours after the operation. Patients in the conventional hydration group received intravenous hydration at 1 ml/( kg·h) from 12 hours before the operation to 12 hours after the operation. Levels of Serum creatinine ( Scr) and Cystatin C ( CysC) were measured 1 d, 2 d and 3 d preoperative and postoperative, and the incidence of contrast induced nephropathy between two groups was statistically analyzed.Results There was no significant difference in blood Scr, CysC of 1 d, 2 d and 3 d preoperative and postoperative and incidence of contrast nephropathy between two groups ( P>0. 05 ) . Conclusions The effect of short time intravenous combined with oral hydration and routine hydration in the prevention of contrast induced nephropathy has no difference in patients with chronic renal insufficiency.