Objective To explore the differences in neural activity between patients with anorexia nervosa(AN)and healthy controls(HC),as well as the association between these differences and symptoms in AN patients,using activation likelihood estimation(ALE)meta-analysis.Methods The literature search covered the period from 2000 to March 2025.From a pool of 588 identified studies,4 studies focusing on the neural activity differences between AN patients and HC were selected for inclusion.These studies comprised 106 participants and 21 sets of coordinates.The ALE meta-analysis method was employed,and the GingerALE software was used to systematically analyze the reported brain region changes and their peak coordinates,aiming to investigate the differences in brain functional activity between AN patients and HC.Results Compared to the HC group,AN group showed significantly enhanced activation in the left parahippocampal gyrus/amygdala(ALE value=0.39×10-2),right parahippocampal gyrus/amygdala(ALE value=0.39×10-2)and suboccipital gyrus(ALE value=0.39×10-2),along with a significant reduction in activation in Brodmann area 17(ALE value=0.61×10-2)(P<0.01,FWE corrected).Conclusion Key brain regions in AN patients including the parahippocampal gyrus,inferior occipital gyrus,and amygdala demonstrate significant functional activation abnormalities.

Objective To investigate the efficacy of extracorporeal shock wave therapy(ESWT)combined with ultrasound-guided corticosteroid injection(CSI)for the treatment of primary frozen shoulder(PFS).Methods Ninety-nine patients with PFS who visited the pain department of the Affiliated Hospital of Xuzhou Medical University between April 2024 and July 2024 were enrolled and randomly divided into three groups according to the randomized number table method:ESWT group(T group),CSI group(I group),and combined treatment group(TI group),with 33 patients in each group.Visual analogue scale(VAS)scores,shoulder range of motion(SROM),and Constant-Murley shoulder scores(CMS)were recorded before treatment and at 1,4,8,and 12 weeks post-treatment.Additionally,the patients'Ascens Insomnia Scale(AIS)scores were recorded before treatment and 1 month after treatment.The occurrence of adverse effects and the use of remedial medications during the treatment period were also documented.Results Compared with pre-treatment,VAS scores decreased,and SROM and CM scores improved at all time points after treatment in all three groups(P<0.05).AIS scores also decreased in all three groups at 1 month post-treatment(all P<0.05).Intergroup comparisons revealed that the TI group exhibited signifi-cantly lower VAS pain scores,greater SROM(forward flexion and backward extension),and higher CM scores at 4,8,and 12 weeks post-treatment compared to the T and I groups(Bonferroni-corrected P<0.05).No statistically significant differences were observed between the T and I groups for these measures(Bonferroni-corrected P>0.05).Additionally,there were no statistically significant differences in AIS scores or adverse effects occurrence among the three groups at 1 month post-treatment(P>0.05).Conclusion The combined treatment demonstrated greater efficacy compared to trigger point extracorporeal shock wave therapy alone and periapical steroid injection alone,resulting in significant improvement in the patient's clinical symptoms and quality of life.

Objective To explore the differences in neural activity between patients with anorexia nervosa(AN)and healthy controls(HC),as well as the association between these differences and symptoms in AN patients,using activation likelihood estimation(ALE)meta-analysis.Methods The literature search covered the period from 2000 to March 2025.From a pool of 588 identified studies,4 studies focusing on the neural activity differences between AN patients and HC were selected for inclusion.These studies comprised 106 participants and 21 sets of coordinates.The ALE meta-analysis method was employed,and the GingerALE software was used to systematically analyze the reported brain region changes and their peak coordinates,aiming to investigate the differences in brain functional activity between AN patients and HC.Results Compared to the HC group,AN group showed significantly enhanced activation in the left parahippocampal gyrus/amygdala(ALE value=0.39×10-2),right parahippocampal gyrus/amygdala(ALE value=0.39×10-2)and suboccipital gyrus(ALE value=0.39×10-2),along with a significant reduction in activation in Brodmann area 17(ALE value=0.61×10-2)(P<0.01,FWE corrected).Conclusion Key brain regions in AN patients including the parahippocampal gyrus,inferior occipital gyrus,and amygdala demonstrate significant functional activation abnormalities.

Objective To investigate the efficacy of extracorporeal shock wave therapy(ESWT)combined with ultrasound-guided corticosteroid injection(CSI)for the treatment of primary frozen shoulder(PFS).Methods Ninety-nine patients with PFS who visited the pain department of the Affiliated Hospital of Xuzhou Medical University between April 2024 and July 2024 were enrolled and randomly divided into three groups according to the randomized number table method:ESWT group(T group),CSI group(I group),and combined treatment group(TI group),with 33 patients in each group.Visual analogue scale(VAS)scores,shoulder range of motion(SROM),and Constant-Murley shoulder scores(CMS)were recorded before treatment and at 1,4,8,and 12 weeks post-treatment.Additionally,the patients'Ascens Insomnia Scale(AIS)scores were recorded before treatment and 1 month after treatment.The occurrence of adverse effects and the use of remedial medications during the treatment period were also documented.Results Compared with pre-treatment,VAS scores decreased,and SROM and CM scores improved at all time points after treatment in all three groups(P<0.05).AIS scores also decreased in all three groups at 1 month post-treatment(all P<0.05).Intergroup comparisons revealed that the TI group exhibited signifi-cantly lower VAS pain scores,greater SROM(forward flexion and backward extension),and higher CM scores at 4,8,and 12 weeks post-treatment compared to the T and I groups(Bonferroni-corrected P<0.05).No statistically significant differences were observed between the T and I groups for these measures(Bonferroni-corrected P>0.05).Additionally,there were no statistically significant differences in AIS scores or adverse effects occurrence among the three groups at 1 month post-treatment(P>0.05).Conclusion The combined treatment demonstrated greater efficacy compared to trigger point extracorporeal shock wave therapy alone and periapical steroid injection alone,resulting in significant improvement in the patient's clinical symptoms and quality of life.

Objective: Metastases in the supragastric lesser sac (SGLS) are not only occult but are also barriers to complete resection of ovarian cancer. We describe a cohort of patients with SGLS disease undergoing debulking surgery. Methods: We identified all patients who underwent evaluation and eventual resection of SGLS disease as part of cytoreductive surgery for stage IIIC–IVB high-grade epithelial ovarian cancer at our institution from January 2018 to August 2022. Results: Thirty-three of 286 patients (11.5%) underwent resection of SGLS disease.Metastases in the SGLS were identified by preoperative imaging in 4 of 33 patients (12.1%). The median peritoneal cancer index score was 22 (range, 9–33). Through surgical exploration, metastases were frequently seen in the right diaphragm (100%), hepatorenal recess (97%), lesser omentum (81.8%), left diaphragm (78.8%), supracolic omentum (75.8%), anterior transverse mesocolon (72.7%), splenic hilum (63.6%), ligamentum teres hepatis (60.6%), and gallbladder fossa (51.5%). The lesser omentum was normal in 6 of 33 (18.2%) patients, despite metastases within the SGLS. A total of 54.5% of patients underwent complex surgery (surgical complexity scores; median, 8; range, 3–14). Complete resections were achieved in 19 (57.6%) patients. No complications were related to the resection of SGLS disease. The median length of progression-free survival was 24.8 months (95% confidence interval=16.6–32.9). Conclusion Metastases to the SGLS are not uncommon in advanced ovarian cancer, particularly those with widely disseminated disease. Disease in this recess is rarely identified by preoperative imaging and deserves systematic surgical exploration to attain complete cytoreduction.

Objective:To investigate the effectiveness of preeclampsia risk prediction models based on maternal risk factors during the first trimester in a local population.Methods:This was a diagnostic study. Pregnant women who underwent prenatal examination in People′s Hospital of Rizhao from May 2019 to May 2022 and had risk factors for preeclampsia were enrolled at 11-13 +6 weeks gestation, and were divided into preterm preeclampsia group, term preeclampsia group and non-preeclampsia group according to the occurrence and the gestational week. Baseline clinical data were collected. The effectiveness of different models in predicting preeclampsia risk was evaluated using receiver operating characteristic (ROC) curves. Results:Among the 559 pregnant women enrolled, 78(14.0%) had preeclampsia, including 35(6.3%) with preterm preeclampsia (preterm preeclampsia group), 43 (7.7%) with term preeclampsia (term preeclampsia group), and 481 (86.0%) without preeclampsia (non-preeclampsia group).The most effective model for predicting preterm preeclampsia in the first trimester was maternal risk factor+mean arterial pressure (MAP)+serum placental growth factor (PLGF)+uterine artery pulse index (UTPI). The area under ROC curve was 0.805, and the sensitivity was 56.6% with a false-positive rate of 10%; the most effective model for predicting term preeclampsia and preeclampsia was maternal risk factor+MAP+UTPI. The area under ROC curve was 0.777, and the sensitivity was 52.6% and 53.5% with a false-positive rate of 10%.Conclusion:The combined predicting strategy for preterm preeclampsia based on maternal risk factors in the first trimester maybe effective among our population.

Objective: Metastases in the supragastric lesser sac (SGLS) are not only occult but are also barriers to complete resection of ovarian cancer. We describe a cohort of patients with SGLS disease undergoing debulking surgery. Methods: We identified all patients who underwent evaluation and eventual resection of SGLS disease as part of cytoreductive surgery for stage IIIC–IVB high-grade epithelial ovarian cancer at our institution from January 2018 to August 2022. Results: Thirty-three of 286 patients (11.5%) underwent resection of SGLS disease.Metastases in the SGLS were identified by preoperative imaging in 4 of 33 patients (12.1%). The median peritoneal cancer index score was 22 (range, 9–33). Through surgical exploration, metastases were frequently seen in the right diaphragm (100%), hepatorenal recess (97%), lesser omentum (81.8%), left diaphragm (78.8%), supracolic omentum (75.8%), anterior transverse mesocolon (72.7%), splenic hilum (63.6%), ligamentum teres hepatis (60.6%), and gallbladder fossa (51.5%). The lesser omentum was normal in 6 of 33 (18.2%) patients, despite metastases within the SGLS. A total of 54.5% of patients underwent complex surgery (surgical complexity scores; median, 8; range, 3–14). Complete resections were achieved in 19 (57.6%) patients. No complications were related to the resection of SGLS disease. The median length of progression-free survival was 24.8 months (95% confidence interval=16.6–32.9). Conclusion Metastases to the SGLS are not uncommon in advanced ovarian cancer, particularly those with widely disseminated disease. Disease in this recess is rarely identified by preoperative imaging and deserves systematic surgical exploration to attain complete cytoreduction.

Objective: Metastases in the supragastric lesser sac (SGLS) are not only occult but are also barriers to complete resection of ovarian cancer. We describe a cohort of patients with SGLS disease undergoing debulking surgery. Methods: We identified all patients who underwent evaluation and eventual resection of SGLS disease as part of cytoreductive surgery for stage IIIC–IVB high-grade epithelial ovarian cancer at our institution from January 2018 to August 2022. Results: Thirty-three of 286 patients (11.5%) underwent resection of SGLS disease.Metastases in the SGLS were identified by preoperative imaging in 4 of 33 patients (12.1%). The median peritoneal cancer index score was 22 (range, 9–33). Through surgical exploration, metastases were frequently seen in the right diaphragm (100%), hepatorenal recess (97%), lesser omentum (81.8%), left diaphragm (78.8%), supracolic omentum (75.8%), anterior transverse mesocolon (72.7%), splenic hilum (63.6%), ligamentum teres hepatis (60.6%), and gallbladder fossa (51.5%). The lesser omentum was normal in 6 of 33 (18.2%) patients, despite metastases within the SGLS. A total of 54.5% of patients underwent complex surgery (surgical complexity scores; median, 8; range, 3–14). Complete resections were achieved in 19 (57.6%) patients. No complications were related to the resection of SGLS disease. The median length of progression-free survival was 24.8 months (95% confidence interval=16.6–32.9). Conclusion Metastases to the SGLS are not uncommon in advanced ovarian cancer, particularly those with widely disseminated disease. Disease in this recess is rarely identified by preoperative imaging and deserves systematic surgical exploration to attain complete cytoreduction.

Objective To investigate the predictive value of stress glucose elevation and partial pressure of end-expiratory carbon dioxide (PETCO2) on the prognosis of patients after out-of-hospital cardiac arrest (OHCA) and cardiopulmonary resuscitation (CPR). Methods A total of 221 patients with OHCA after successful CPR admitted to Wuxi Emergency Center from January 2021 to November 2023 were selected as the study subjects. Based on their 28-day prognosis,patients who died or achieved respiratory and heartbeat recovery without regaining consciousness were classified into the poor prognosis group,while the remaining patients were categorized into the good prognosis group. Clinical data were collected,including gender,age,body mass index (BMI),underlying diseases (hypertension,diabetes,hyperlipidemia,coronary heart disease),smoking history,alcohol history,cerebrovascular history,CPR duration,OHCA causes (cardiogenic,non-cardiogenic),acute physiology and chronic health evaluationⅡ(APACHEⅡ),sequential organ failure assessment (SOFA),Glasgow coma scale (GCS),respiratory rate (RR),heart rate,mean arterial pressure (MAP),body temperature,white blood cell count (WBC),red blood cell count (RBC),platelet count (PLT),blood lactate (Lac),procalcitonin (PCT),C-reactive protein (CRP),serum alanine aminotransferase (ALT),aspartate aminotransferase (AST),urea nitrogen (BUN),serum creatinine (SCr),fibrinogen (Fib),D-dimer and epinephrine dose,presence or absence of hypothermia therapy,duration of mechanical ventilation,ICU stay time and stress glucose elevation ratio (SHR),PETCO2,etc.,and the differences in clinical data between the two groups were compared. The Logistic regression model was used to analyze the factors affecting the short-term prognosis of OHCA patients after successful CPR,and the receiver operator characteristic curve (ROC curve) was used to evaluate the predictive performance of each influencing factor on the prognosis of patients. Results Finally,221 patients with OHCA after successful CPR were included,40 had a good prognosis and 181 had a poor prognosis. The SHR,APACHEⅡ score,SOFA score,Lac,epinephrine dosage>5 mg ratio,and ICU stay in the poor prognosis group were higher than those in the good prognosis group[SHR:1.19±0.14 vs. 1.02±0.09,APACHEⅡ score:23.01±3.15 vs. 17.01±2.41,SOFA score:8.62±1.09 vs. 6.32±0.98,Lac (mmol/L):10.32±1.69 vs. 7.01±1.02,epinephrine dosage>5 mg ratio:67.96％ (123/181) vs. 45.00％ (18/40),ICU stay time (days):8.59±1.42 vs. 8.01±1.53,all P<0.05],PETCO2 and GCS scores were lower than those in the good prognosis group[PETCO2 (mmHg,1 mmHg≈0.133 kPa):20.04±2.83 vs. 34.92±3.01,GCS score:3.82±0.43 vs. 5.04±0.82,both P<0.05]. Logistic regression analysis showed that APACHEⅡ score,GCS score,SHR,and PETCO2 were all factors affecting the short-term prognosis of OHCA patients after successful CPR[odds ratios (OR) were 6.385,0.421,4.133,and 0.659,respectively,and 95％ confidence interval (95％CI) were 2.627-15.518,0.173-1.023,1.701-10.045,and 0.271-1.602,respectively,P values were all 0.000]. ROC curve analysis showed that SHR,PETCO2 and their combined tests had predictive value for the short-term prognosis of OHCA patients after successful CPR[area under the curve (AUC) and 95％CI were 0.705 (0.591-0.819),0.723 (0.612-0.834),0.886 (0.817-0.954),and the sensitivities were 65.19％,70.17％,and 85.08％,respectively,the specificities were 70.00％,77.50％ and 87.50％,and the P values were 0.012,0.005 and 0.000,respectively]. Conclusion Stress blood glucose elevation and PETCO2 were associated with the prognosis of OHCA patients during prehospital transport after successful CPR,and SHR combined with PETCO2 had good prognostic efficacy in predicting OHCA patients after successful CPR.

Objective To investigate the predictive value of stress glucose elevation and partial pressure of end-expiratory carbon dioxide (PETCO2) on the prognosis of patients after out-of-hospital cardiac arrest (OHCA) and cardiopulmonary resuscitation (CPR). Methods A total of 221 patients with OHCA after successful CPR admitted to Wuxi Emergency Center from January 2021 to November 2023 were selected as the study subjects. Based on their 28-day prognosis,patients who died or achieved respiratory and heartbeat recovery without regaining consciousness were classified into the poor prognosis group,while the remaining patients were categorized into the good prognosis group. Clinical data were collected,including gender,age,body mass index (BMI),underlying diseases (hypertension,diabetes,hyperlipidemia,coronary heart disease),smoking history,alcohol history,cerebrovascular history,CPR duration,OHCA causes (cardiogenic,non-cardiogenic),acute physiology and chronic health evaluationⅡ(APACHEⅡ),sequential organ failure assessment (SOFA),Glasgow coma scale (GCS),respiratory rate (RR),heart rate,mean arterial pressure (MAP),body temperature,white blood cell count (WBC),red blood cell count (RBC),platelet count (PLT),blood lactate (Lac),procalcitonin (PCT),C-reactive protein (CRP),serum alanine aminotransferase (ALT),aspartate aminotransferase (AST),urea nitrogen (BUN),serum creatinine (SCr),fibrinogen (Fib),D-dimer and epinephrine dose,presence or absence of hypothermia therapy,duration of mechanical ventilation,ICU stay time and stress glucose elevation ratio (SHR),PETCO2,etc.,and the differences in clinical data between the two groups were compared. The Logistic regression model was used to analyze the factors affecting the short-term prognosis of OHCA patients after successful CPR,and the receiver operator characteristic curve (ROC curve) was used to evaluate the predictive performance of each influencing factor on the prognosis of patients. Results Finally,221 patients with OHCA after successful CPR were included,40 had a good prognosis and 181 had a poor prognosis. The SHR,APACHEⅡ score,SOFA score,Lac,epinephrine dosage>5 mg ratio,and ICU stay in the poor prognosis group were higher than those in the good prognosis group[SHR:1.19±0.14 vs. 1.02±0.09,APACHEⅡ score:23.01±3.15 vs. 17.01±2.41,SOFA score:8.62±1.09 vs. 6.32±0.98,Lac (mmol/L):10.32±1.69 vs. 7.01±1.02,epinephrine dosage>5 mg ratio:67.96％ (123/181) vs. 45.00％ (18/40),ICU stay time (days):8.59±1.42 vs. 8.01±1.53,all P<0.05],PETCO2 and GCS scores were lower than those in the good prognosis group[PETCO2 (mmHg,1 mmHg≈0.133 kPa):20.04±2.83 vs. 34.92±3.01,GCS score:3.82±0.43 vs. 5.04±0.82,both P<0.05]. Logistic regression analysis showed that APACHEⅡ score,GCS score,SHR,and PETCO2 were all factors affecting the short-term prognosis of OHCA patients after successful CPR[odds ratios (OR) were 6.385,0.421,4.133,and 0.659,respectively,and 95％ confidence interval (95％CI) were 2.627-15.518,0.173-1.023,1.701-10.045,and 0.271-1.602,respectively,P values were all 0.000]. ROC curve analysis showed that SHR,PETCO2 and their combined tests had predictive value for the short-term prognosis of OHCA patients after successful CPR[area under the curve (AUC) and 95％CI were 0.705 (0.591-0.819),0.723 (0.612-0.834),0.886 (0.817-0.954),and the sensitivities were 65.19％,70.17％,and 85.08％,respectively,the specificities were 70.00％,77.50％ and 87.50％,and the P values were 0.012,0.005 and 0.000,respectively]. Conclusion Stress blood glucose elevation and PETCO2 were associated with the prognosis of OHCA patients during prehospital transport after successful CPR,and SHR combined with PETCO2 had good prognostic efficacy in predicting OHCA patients after successful CPR.