Objective As economy in China growing fast, it will in turn bring changes on the status of genitourinary cancer inpatients. Methods A survey has been made of urological inpatients from January 1951 to December 2000 in the Institute of Urology of Peking University to find the changing status of genitourinary cancer in the recent 50 years. Results From January 1951 to December 2000, there were 28 521 urological inpatients. The cancer patient in the first and second 25 years constituted 19.5% and 28.2% respectively. Since 1970s renal cancer and prostate cancer increased dramatically from 10.4% to 28.7% and 3.3% to 13.4% respectively. Conclusions The introduction of new diagnostic techniques, the expansion of the aged population and a high fat diet are considered to be responsible for this change.

ObjectiveTo investigate the role and clinical significance of interferon regulatory factor 7 (IRF7) and Toll-like receptor 9 (TLR9) in the development of condyloma acuminatum (CA).MethodsReverse transcription-PCR was performed to analyze the mRNA expressions of IRF7 and TLR9 in peripheral blood mononuclear cells(PBMCs) of 25 patients with CA and 20 normal human controls.ResultsThe expression levels of IRF7 and TLR9 mRNA in PBMCs were significantly higher in the patients with CA than in the controls(both P ＜ 0.01 ).Conclusion There is a significant increase in the expression of IRF7 and TLR9 in the PBMCs of patients with CA.

Objective To detemine the effect of autografts of in-vitro cultured corneal limbal stem cells for treating pterygium. Methods A total of 11 cases (12 eyes) with pterygium were treated with autograft of in-vitro cultured corneal limbal stem cells and were followed-up for 6-15 months. Results During the follow-up pterygium recurred in 1 eye (8.33 %) . All of the grafts survived well and no immunological rejection or other complication occurred. Conclusion Autograft of in vitro cultured corneal limbal stem cells is an effective and valuable method to treat pterygium.

本文在“国际残疾分类”的基础上，围绕康复诊断名称的标准化，进行了初步探讨，力求使之适合于临床康复的应用及康复病案管理。

Objective To study the effect of intrauterine hyperglycemia on leptin level and offspring development in rats.Methods Female and male adult Wistar rats were mated,streptozotocin (STZ,50 mg/kg) was administered intraperitoneally on 5th day of gestation to induce diabetic model,diabetic pups (DP) were exposed to intrauterine hyperglycemia;control pups(CP) were exposed to controls,which was injected with citrate buffer,8 pups were choosed from each group.Weight gain between 3-10 weeks were recorded.Plasma leptin was detected by enzyme-linked immunosorbent assay (ELISA) when the rats were 11 weeks old,and the expression of leptin receptor in hypothalamus was measured at protein level by histomorphology and mRNA level measured by realtime PCR[expressed with integral absorbance(IA)]in 11weeks in order to discuss the relation of leptin and offspring development.Results The fasting blood glucose level was significantly higher in diabetic mother compared with the controls[(28.3±5.1) mmol/Lvs.(6.3±1.4) mmol/L,P＜0.05].However,there was no difference between the fasting blood glucose level in DP group and CP group[(5.1±0.8) mmol/L vs.(5.3± 0.6) mmol/L,P ＞ 0.05].The growth rate between 3-10 weeks was significantly higher in DP group 649.7% than CP group 479.2%,P ＜0.05.The base insulin level was lower in DP group[(0.76±0.37) μg/L vs.(1.06±0.14)μg/L,P ＜ 0.05];while there was no difference in plasma leptin and the expression of ieptin receptor in hypothalamns[(113±37) μg/L vs.(128±40) μg/L,P ＞0.05].The growth rate was not associated with plasma leptin in DP group (r=-0.501,P=0.311) but associated in CP group (r=-0.553,P=0.001).The protein level of DP group (4125±414) did not significantly differ from that of CP group (4244±511).The median of mRNA of leptin receptor in hypothalamus in DP group did not altered significantly compared with that of CP group(1.25 vs 1.80,P＞0.05).Conclusions Intrauterine hyperglycemia accelerated growth rate of offsprings between 3 and 10 weeks,however,plasma leptin was not discreased,which indicated leptin resistance.Intrauterine hyperglycemia did not influence the expression of leptin receptor in hypopthalamus in offsprings,this suggested the leptin resistance may be not caused by the quantity of leptin receptors.