Migraine is a common neurological disorder，with a significantly higher prevalence rate in women than in men，and more than half of female patients have headache attacks associated with menstruation.Migraine in women is closely associated with the changes in hormones during the menstrual cycle，and the effect of “estrogen withdrawal” might be one of the possible mechanisms.Changes in hormones may play an important role in the development of migraine.Understanding the relationship between changes in each life stage and physiological cycle of women and headache may help to develop individualized treatment strategies，thereby improving the symptoms and prognosis of patients.