Handgrip strength asymmetry has emerged as a significant indicator of impaired muscle function, often associated with recurrent falls, cognitive decline, depression, disability, and accelerated mortality.This phenomenon has garnered clinical attention due to its detrimental effects, leading to a surge in research on handgrip strength asymmetry in recent years.However, there is currently no standardized protocol for measuring handgrip strength asymmetry across studies.Therefore, the purpose of this paper is to critically review the existing literature on handgrip strength asymmetry, with the aim of providing insights for future clinical studies and the development of measurement protocols.