1.Daily steps corresponding to the reference quantity of physical activity of Exercise and Physical Activity Reference for Health Promotion 2006 (EPAR2006) assessed by accelerometer
Yoshitake Oshima ; Yuki Hikihara ; Kazunori Ohkawara ; Kazuko Ishikawa-Takata ; Rieko Miyake ; Naoyuki Ebine ; Izumi Tabata ; Shigeho Tanaka
Japanese Journal of Physical Fitness and Sports Medicine 2012;61(2):193-199
The purpose of this study was to determine daily steps corresponding to the reference value for the quantity of Physical Activity and Exercise for Health Promotion 2006 (23 METs·h/wk) considering non-locomotive activities. Two hundred and thirty one men and 224 women wore a tri-axial accelerometer for two weeks. We analyzed the data in each age group (young (less than 40 years), middle-aged (40 to 59 years), and elderly (60 years or more) groups), also. There were significant relationships between daily steps and locomotive activity (r = 0.762 to 0.820, p < 0.001) and total (locomotive and non-locomotive) physical activity (r = 0.706 to 0.824, p < 0.001) with intensity of 3 METs or more in all groups. The daily steps corresponding to 23 METs·h/wk, calculated using regression lines between the daily steps and total physical activities with intensity of 3 METs or more in men and women were 6,534 steps/d and 6,119 steps/d. On the other hand, the daily steps corresponding to 23 METs·h/wk, calculated using regression lines between the daily steps and locomotive activities with intensity of 3 METs or more in men and women were 7,888 steps/d and 8,584 steps/d. These results suggest that non-locomotive activity should also be taken into consideration in the case of assessment of a daily physical activity.
2.Clinical Characteristics of Esophageal Motility Disorders in Patients With Heartburn
Satsuki TAKAHASHI ; Tomoaki MATSUMURA ; Tatsuya KANEKO ; Mamoru TOKUNAGA ; Hirotaka OURA ; Tsubasa ISHIKAWA ; Ariki NAGASHIMA ; Wataru SHIRATORI ; Naoki AKIZUE ; Yuki OHTA ; Atsuko KIKUCHI ; Mai FUJIE ; Keiko SAITO ; Kenichiro OKIMOTO ; Daisuke MARUOKA ; Tomoo NAKAGAWA ; Makoto ARAI ; Jun KATO ; Naoya KATO
Journal of Neurogastroenterology and Motility 2021;27(4):545-554
Background/Aims:
Esophageal motility disorders (EMDs) contribute to the pathophysiology of gastroesophageal reflux disease. However, the causes of EMDs and their impact on gastroesophageal reflux disease-associated symptoms remain unknown. This study aims to elucidate clinical features associated with various types of EMDs in patients with heartburn symptoms.
Methods:
Of the 511 patients who underwent high-resolution manometry, 394 who were evaluated for heartburn symptoms were examined. Patients subjected to high-resolution manometry were classified into 4 groups: outflow obstruction group, hypermotility group, hypomotility group, and normal motility group. Symptoms were evaluated using 3 questionnaires. Patient characteristics and symptoms for each EMD type were compared with those of the normal motility group.
Results:
Of the 394 patients, 193 (48.9%) were diagnosed with EMDs, including 71 with outflow obstruction, 15 with hypermotility, and 107 with hypomotility. The mean dysphagia score was significantly higher in each of the 3 EMD groups compared with those with normal motility. The mean acid reflux and dyspepsia scores were significantly lower in the outflow obstruction group (P < 0.05). The mean body mass index and median Brinkman index were significantly higher in the hypermotility group (P = 0.001 and P = 0.018, respectively), whereas the mean diarrhea and constipation scores were significantly lower in the hypomotility group (P < 0.05).
Conclusions
The results of our study indicate that different EMDs have distinct characteristics. Cigarette smoking and high body mass index were associated with esophageal hypermotility. Assessment of the dysphagia symptom scores may help identify patients with EMDs.
3.High expression of folate receptor alpha is associated with poor prognosis in patients with cervical cancer
Shu YAZAKI ; Yuki KOJIMA ; Hiroshi YOSHIDA ; Shigemasa TAKAMIZAWA ; Rui KITADAI ; Tadaaki NISHIKAWA ; Tatsunori SHIMOI ; Kazuki SUDO ; Ayumi SAITO ; Hitomi Sumiyoshi OKUMA ; Maki TANIOKA ; Emi NOGUCHI ; Masaya UNO ; Mitsuya ISHIKAWA ; Tomoyasu KATO ; Yasuhiro FUJIWARA ; Yuichiro OHE ; Kan YONEMORI
Journal of Gynecologic Oncology 2022;33(6):e82-
Objective:
Folate receptor α (FRα) is a membrane protein expressed in various solid tumors but has limited expression in normal cells. Therefore, FRα is an attractive target for cancer treatment. This study aimed to investigate the relationship between FRα expression and the clinicopathological characteristics and survivals of cervical cancer.
Methods:
This retrospective study included patients with cervical cancer who underwent primary surgery between 2000 and 2020 at our institution. Immunohistochemical staining of FRα was performed using an anti-folate-binding protein/FBP antibody. FRα-positive staining was defined as ≥5% of tumor staining and FRα-high as ≥50% tumor staining with ≥2+ intensity. The association between FRα expression and survival was assessed using multivariate Cox regression analysis, adjusting for established prognostic factors.
Results:
Overall, 123 patients were identified, and 140 tumor samples, including 17 paired primary and metastatic samples, were evaluated. As histological types, 67 patients had squamous cell carcinoma (SCC), and 56 patients had non-SCC. All primary tumors were FRα-positive. High FRα expression was observed in 25% of the cases and differed according to histology (SCC vs. non-SCC, 14.9% vs. 37.5%, p=0.004). FRα expression was significantly higher in metastatic tumors than in primary (170 [IQR, 140–205] vs. 125 [IQR, 110–150], p=0.0006). High FRα expression was significantly associated with worse overall survival (hazard ratio, 6.73; 95% confidence interval, 2.21–20.53; p=0.001).
Conclusion
In cervical cancer, FRα expression was elevated in metastatic tumors and high expression was associated with a worse prognosis. Our study supports the development of FRα-targeted therapy for advanced cervical cancer.
4.Clinical Characteristics of Esophageal Motility Disorders in Patients With Heartburn
Satsuki TAKAHASHI ; Tomoaki MATSUMURA ; Tatsuya KANEKO ; Mamoru TOKUNAGA ; Hirotaka OURA ; Tsubasa ISHIKAWA ; Ariki NAGASHIMA ; Wataru SHIRATORI ; Naoki AKIZUE ; Yuki OHTA ; Atsuko KIKUCHI ; Mai FUJIE ; Keiko SAITO ; Kenichiro OKIMOTO ; Daisuke MARUOKA ; Tomoo NAKAGAWA ; Makoto ARAI ; Jun KATO ; Naoya KATO
Journal of Neurogastroenterology and Motility 2021;27(4):545-554
Background/Aims:
Esophageal motility disorders (EMDs) contribute to the pathophysiology of gastroesophageal reflux disease. However, the causes of EMDs and their impact on gastroesophageal reflux disease-associated symptoms remain unknown. This study aims to elucidate clinical features associated with various types of EMDs in patients with heartburn symptoms.
Methods:
Of the 511 patients who underwent high-resolution manometry, 394 who were evaluated for heartburn symptoms were examined. Patients subjected to high-resolution manometry were classified into 4 groups: outflow obstruction group, hypermotility group, hypomotility group, and normal motility group. Symptoms were evaluated using 3 questionnaires. Patient characteristics and symptoms for each EMD type were compared with those of the normal motility group.
Results:
Of the 394 patients, 193 (48.9%) were diagnosed with EMDs, including 71 with outflow obstruction, 15 with hypermotility, and 107 with hypomotility. The mean dysphagia score was significantly higher in each of the 3 EMD groups compared with those with normal motility. The mean acid reflux and dyspepsia scores were significantly lower in the outflow obstruction group (P < 0.05). The mean body mass index and median Brinkman index were significantly higher in the hypermotility group (P = 0.001 and P = 0.018, respectively), whereas the mean diarrhea and constipation scores were significantly lower in the hypomotility group (P < 0.05).
Conclusions
The results of our study indicate that different EMDs have distinct characteristics. Cigarette smoking and high body mass index were associated with esophageal hypermotility. Assessment of the dysphagia symptom scores may help identify patients with EMDs.
5.Impact of Early Mobilization on Ambulation Recovery in Elderly and/or Patients with Severe Subarachnoid Hemorrhage: A Multicenter Retrospective Study
Shota SUZUKI ; Hikaru TAKARA ; Shuhei SATOH ; Yoko ABE ; Shohei MIYAZATO ; Mayu HAMADA ; Yuki ISHIKAWA ; Shin MINAKATA ; Masamichi MORIYA ; Shigeru OBAYASHI
The Japanese Journal of Rehabilitation Medicine 2025;():23065-
Objective: To clarify whether early mobilization is a predictive factor for ambulation recovery in elderly patients and/or patients with severe subarachnoid hemorrhage (SAH).Methods: This multicenter retrospective observational study included 471 patients with treated SAH (Group 1). We focused on SAH patients with a poor prognosis, including a subgroup of elderly SAH patients (age>65 years:n=203) (Group 2) and patients with severe SAH (World Federation of Neurological Societies [WFNS] grade IV or V:n=117) (Group 3). The chi-square test and Mann-Whitney U test were used to compare the differences between the ambulation recovery group and the non-recovery group. Multivariable logistic regression analysis modeling was used to estimate odds ratios and 95% confidence intervals of early mobilization for the ambulation-recovered group within 30 days of onset compared with the unrecovered group. Other covariates examined as possible confounders of the outcome were age, sex, location of the ruptured aneurysm, modified Fisher scale score, WFNS grade, mode of treatment (surgical vs. endovascular), duration of cerebrospinal fluid drainage, days on mechanical ventilation, intracerebral hemorrhage, symptomatic cerebral vasospasm, complications, shunt placement for hydrocephalus, and time to start mobilization.Results: Early mobilization was an independent predictive factor for gait recovery in all groups. Furthermore, location of the ruptured aneurysm (anterior circulation), absence of complications, and absence of shunt placement were independent factors for ambulation recovery in all groups.Conclusion: Early mobilization in elder or/and sever patients with SAH may be a predictive factor for ambulation recovery within 30 days of onset.
6.Impact of Early Mobilization on Ambulation Recovery in Elderly and/or Patients with Severe Subarachnoid Hemorrhage:A Multicenter Retrospective Study
Shota SUZUKI ; Hikaru TAKARA ; Shuhei SATOH ; Yoko ABE ; Shohei MIYAZATO ; Mayu HAMADA ; Yuki ISHIKAWA ; Shin MINAKATA ; Masamichi MORIYA ; Shigeru OBAYASHI
The Japanese Journal of Rehabilitation Medicine 2025;62(2):189-200
Objective: To clarify whether early mobilization is a predictive factor for ambulation recovery in elderly patients and/or patients with severe subarachnoid hemorrhage (SAH).Methods: This multicenter retrospective observational study included 471 patients with treated SAH (Group 1). We focused on SAH patients with a poor prognosis, including a subgroup of elderly SAH patients (age>65 years: n=203) (Group 2) and patients with severe SAH (World Federation of Neurological Societies [WFNS] grade IV or V: n=117) (Group 3). The chi-square test and Mann-Whitney U test were used to compare the differences between the ambulation recovery group and the non-recovery group. Multivariable logistic regression analysis modeling was used to estimate odds ratios and 95% confidence intervals of early mobilization for the ambulation-recovered group within 30 days of onset compared with the unrecovered group. Other covariates examined as possible confounders of the outcome were age, sex, location of the ruptured aneurysm, modified Fisher scale score, WFNS grade, mode of treatment (surgical vs. endovascular), duration of cerebrospinal fluid drainage, days on mechanical ventilation, intracerebral hemorrhage, symptomatic cerebral vasospasm, complications, shunt placement for hydrocephalus, and time to start mobilization.Results: Early mobilization was an independent predictive factor for gait recovery in all groups. Furthermore, location of the ruptured aneurysm (anterior circulation), absence of complications, and absence of shunt placement were independent factors for ambulation recovery in all groups.Conclusion: Early mobilization in elder or/and sever patients with SAH may be a predictive factor for ambulation recovery within 30 days of onset.
7.Effect of a combination of astaxanthin supplementation, heat stress, and intermittent reloading on satellite cells during disuse muscle atrophy.
Toshinori YOSHIHARA ; Takao SUGIURA ; Nobuyuki MIYAJI ; Yuki YAMAMOTO ; Tsubasa SHIBAGUCHI ; Ryo KAKIGI ; Hisashi NAITO ; Katsumasa GOTO ; Daijiro OHMORI ; Toshitada YOSHIOKA
Journal of Zhejiang University. Science. B 2018;19(11):844-852
We examined the effect of a combination of astaxanthin (AX) supplementation, repeated heat stress, and intermittent reloading (IR) on satellite cells in unloaded rat soleus muscles. Forty-nine male Wistar rats (8-week-old) were divided into control, hind-limb unweighting (HU), IR during HU, IR with AX supplementation, IR with repeated heat stress (41.0-41.5 °C for 30 min), and IR with AX supplementation and repeated heat stress groups. After the experimental period, the antigravitational soleus muscle was analyzed using an immunohistochemical technique. Our results revealed that the combination of dietary AX supplementation and heat stress resulted in protection against disuse muscle atrophy in the soleus muscle. This protective effect may be partially due to a higher satellite cell number in the atrophied soleus muscle in the IR/AX/heat stress group compared with the numbers found in the other groups. We concluded that the combination treatment with dietary AX supplementation and repeated heat stress attenuates soleus muscle atrophy, in part by increasing the number of satellite cells.
Animals
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Body Weight
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Dietary Supplements
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Fibrinolytic Agents/pharmacology*
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Heat-Shock Response
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Hindlimb
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Hot Temperature
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Immunohistochemistry
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Male
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Muscle, Skeletal
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Muscular Atrophy/drug therapy*
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Oxidative Stress
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Rats
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Rats, Wistar
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Satellite Cells, Skeletal Muscle/cytology*
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Xanthophylls/pharmacology*
8.Evaluation of Community Health Medical Education:The Elderly Home Visit Program
Masayo KOJIMA ; Daisaku ASAI ; Daiki ISHIKAWA ; Yuki KIMURA ; Keiko AKASHI ; Hiroyasu AKATSU ; Hirotaka OHARA ; Yoshihiro KAWADE ; Kazunori KIMURA ; Masumi SUZUI ; Tadashi SUZUKI ; Tadahiro HASHITA ; Jyunichiro HAYANO ; Satona MURAKAMI ; Miyuki YAMAMOTO ; Kiyofumi ASAI
Medical Education 2019;48(4):221-235
Introduction: Research was carried out using a mixed method approach in order to evaluate the educational effects of medical students' visit of an elderly home.Methods: Focus group interviews were conducted with 5 medical students and 5 elderlies. All interviewees had experienced the visitation program more than three times. Self-administrative questionnaires were built based on the results of the focus group interview. The questionnaire was then distributed to medical students and elderlies who participated in the program.Results: A total of 84 medical students and 30 elderlies provided informed consent to participate in the study and returned the questionnaire. Nearly 70 percent of the students answered that they had gotten to know about the life of elderly people and sixty percent of the elderlies answered they had experienced some favorable changes after joining the program. While ninety percent of the elderly were satisfied with the program, only half of the students showed positive comments toward it.Discussion: To help all students participate in this program more actively, more organized planning is necessary so that students can have more chances to build communication skills and clarify their own objectives when visiting the elderly.