This study aimed to examine the relationship between daily outdoor playing time assessed using questionnaires for parents and daily moderate-to-vigorous physical activity (MVPA) using triaxial accelerometers for young children (213 boys: 5.8±0.6years and 193 girls: 5.9±0.6years). The study also examined the potential relationships between daily MVPA and exercise habits or familial and preschool factors which were assessed using questionnaires for parents. Daily MVPA was assessed using a triaxial accelerometer (ActivTracer, GMS) for 6 consecutive days, including weekdays and weekends. Outdoor playing time and percentage of outdoor playing time more than 60 min/day were 81±62 min/day and 64% for boys and 78±61 min/day and 62% for girls, respectively. Outdoor playing time was not significantly correlated with MVPA. The study found that no factors for MVPA, including exercise habits, were correlated with MVPA when adjusted for age, body height and log-body weight, except that MVPA for girls in kindergartens was higher than that in nursery schools. These findings suggest that the percentage of outdoor playing time more than 60 min/day was about 2/3 in young children. The questionnaire didn't reflect their MVPA. The factors used in the present study except for the preschool type for girls may not contribute to the time spent in MVPA in preschool children.

This study sought to examine the potential relationships of physical education (PE) participation at preschool and sports club (SC) participation out of school and daily physical activity (PA) measured objectively using a triaxial accelerometer, with physical fitness in preschool children. Physical fitness testing was used to measure both health-related and skill-related parameters of fitness in 191 Japanese preschoolers in the Kanto region (94 boys and 97 girls, 5.6 ± 0.6 years). Daily PA was assessed using a triaxial accelerometer (ActivTracer, GMS) for 6 consecutive days, including weekdays and weekend days. PE and SC participation was assessed using questionnaires for preschool teachers or parents of subjects, respectively. All health-related and skill-related physical fitness and total Z-score were correlated with time spent with physical activity ratio (PAR)≧4 when adjusted for age, sex, body height and weight. In addition, greater grip strength was associated with PE participation at preschool, and 25 m run speed was associated with SC participation, also. However, 25 m run speed was negatively associated with PE participation. These findings suggest that daily PA may contribute to the development of both health-related and skill-related fitness in preschool children, although further research on the cause-effect relationship is needed. Moreover, participation in a SC may contribute to the development of running speed.

Gastric adenocarcinoma of the fundic gland mucosa type (GA-FGM) was proposed as a new variant of gastric adenocarcinoma of the fundic gland type (GA-FG). However, at present, the influence of Helicobacter pylori and the speed of progression and degree of malignancy in GA-FGM remain unclear. Herein, we report the first case of intramucosal GA-FGM that was endoscopically observed before and after H. pylori eradication over 15 years. The lesion showed the same tumor size with no submucosal invasion and a low MIB-1 labeling index 15 years after its detection using endoscopy. The endoscopic morphology changed from 0-IIa before H. pylori eradication to 0-IIa+IIc and then 0-I after H. pylori eradication. These findings suggest that the unaltered tumor size reflects low-grade malignancy and slow growth, and that the endoscopic morphology is influenced by H. pylori eradication.

Objectives: Diagnosis and treatment of osteoporosis are instrumental in obtaining good outcomes of hip surgery.Measuring bone mineral density (BMD) using dual-energy X-ray absorptiometry (DXA) is the gold standard for diagnosing osteoporosis. However, due to limited access to DXA, there is a need for a screening tool to identify patients at a higher risk of osteoporosis. We analyzed the potential utility of the Osteoporosis Self-assessment Tool for Asians (OSTA) as a screening tool for osteoporosis. Methods: A total of 1378 female patients who underwent hip surgery at 8 institutions were analyzed. For each patient, the BMD of the proximal femoral region was measured by DXA (DXA-BMD), and the correlation with OSTA score (as a continuous variable) was assessed. Receiver operating characteristic (ROC) curve analysis was performed to assess the ability of OSTA score to predict osteoporosis. Lastly, the OSTA score was truncated to yield an integer (OSTA index) to clarify the percentage of patients with osteoporosis for each index. Results: DXA-BMD showed a strong correlation with OSTA (r = 0.683; P < 0.001). On ROC curve analysis, the optimal OSTA score cut-off value of − 5.4 was associated with 73.8% sensitivity and 80.9% specificity for diagnosis of osteoporosis (area under the curve: 0.842). A decrease in the OSTA index by 1 unit was associated with a 7.3% increase in the probability of osteoporosis. Conclusions OSTA is a potentially useful tool for screening osteoporosis in patients undergoing hip surgery. Our findings may help identify high-risk patients who require further investigation using DXA.

The primary aim of this study was to examine moderate-to-vigorous physical activity (MVPA) levels in preschool children during indoor and outdoor free playing time and during preschool physical education (PE) classes. The secondary aim was to determine which types of PE lessons are the best for increasing the percentage of MVPA. Physical activity during free playing time and in lessons was objectively evaluated with a triaxial accelerometer in preschool boys and girls (n = 281). Minutes of physical activity were categorized into physical activity ratios (PAR). MVPA was defined as PAR ≥3.0. Time tables and PE lesson types were recorded using logs kept by class teachers. The percentage of MVPA in outdoor free playing time (38.9±16.3%) was significantly higher than that of indoor free playing time (12.6±10.1%, p<0.001). On the other hand, there was no significant difference between the percentage in MVPA in outdoor free playing time and the percentage in PE lessons (n=94: 38.0±19.4%vs. 34.9±15.8%, ns). After adjustment for gender, age, body height and weight and preschool, there were not significantly different the percentage of MVPA among contents of PE lessons. In conclusion, children engaged in almost 30~40% MVPA during outdoor free playing time or PE. The children also engaged MVPA during indoor free playing time.

Objective: DNA methyltransferase 1 (DNMT1) is crucial to maintaining methylation during DNA replication and DNA repair. DNMT1 mutations have been identified in two neurological syndromes, including hereditary sensory and autonomic neuropathy type IE (HSAN IE) with dementia and hearing loss and autosomal dominant cerebellar ataxia, deafness and narcolepsy. It is likely that DNMT1 mutations lead to various symptoms of the central and peripheral nervous system. The aim of this study was to examine the clinical characteristics, especially the initial symptoms, in the cases of DNMT1 mutations. Methods: We investigated the clinical manifestation and examination findings of four cases of HSAN IE from one family with the DNMT1 mutation c.1531Y>C (p.Try511His). Results: All four cases exhibited sensory neuropathy, cerebellar ataxia, and hearing loss, all of which were demonstrated by the audiograms. The initial symptoms of the four cases included hearing loss (n=1), gait disturbance (n=1), and depressive mood (n=2). Depressive symptoms are reported in some cases with HSAN IE, however, there are currently no published reports that describe them as primary symptoms. The CSF orexin level was measured in three cases, revealing normal values in two cases and intermediate values in one case, in which the patient exhibited rapid eye movement (REM) sleep behavior disorder. Conclusion: Our findings suggest that in cases with HSAN IE or the DNMT1 mutation, psychiatric symptoms should be taken into account as one of the initial manifestations of the disease.