Purpose: This study evaluated the effect of the a good sleep program on sleep quality, stress, and functional health in old-old women, that is women over the age of 75 years, who had insomnia. Methods: This quasi-experimental study used a non-equivalent control group pretest-posttest design. The participants were 35 old-old women with insomnia: 18 in the experimental group and 17 in the control group. Data were collected from August 24 and October 12, 2020. The experimental group, participated in a six-session good sleep program consisting of multiple components, including sleep health education, aromatherapy (lavender scent inhalation), abdominal breathing, sleep hygiene, and walking exercises was conducted. The Good Sleep Program was developed based on Cox’s interaction model of client health behavior. The control group received only a booklet on good sleep. The scales used for pre and post-intervention measurements were the Pittsburgh Sleep Quality Index, Perceived Stress Scale, and Functional Health Pattern Assessment Screening Tool. Results: Compared to the control group, the experimental group exhibited significant improvements in the quality of sleep (t=-3.92, p<.001), perceived stress (t=-3.35, p=.002), and functional health (t=2.97, p=.005). Conclusion The Good Sleep Program can be used to reduce stress and improve sleep and overall health in old-old women.

Purpose: This study evaluated the effect of the a good sleep program on sleep quality, stress, and functional health in old-old women, that is women over the age of 75 years, who had insomnia. Methods: This quasi-experimental study used a non-equivalent control group pretest-posttest design. The participants were 35 old-old women with insomnia: 18 in the experimental group and 17 in the control group. Data were collected from August 24 and October 12, 2020. The experimental group, participated in a six-session good sleep program consisting of multiple components, including sleep health education, aromatherapy (lavender scent inhalation), abdominal breathing, sleep hygiene, and walking exercises was conducted. The Good Sleep Program was developed based on Cox’s interaction model of client health behavior. The control group received only a booklet on good sleep. The scales used for pre and post-intervention measurements were the Pittsburgh Sleep Quality Index, Perceived Stress Scale, and Functional Health Pattern Assessment Screening Tool. Results: Compared to the control group, the experimental group exhibited significant improvements in the quality of sleep (t=-3.92, p<.001), perceived stress (t=-3.35, p=.002), and functional health (t=2.97, p=.005). Conclusion The Good Sleep Program can be used to reduce stress and improve sleep and overall health in old-old women.

Purpose: This study evaluated the effect of the a good sleep program on sleep quality, stress, and functional health in old-old women, that is women over the age of 75 years, who had insomnia. Methods: This quasi-experimental study used a non-equivalent control group pretest-posttest design. The participants were 35 old-old women with insomnia: 18 in the experimental group and 17 in the control group. Data were collected from August 24 and October 12, 2020. The experimental group, participated in a six-session good sleep program consisting of multiple components, including sleep health education, aromatherapy (lavender scent inhalation), abdominal breathing, sleep hygiene, and walking exercises was conducted. The Good Sleep Program was developed based on Cox’s interaction model of client health behavior. The control group received only a booklet on good sleep. The scales used for pre and post-intervention measurements were the Pittsburgh Sleep Quality Index, Perceived Stress Scale, and Functional Health Pattern Assessment Screening Tool. Results: Compared to the control group, the experimental group exhibited significant improvements in the quality of sleep (t=-3.92, p<.001), perceived stress (t=-3.35, p=.002), and functional health (t=2.97, p=.005). Conclusion The Good Sleep Program can be used to reduce stress and improve sleep and overall health in old-old women.

Cadmium (Cd) exposure primarily occurs through inhalation, either by smoking or occupational exposure to contaminated air. Upon inhalation, Cd ultimately reaches the prostate through the bloodstream. In this review, we investigate the carcinogenic potential of Cd in both respiratory organs and the prostate. Specifically, this review examines cellular metabolism, comprehensive toxicity, and carcinogenic mechanisms by exploring gene ontology, biological networks, and adverse outcome pathways. In the respiratory organs, Cd induces lung cancer by altering the expression of IL1B and FGF2, causing DNA damage, reducing cell junction integrity, and promoting apoptosis. In the prostate, Cd induces prostate cancer by modifying the expression of EDN1 and HMOX1, leading to abnormal protein activities and maturation, suppressing tumor suppressors, and inducing apoptosis. Collectively, this review provides a comprehensive understanding of the carcinogenic mechanisms of Cd in two different organs by adopting toxicogenomic approaches. These insights can serve as a foundation for further research on cadmium-induced cancer, contributing to the establishment of future cancer prevention strategies.

Parkinson’s disease (PD) which has various pathological mechanisms, recently, it is attracting attention to the mechanism via microbiome-gut-brain axis. 6-Shogaol, a representative compound of ginger, have been known for improving PD phenotypes by reducing neuroinflammatory responses. In the present study, we investigated whether 6-shogaol and ginger attenuate degeneration induced by Proteus Mirabilis(P. mirabilis) on the intestine and brain, simultaneously. C57BL/6J mice received P. mirabilis for 5 days. Ginger (300 mg/kg) and 6-shogaol (10 mg/kg) were treated by gavage feeding for 22 days including the period of P. mirabilis treatment. Results showed that 6-shogaol and ginger improved motor dysfunction and dopaminergic neuronal death induced by P. mirabilis treatment. In addition, they suppressed P. mirabilis-induced intestinal barrier disruption, pro-inflammatory signals such as toll-like receptor and TNF-α, and intestinal α-synuclein aggregation. Moreover, ginger and 6-shogaol significantly inhibited neuroinflammation and α-synuclein in the brain. Taken together, 6-shogaol and ginger have the potential to ameliorate PD-like motor behavior and degeneration of dopaminergic neurons induced by P. mirabilis in mice. Here, these findings are meaningful in that they provide the first experimental evidence that 6-shogaol might attenuate PD via regulating gut-brain axis.

Objective:To analyze the failure patterns and survival after stereotactic body radiotherapy (SBRT) in patients with T 1-2N 0M 0 non-small cell lung carcinoma (NSCLC). Methods:Clinical data of early-stage NSCLC patients who received SBRT at Zhejiang Cancer Hospital from January 2012 to September 2018 were retrospectively analyzed. The primary observed endpoint was the pattern of disease progression, which was divided into intra-field recurrence, regional lymph node recurrence and distant metastasis. Overall survival (OS) and progression-free survival (PFS) were calculated by Kaplan-Meier method. Univariate analysis was conducted by log-rank test, and multivariate analysis was performed by Cox's model.Results:A total of 147 patients with 156 lesions were included. The median follow-up time was 44.0 months (16.5-95.5 months). A total of 57 patients (38.8%) progressed: 14 patients (24.5%) had recurrence with the 1-, 3-, and 5-year local recurrence rates of 2.0%, 10.9%, and 14.3%, respectively; 36 patients (63.2%) had Distant metastasis with the 1-, 3- and 5-year distant metastasis rates of 12.2%, 22.4% and 28.6%, respectively; and 7 patients (12.3%) had recurrence complicated with distant metastasis. The 3-, 5- and 7-year OS rates were 80.5%, 64.2% and 49.9% for all patients, respectively. The median OS was 78.4 months. The 3-, 5- and 7-year PFS rates were 64.8%,49.5% and 41.5%, with a median PFS of 57.9 months (95% CI: 42.3-73.5 months). Univariate and multivariate analyses showed that biologically equivalent dose and age were the factors affecting the efficacy of SBRT (both P<0.05). Conclusion:Distant metastasis is the main failure pattern in patients with T 1-2N 0M 0 NSCLC after SBRT. High-risk population should be selected for further systematic treatment to improve the efficacy.

Sudden death during or after percutaneous coronary intervention (PCI) could be led to potential medicolegal disputes. This study aimed to investigate the clinical and postmortem findings in PCI-related deaths-focusing on the current statusto inform preventive strategies against these fatalities. Forty-three cases were retrieved from the National Forensic Service's postmortem records between 2015 and 2021, and the corresponding postmortem findings and clinical information were analyzed. The analyses revealed a relatively consistent annual incidence of PCI-related deaths. Immediate deaths during or shortly after PCI occurred in 17 cases (39.5%), and delayed PCI-related deaths after discharge from the hospital occurred in 26 cases (60.5%). The causes of PCI-related deaths in the postmortem cases were categorized into four groups: PCI complications (11 cases, 26%), acute myocardial infarction (23 cases, 53%), ischemic heart disease (8 cases, 19%), and others (1 case, 2%). Postmortem examinations played a critical role in determining the cause of death and obtaining medical evidence, including pathological findings of the heart as well as those of coronary artery and stent insertion. Our findings suggest that a detailed examination of the heart, coronary arteries, stent status, and atherosclerosis in PCI-related deaths could help provide more accurate information as medical evidence and prevent/resolve potential medicolegal issues. Further, this could advance our understanding of PCI-related deaths and inform future preventive strategies.

As a principal component of solar radiation, ultraviolet B (UVB) exposure can be harmful depending on the duration and intensity because the human body can easily be exposed to it. Many studies have demonstrated that UVB causes a series of inflammatory and other skin disorders. UVB has been classified as the Group 1 carcinogen by the International Agency for Research on Cancer. Diverse studies have focused on UVB exposure but the complex perspective of acute and chronic UVB exposure is still lacking. This review presents the differences between acute and chronic exposure to UVB and summarizes public information in terms of toxicogenomic characteristics. We also demonstrated the differences between adverse effects of acute and chronic UVB exposure on the skin system. From the published literatures, we compared the biological pathways predict of the adverse effects caused by each UVB exposure type. Furthermore, our review not only clarifies the differences in each UVB exposure network but also suggests major hub genes related to cellular mechanisms and diseases that are thought to be affected by acute and chronic UVB exposure.