Objective To explore the effects of dyclonine hydrochloride mucilage and tetracaine hydrochloride jelly on improving the comfort degree in prostatic hyperplasia patients with catheterization. Methods A total of 52 prostatic hyperplasia inpatients with catheterization of urinary surgery at the People's Hospital of Wuzhou, the Guangxi Zhuang Autonomous Region, from January 2015 to March 2017 were selected as the object. All of the patients were divided into two groups by envelope method, 26 cases in each group. Patients in observation group accepted the following treatments involved that an 8-10F improved double channel Foley catheter was covered with little dyclonine mucilage for lubrication firstly; the catheter was inserted as well as the dyclonine mucilage was injected in 1.5 ml; the dyclonine mucilage was injected in 5 ml when the catheter reached the membranous part of posterior urethra and the catheter was drawn; the glans was held with fingers;the front end (15 cm) of draft 16F catheter was covered with the left dyclonine mucilage; the 16F catheter covered with the left dyclonine mucilage was indwelt with routine urethral catheterization 4 minutes after injecting dyclonine mucilage. Patients in control group accepted the 16F catheter with routine urethral catheterization after injecting tetracaine jelly to urethra in 5 ml. The degree of pain, onset time and total duration time of clonic pain, paroxysmal incontinentia urinae, sense of obstruction during indwelling catheter and indwelling time were compared in two groups. Results There was no significant difference in degree of intubation obstruction and intubation time between the two groups (P>0.05). The pain level in the observation group was lower than that in the control group (P< 0.05). There was no significant difference in spasticity pain duration and spasticity pain onset time between the two groups (P> 0.05). The incidence rate of paroxysmal incontinentia urinae in the observation group was less than that in the control group (P<0.05). Conclusions There was no obvious sense of obstruction during indwelling catheter and with light degree of conscious pain in dyclonine group. The dyclonine mucilage can smooth the indwelling catheter by assist catheterization, relieve the pain of patients, improve the degree of comfort and has advantages in preventing and curing the pain of clonic pain of urethra and bladder after indwelling catheter.

OBJECTIVE To investigate the improvement effect and mechanism of desloratadine citrate disodium in mice with hypersensitivity pneumonitis （HP）. METHODS Sixty mice were randomly divided into blank control group （normal saline）， model group （normal saline）， prednisone group （positive control， 20 mg/kg） and desloratadine citrate disodium low-， medium- and high-dose groups （0.5， 1， 2 mg/kg）， with 10 mice in each group. Except for the blank control group， mice in other groups were intraperitoneally injected with ovalbumin （OVA） and exposed to OVA inhalation to establish the HP model. On day 22 post- modeling， mice in each group were administered the corresponding drugs or normal saline， once a day， for 11 consecutive days. After the last administration， lung function and airway hyperreactivity were assessed. The levels of interleukin-1β （IL-1β）， IL-4 and IL-6 in serum as well as the levels of IL-8， IL-13 and IL-17A in bronchoalveolar lavage fluid were determined. Pathological changes in lung tissue of mice were evaluated using Masson staining. Furthermore， the expressions of fibrosis-related proteins， including transforming growth factor β1 （TGF-β1）， type Ⅲ collagen （Col-Ⅲ） and fibronectin （FN） were determined in lung tissues. RESULTS Compared with the blank control group， the model group showed significant deterioration in lung function （P＜ 0.01）， while airway resistance and serum levels of IL-1β， IL-4， IL-6 and the levels of IL-8， IL-13 and IL-17A in the bronchoalveolar lavage fluid were increased significantly （P＜0.01）. The lung tissues exhibited alveolar collapse， atrophy， and structural disarray， along with the formation of extensive deposits of blue collagen fibers， the percentage of positive staining increased significantly （P＜0.01）. Additionally， the expression levels of TGF-β1， Col-Ⅲ， and FN proteins in the lung tissues were also increased significantly （P＜0.01）. After intervention with desloratadine citrate disodium， the pathological changes in the lung tissues of mice in each dosage group of desloratadine citrate disodium showed varying degrees of improvement， and most of the aforementioned indicator levels were significantly reversed （P＜0.05 or P＜0.01）. CONCLUSIONS Desloratadine citrate disodium can improve the lung function and airway hyperreactivity of HP mice， inhibit the release of inflammatory factors in serum and bronchoalveolar lavage fluid， and reduce the deposition of collagen fibers. Its mechanism of action may be related to anti-inflammatory， immunomodulatory， and antifibrotic effects.