Objective　To enhance the correctness in the diagnosis of diffuse neurogliomatosis.　Methods　Patients with diffuse neurogliomatosis were analyzed in terms of manifestations, signs, and MI images. Craniotomy was performed in 2 patients and stereotaxic biopsy in 2. The diagnosis was verified pathologically.　Results　Increased intracraniopressure was noted in all patients. Two brain lobes were involved in 1 patient, and 3 in others. MRI showed low or equal signal areas in T1W1, and high ones in T2W1. Brain edema was note without necrosis, cyst, and bleeding. MRI occupying effect was not significant, corpus callosum enlarged, and no enhancement demonstrated.　Conclusions　Diffuse neurogliomatosis has specific features on MRI. Craniotomy or stereotaxic biopsy was the best choice for diagnosis. Chemotherapy and radiotherapy should be used.

Objective　To enhance the correctness in the diagnosis of diffuse neurogliomatosis.　Methods　Patients with diffuse neurogliomatosis were analyzed in terms of manifestations, signs, and MI images. Craniotomy was performed in 2 patients and stereotaxic biopsy in 2. The diagnosis was verified pathologically.　Results　Increased intracraniopressure was noted in all patients. Two brain lobes were involved in 1 patient, and 3 in others. MRI showed low or equal signal areas in T1W1, and high ones in T2W1. Brain edema was note without necrosis, cyst, and bleeding. MRI occupying effect was not significant, corpus callosum enlarged, and no enhancement demonstrated.　Conclusions　Diffuse neurogliomatosis has specific features on MRI. Craniotomy or stereotaxic biopsy was the best choice for diagnosis. Chemotherapy and radiotherapy should be used.

OBJECTIVETo summarize the experience of minimally invasive treatment in 520 patients with intracranial aneurysms on a retrospective study.

METHODSThe measures used in the treatment of 520 patients were reviewed in terms of timing of surgery, induced-hypotensive anesthesia, brain protection combined with temporal occlusion of the feeding artery, external drainage of CSF, dynamic monitoring of intracranial pressure, blood flow velocity, serum osmolality and CT scanning, anti-vasospasm therapy as well as selected interventional endovascular embolization of aneurysms.

RESULTSOf the 520 patients, 485 were treated with either direct clipping or endovascular embolization and 35 patients were treated non-surgically. In 449 patients undergoing direct clipping and 36 undergoing endovascular embolization, intraoperative rupture of aneurysm occurred in 27 (6.0%) and 0%, respectively. Death occurred in 13 (2.6%), hemiplegia in 8 (1.6%), and vegetative state in 2 (0.4%). The operative mortality of direct clipping was 3.8% in 210 patients before 1990 and 1.8% in 275 patients after 1990 (36 patients undergoing endovascular embolization, the operative mortality was 0%).

CONCLUSIONThe outcome of patients with intacranial aneurysms can be markedly improved and the operative mortality can be lowered by minimally invasive treatment.

Adult ; Aneurysm, Ruptured ; mortality ; therapy ; Embolization, Therapeutic ; Female ; Follow-Up Studies ; Humans ; Intracranial Aneurysm ; mortality ; surgery ; Intraoperative Complications ; mortality ; Male ; Microsurgery ; Middle Aged ; Minimally Invasive Surgical Procedures ; Retrospective Studies ; Survival Rate ; Treatment Outcome