Background/Aims: Gastric acid secretion is suspected to be a pivotal contributor to the pathogenesis of functional dyspepsia. The present study investigates the potential association of the gastric acid secretion estimated by measuring serum pepsinogen with therapeutic responsiveness to the prokinetic drug acotiamide. Methods: Dyspeptic patients consulting participating clinics from October 2017 to March 2019 were prospectively enrolled in the study. The dyspeptic symptoms were classified into postprandial distress syndrome (PDS) and epigastric pain syndrome (EPS). Gastric acid secretion levels were estimated by the Helicobacter pylori infection status and serum pepsinogen using established criteria and classified into hypo-, normo-, and hyper-secretion. Each patient was then administered 100 mg acotiamide thrice daily for 4 weeks, and the response rate to the treatment was evaluated using the overall treatment efficacy scale. Results: Of the 86 enrolled patients, 56 (65.1%) and 26 (30.2%) were classified into PDS and EPS, respectively. The estimated gastric acid secretion was not significantly different between PDS and EPS. The response rates were 66.0% for PDS and 73.1% for EPS, showing no significant difference. While the response rates were stable, ranging from 61.0% to 75.0% regardless of the estimated gastric acid secretion level among subjects with PDF, the rates were significantly lower in hyper-secretors than in non-hyper-secretors among subjects with EPS (42.0% vs 83.0%, P = 0.046). Conclusion Although acotiamide is effective for treating EPS as well as PDS overall, the efficacy is somewhat limited in EPS with gastric acid hypersecretion, with gastric acid suppressants, such as proton pump inhibitors, being more suitable.

Here we report the case of a female patient in her 70s with right hemiplegic stroke and severe sensory impairment whose walking ability was improved by visual and auditory feedback provided by a Gait Exercise Assist Robot (GEAR)．The patient was diagnosed with a left thalamic hemorrhage. Upon being admitted to the convalescent rehabilitation ward, she reported feeling no sensations in her right upper or lower limbs according to the Stroke Impairment Assessment Set (SIAS；both superficial and positional sensations)．Additionally, she had a Berg Balance Scale (BBS) score of 16 and Functional Ambulation Categories (FAC) score of 0. The patient underwent the GEAR intervention for approximately 40 min daily. She was provided visual feedback, in which images of her feet and the sagittal plane were presented on the monitor in front of her；and auditory feedback, in which her paralyzed lower limbs were loaded. No significant improvement was noted in her superficial or positional senses based on the SIAS score at 2 months post-intervention；however, the BBS and FAC scores improved to 46 and 3 points, respectively. These findings suggest that, although it is difficult to improve sensory impairment, repetitive gait training via GEAR-provided visual and auditory feedback and assistive function may improve the gait and walking ability of stroke patients with severe sensory impairment.